DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and lrrc53

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_021322571.1	Gene:	lrrc53 / 101882576	ZFINID:	ZDB-GENE-131121-432	Length:	838	Species:	Danio rerio

Alignment Length:	1007	Identity:	199/1007 - (19%)
Similarity:	317/1007 - (31%)	Gaps:	349/1007 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LWLLCCCSQLGQLRAECPAVCECKWKS-----GKESVLCLNANLTHIPQPLD----------AGT 112
            |.|||..|.|  :.:|...:|: |.:|     |....|.|...|      :|          :..
Zfish    17 LALLCPSSCL--VCSEDVTICQ-KLRSIIDAPGSTKALMLTDGL------IDSVGSMVFSDLSNM 72

  Fly   113 QLLDLSGNEIQLIPDDSF---------------ATAQLLN---------LQKVYLARCHLRLIER 153
            .:|.||.|.|..|.:::|               .:.|.||         |:.:.|:..||:.|:.
Zfish    73 SVLALSNNAISSITENAFQNLTFLTTLSLDHNHISNQALNSSTFSWLHRLETLQLSNNHLKDIDG 137

  Fly   154 HAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELR---LSGNPILRVPDDAFGHVPQLVKLEL 215
            ..|:..|.|..|.|..|||:::.|....| ::||.|.   ||.|.|:.:..::|..:|.|.:|:|
Zfish   138 SWFQSSIALKTLQLDGNLLTSLNSTTFAH-ADLRNLEILDLSDNLIVTLGRESFRRLPSLRRLDL 201

  Fly   216 SDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRA 280
            |...||. |..||    |.|.||..                     |.|..|.|:|||.||.|.:
Zfish   202 SRNNLSS-APDAF----SYLSWLST---------------------LNLDLNRWSCSCELRELAS 240

  Fly   281 WMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEGVP 345
            ::                             :.|...|:.|
Zfish   241 FL-----------------------------NSFIQAPENV------------------------ 252

  Fly   346 QPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYT 410
                   |.|                         |:|...|| ..|.|..|:|  .:.||   .
Zfish   253 -------LYN-------------------------GQKMACVN-ADNPSVQTVL--QLTDA---N 279

  Fly   411 CAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLW 475
            |...|....||     .|::|...:...:|.:.:..|.:.|...|.:...|.:...:..:|.:|.
Zfish   280 CVPPNSNITVE-----VVAKRSNTSQQYIRNVAIAVVFSFLGGVGITLGIIAIAYHKLSKKFKLM 339

  Fly   476 NSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQ 540
            .     ....:.|:|    .:.|::.....|.|...  ..:.|......|  .:|.|.:..|:
Zfish   340 Q-----EEHGASERI----TSSPEMAQWNFCEGKDT--LSMSHALYNSNY--KSHQPWDREDS-- 389

  Fly   541 AAAIVNPSAGSAQRRNGDYLHVSTH-CDD----------EEEDQQLHHHPQQQPASQHHPHPNQQ 594
                   ..||.:..|    |.:.| |..          |...|:...:.|:...|:|      .
Zfish   390 -------PYGSDELEN----HFTCHKCSSTALTGGKPKRETVLQKTTENLQKNHMSEH------L 437

  Fly   595 QHQQRKGSQGHVVSASGANNSAPLEE--TDLHIPRLIDIGGTDSASSSISSQVDAAARLAGYAGH 657
            .|:|..|:|.|.|          |::  .|:|:.|..:   .|| .|.::||...:.|..|
Zfish   438 AHRQHNGNQQHSV----------LQQRIKDMHLKRQAE---RDS-KSHLASQDFTSQRRGG---- 484

  Fly   658 TWKTTPIATTKI-------------NSPHSKP------VTSAAPSSLNTQA---TPYAHYGNHPA 700
               ...|:..:|             ..|...|      .|.|..|.|..||   ||      .|.
Zfish   485 ---PDDISAVRIQQLALSNHFSALQRGPFRPPNHIYNEETQANHSLLKHQASETTP------RPI 540

  Fly   701 DEMATSVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPNGGLCTLPRKLKT 765
            .:..:.:.|.:..|.....||..|.       ......:.|||.|.          ..|.|.:.
Zfish   541 YQTISCLHCHQTYEYRQAQSNNHDF-------PFTNHSQNRGQMYD----------AMLYRDIL- 587

  Fly   766 SGKYFRNSSDSQSPLLADNSSKYGSSTLGDGSFLNEAMGLGRRYSAESSYANYSSTATYTGGGQR 830
              .|.:..:|.     .|.|.                  ||.:.:::.| ..:..|........|
Zfish   588 --GYEKRDADG-----CDESE------------------LGFKLASQRS-VTFDLTMPEERTADR 626

  Fly   831 ANSFLNLVQSGAHQGKLLPSHLGQKPSLPSSPVQHQRSLSSAATPLLDFSALASRAAGAANTSVA 895
            .|:..:|.:|             |:.|....|.:.:..........|:...|........:.|
Zfish   627 RNNQTSLQKS-------------QRKSSAQKPHKSRGQTKKTLRVKLNLDPLRKNRVHPKSKS-- 676

  Fly   896 AYDYHAAQLERFLEEYRNLQDQLCKMKETC-----------DTIRKKETPLRV--AIGQSAAQLA 947
             .|..|...:|        :::|...|:||           :|:.|::..:||  ::.:...|.:
Zfish   677 -EDSKADDKKR--------KEKLRSKKKTCKKSKEDSVGNEETLNKRDAQMRVSKSVPEETEQNS 732

  Fly   948 DPVMYSAASHSPKPPATSNLKTKTLLPGQPPD 979
            .|......:......:.|..:|.::|...|||
Zfish   733 TPAEGETQTSDAVFSSISEAQTPSVLTISPPD 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	49/183 (27%)
		leucine-rich repeat	112..137	CDD:275380	8/39 (21%)
		LRR_8	137..196	CDD:290566	22/70 (31%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	22/63 (35%)
		leucine-rich repeat	186..209	CDD:275380	8/25 (32%)
		leucine-rich repeat	210..234	CDD:275380	9/23 (39%)
		leucine-rich repeat	235..258	CDD:275380	3/22 (14%)
		LRRCT	267..316	CDD:214507	9/48 (19%)
		IG_like	328..428	CDD:214653	16/99 (16%)
		Ig	335..425	CDD:143165	16/89 (18%)
lrrc53	XP_021322571.1	LRR_8	49..106	CDD:316378	11/62 (18%)
		leucine-rich repeat	51..71	CDD:275380	4/25 (16%)
		leucine-rich repeat	72..95	CDD:275380	7/22 (32%)
		LRR_8	96..156	CDD:316378	14/59 (24%)
		leucine-rich repeat	96..121	CDD:275380	3/24 (13%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		LRR_8	146..206	CDD:316378	21/60 (35%)
		leucine-rich repeat	146..171	CDD:275380	9/25 (36%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		leucine-rich repeat	196..218	CDD:275380	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910