DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and Lrrtm2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_821072.1	Gene:	Lrrtm2 / 107065	MGIID:	2389174	Length:	515	Species:	Mus musculus

Alignment Length:	507	Identity:	112/507 - (22%)
Similarity:	183/507 - (36%)	Gaps:	143/507 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQ-- 134
            |..|...||..|.|:    |....|.:.....:|...|.|:..|.|..|.|..:..|.||:..
Mouse    27 LPALGMACPPKCRCE----KLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITALERDQFASFSQL 87

  Fly   135 --------------------LLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLA 179
                                |..|:::.|:...:..:....|.:||||..||||.|.||::....
Mouse    88 TWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPEL 152

  Fly   180 LYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNR 244
            .|.:.:|:.|.|..|.:..:|...|.....|..|:||..||..:|...|||| ..|..|.|:.|:
Mouse   153 FYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGL-IKLRELHLEHNQ 216

  Fly   245 LSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAW--- 306
            |:::.......|:|||.|.|   .||...:|                  ||       |..|
Mouse   217 LTKINFAHFLRLSSLHTLFL---QWNKISNL------------------TC-------GMDWTWS 253

  Fly   307 --DKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRL------IAN--- 360
              :|||:              |.:.::..::|:   .|.:|...:..:..|:|      |.|
Mouse   254 TLEKLDL--------------TGNEIKAIDLTV---FETMPNLKILLMDNNKLNSLDSKILNSLK 301

  Fly   361 --LSAGGDGDS-DSEPRTAA------ATQGRKTYVV------------------------NMLRN 392
              .:.|..|:. :..||..|      :.|||..:.:                        |:
Mouse   302 SLTTVGLSGNLWECSPRVCALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLCWNL--- 363

  Fly   393 ASNLTILTADMQDAGI-YT--CAAENKAGKVEASVTLAVS-------RRPPEAPWGVRIILLGAV 447
            ::.:|.:....:|... ||  .::....|..|...|..::       ..|..|.:..|:| .|.:
Mouse   364 STTVTAMATTYRDPTTEYTKISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIFTQRVI-TGTM 427

  Fly   448 AALLLVGGSSFAAICLCSLQRR------RKLRLWNSVPPVRRSESYEKIEMT 493
            |.|.    |.|..|.:..:.|:      |::|..:.:...|:..|..::.|:
Mouse   428 ALLF----SFFFIIFIVFISRKCCPPTLRRIRQCSMIQNHRQLRSQTRLHMS 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	52/178 (29%)
		leucine-rich repeat	112..137	CDD:275380	8/46 (17%)
		LRR_8	137..196	CDD:290566	19/58 (33%)
		leucine-rich repeat	138..161	CDD:275380	4/22 (18%)
		leucine-rich repeat	162..185	CDD:275380	9/22 (41%)
		LRR_8	184..245	CDD:290566	21/60 (35%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	11/23 (48%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	10/53 (19%)
		IG_like	328..428	CDD:214653	23/144 (16%)
		Ig	335..425	CDD:143165	22/134 (16%)
Lrrtm2	NP_821072.1	LRR 1	63..83		6/19 (32%)
		LRR	<65..312	CDD:227223	71/292 (24%)
		leucine-rich repeat	66..86	CDD:275380	7/19 (37%)
		LRR 2	86..107		0/20 (0%)
		leucine-rich repeat	87..110	CDD:275380	1/22 (5%)
		LRR 3	110..131		3/20 (15%)
		leucine-rich repeat	111..134	CDD:275380	4/22 (18%)
		LRR 4	134..155		9/20 (45%)
		leucine-rich repeat	135..158	CDD:275380	9/22 (41%)
		LRR 5	158..179		6/20 (30%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		LRR 6	182..203		8/20 (40%)
		leucine-rich repeat	183..206	CDD:275380	11/23 (48%)
		LRR 7	206..227		5/20 (25%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		LRR 8	230..251		11/48 (23%)
		leucine-rich repeat	231..254	CDD:275380	11/50 (22%)
		LRR 9	254..275		5/37 (14%)
		leucine-rich repeat	255..278	CDD:275380	6/39 (15%)
		LRR 10	278..299		3/20 (15%)
		leucine-rich repeat	279..300	CDD:275380	4/20 (20%)
		PCC	284..>351	CDD:188093	12/66 (18%)
		Involved in DLG4-binding. /evidence=ECO:0000250	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930