DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and si:ch211-170a17.1

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_021336930.1	Gene:	si:ch211-170a17.1 / 101884914	ZFINID:	ZDB-LINCRNAG-131127-306	Length:	628	Species:	Danio rerio

Alignment Length:	540	Identity:	124/540 - (22%)
Similarity:	180/540 - (33%)	Gaps:	203/540 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RLPLHLHLLLW-----LLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQ 113
            |:.||..:..|     |......:|...| ||:.|||..:|  .||:|.....|.||..:...|:
Zfish    20 RVMLHTAVSCWQPLLGLALVAVFVGSTLA-CPSRCECSAQS--RSVICHRKRYTAIPDGVPLETR 81

  Fly   114 LLDLSGNEIQLIPDDSFAT---------------------------------------------- 132
            :||||.|.||.:..|.||.
Zfish    82 ILDLSKNRIQAVNPDDFAAYPHIEELDLSGNIIAYVEPGAFNSLYSLHSLSLKSNRIKLLSLGVF 146

  Fly   133 ------------------------------------------------AQLLNLQKVYLARCHL- 148
                                                            :.||:|:.:.|.||:|
Zfish   147 TGLSNLTNLDISDNKVVILVDYMFQDLRNLRSLDVGDNELVYISHRAFSGLLSLESLTLERCNLT 211

  Fly   149 -----------RLIERH------------AFRKL------------------------INLVELD 166
                       .|:..|            :|:||                        :||..|.
Zfish   212 VVPTDALSHLHNLVSLHMRYLTISTLHPYSFKKLFHLRHLEIDNWPSLDVFPANSLHGLNLTTLS 276

  Fly   167 LSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGL 231
            ::...||..|..||:|:..|..|.||.:.|..|......::.:|.:|.|:...|..|...||.|
Zfish   277 VTNTNLSTFPYQALHHLPYLTHLNLSYSRIRTVEGGLLQNLVRLRELRLAGSHLVSIEPYAFQG- 340

  Fly   232 ESSLEWLKL---DGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQ--NIPSG- 290
               :.||:|   ..|||..:..|...:..:|..|.:..|...|.|.|    .|:||:  :|..|
Zfish   341 ---IRWLRLLNISHNRLDTLEKGAFHAPEALQVLLINNNPLVCDCRL----MWLLQRHHSISFGD 398

  Fly   291 IPPTCESPP----RLSGRAWDKLDVDDFACV-PQIVATDTTAHGV-EGRNITMSCYVEGVPQPAV 349
            ..|.|.||.    |.|....:.|..:...|. |:|....|.:..| ||::..::|..||.|:|.:
Zfish   399 TQPECSSPEGSQRRQSKEFKEALLSNYVTCTKPKIRRNRTQSVSVEEGQSAHLNCTAEGTPRPTI 463

  Fly   350 KWL------LKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGI 408
            .|:      |.||                      ..||.     |:.|..:|.|...::||.|:
Zfish   464 SWVSPRKVQLNNR----------------------NHGRV-----MVHNNGSLDIKAVEVQDGGV 501

  Fly   409 YTCAAENKAGKVEASVTLAV 428
            |.|.|.|.||.....|:|:|
Zfish   502 YVCTASNSAGNDTLMVSLSV 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	55/301 (18%)
		leucine-rich repeat	112..137	CDD:275380	12/118 (10%)
		LRR_8	137..196	CDD:290566	23/106 (22%)
		leucine-rich repeat	138..161	CDD:275380	10/70 (14%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	18/63 (29%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	8/23 (35%)
		leucine-rich repeat	235..258	CDD:275380	7/25 (28%)
		LRRCT	267..316	CDD:214507	16/55 (29%)
		IG_like	328..428	CDD:214653	29/106 (27%)
		Ig	335..425	CDD:143165	24/95 (25%)
si:ch211-170a17.1	XP_021336930.1	leucine-rich repeat	80..103	CDD:275380	11/22 (50%)
		PLN00113	<83..>196	CDD:331614	10/112 (9%)
		leucine-rich repeat	104..127	CDD:275380	0/22 (0%)
		leucine-rich repeat	128..151	CDD:275380	0/22 (0%)
		LRR_8	136..186	CDD:316378	0/49 (0%)
		leucine-rich repeat	152..175	CDD:275380	0/22 (0%)
		leucine-rich repeat	176..223	CDD:275380	7/46 (15%)
		LRR_8	207..255	CDD:316378	8/47 (17%)
		leucine-rich repeat	224..247	CDD:275380	5/22 (23%)
		leucine-rich repeat	248..295	CDD:275380	9/46 (20%)
		LRR_8	271..330	CDD:316378	18/58 (31%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..378	CDD:316378	18/62 (29%)
		leucine-rich repeat	320..343	CDD:275380	8/26 (31%)
		leucine-rich repeat	344..363	CDD:275380	6/18 (33%)
		PCC	348..>430	CDD:188093	23/85 (27%)
		I-set	431..521	CDD:254352	32/116 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910