DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and lrrc17

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_004913080.1	Gene:	lrrc17 / 101732309	XenbaseID:	XB-GENE-1010987	Length:	428	Species:	Xenopus tropicalis

Alignment Length:	293	Identity:	69/293 - (23%)
Similarity:	104/293 - (35%)	Gaps:	93/293 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LLWLLCCCSQLGQLRAECPAVCEC-KWKSGKESVLCLNANLT---------HIP-QPLDAGTQLL 115
            ||.|||.|.           :.|| |.||.:|:.   ..|.|         :.| .|.:....|
Frog     6 LLMLLCFCK-----------ISECRKTKSNRENG---KPNRTKKTSSTVKRYAPGLPCETYIYL- 55

  Fly   116 DLSGNEIQLIPDDSFATAQL----LNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIP 176
                ||..|...:...|:.|    .:|..:.|||..:|:::.:||.|...:..|||.||.:..|.
Frog    56 ----NEKYLDCQEKRQTSVLPAWPEDLIHILLARNLIRILKNNAFSKFQKVKSLDLQQNEIIKIE 116

  Fly   177 SLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLD 241
            :||.|.:..|..|.|..|.|..:.::.|.|:|.|..|.|.|
Frog   117 NLAFYGLKRLTTLLLQHNKIKVLSEEVFIHLPLLSYLRLYD------------------------ 157

  Fly   242 GNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWM-LQQNIPSGIPPTCESPPRLSGRA 305
                                     |.|:|:|.|..|...: :.:|...|....||:|..:.|..
Frog   158 -------------------------NPWDCNCELESLVTLLKIPRNRNLGNYAKCETPIEMKGLK 197

  Fly   306 WDKLDVDDFACVPQIVATDTT--AHGVEGRNIT 336
            ...:.       |:::..|.|  ...:||..:|
Frog   198 LKTVS-------PELICQDRTMEPQHIEGPKVT 223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	35/160 (22%)
		leucine-rich repeat	112..137	CDD:275380	6/28 (21%)
		LRR_8	137..196	CDD:290566	21/58 (36%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	9/22 (41%)
		LRR_8	184..245	CDD:290566	12/60 (20%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	4/23 (17%)
		leucine-rich repeat	235..258	CDD:275380	0/22 (0%)
		LRRCT	267..316	CDD:214507	12/49 (24%)
		IG_like	328..428	CDD:214653	3/9 (33%)
		Ig	335..425	CDD:143165	1/2 (50%)
lrrc17	XP_004913080.1	leucine-rich repeat	58..77	CDD:275380	3/18 (17%)
		leucine-rich repeat	78..101	CDD:275380	8/22 (36%)
		LRR	<86..>319	CDD:227223	43/194 (22%)
		LRR_8	101..159	CDD:338972	21/106 (20%)
		leucine-rich repeat	102..125	CDD:275380	9/22 (41%)
		leucine-rich repeat	126..149	CDD:275380	7/22 (32%)
		leucine-rich repeat	150..211	CDD:275380	18/116 (16%)
		leucine-rich repeat	212..259	CDD:275380	3/12 (25%)
		leucine-rich repeat	260..283	CDD:275380
		LRR_8	262..316	CDD:338972
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..331	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910