DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Islr2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_003750572.2	Gene:	Islr2 / 100910729	RGDID:	6497037	Length:	746	Species:	Rattus norvegicus

Alignment Length:	866	Identity:	206/866 - (23%)
Similarity:	303/866 - (34%)	Gaps:	235/866 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIP 126
            |.|.|     ||..|| ||..|.|..|...:...|....|..:|:.|.|....|.||.|:|.::.
  Rat    10 LAWAL-----LGVARA-CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLR 68

  Fly   127 DDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRL 191
            ..:|  ..:..:..::||...:|.:|..|...|..|..||||.||:|..|...|.::|.|:.|::
  Rat    69 RGAF--VNVTQVTSLWLAHSEVRTVESGALAVLSQLKNLDLSHNLISNFPWSDLRNLSALQLLKM 131

  Fly   192 SGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSL 256
            :.|.:..:|.||.|.:|                         .|..|:::.|||..:..||..:|
  Rat   132 NHNRLGSLPRDALGALP-------------------------DLRSLRINNNRLRTLEPGTFDAL 171

  Fly   257 ASLHGLELARNTWNCSCSLRPLRAWMLQQNI----PSGIPPTCESPPRLSGRAWDKLDVDDFACV 317
            ::|..|:|..|.::|||.|..|:||.....:    |..|  .|.|||.|.|....:|..  ..|.
  Rat   172 SALSHLQLYHNPFHCSCGLVWLQAWAASTRVSLPEPDSI--ACASPPELQGVPVHRLPA--LPCA 232

  Fly   318 PQIVATDT----TAHGV---EGRNITMSCYVEGVPQPAVKW---------LLKNRLIANLSAG-- 364
            |..|....    .|.|.   .|.:..:.|..||.|.|.::|         :|...:::....|
  Rat   233 PPSVRLSAEPPPEAPGTPLRAGLSFLLHCVAEGHPTPRLQWQLQIPGGTVVLVPPVLSKEEDGGE 297

  Fly   365 ------GDGDSDSEPRTAAAT----------QGRKTYVVNMLRNASNLT-ILTADMQDAGIYTCA 412
                  ||||.|...:|.|.|          .....::.  |.|.|.|. :|:|  ::||||||.
  Rat   298 KVDDGEGDGDEDQPTQTEAPTPTPAPAWPAPPATPRFLA--LANGSLLVPLLSA--KEAGIYTCR 358

  Fly   413 AENKAGKVEAS--VTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLW 475
            |.|:.|....|  ||:|.:..|..||        |.        |....|....|.::.......
  Rat   359 AHNELGTNSTSLRVTVAAAGPPKHAP--------GT--------GEEPDAQAPTSERKATTKGRS 407

  Fly   476 NSVPPVR-----RSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQ--GYLRAAHTPL 533
            |||.|.:     :.:...::.:...|..:|         ..|      |.|||  |.:.|  .|:
  Rat   408 NSVLPFKPEGKTKGQGLARVSILGETEAEL---------EET------DEEEQMGGQIPA--DPM 455

  Fly   534 NDNDAGQAAAIVNPSAGSAQRRNGDYLHVSTHCDDEEEDQQLH---------------HHPQQQP 583
            .:...|..    :||.           :||.|..::..|.:.|               ...|..|
  Rat   456 GEKHCGHG----DPSR-----------YVSNHAFNQSSDLKPHVFELGVIALDVAEREARVQLTP 505

  Fly   584 -ASQHHPHPNQQQHQQRKGSQGHVVSASGANNSA--PLEETDLHIPRLIDI----GGTDSASSSI 641
             |::..|.|:               .||||....  ||        ||:.:    |||....|.:
  Rat   506 LAARWGPGPD---------------GASGARRPGRRPL--------RLLYLCPAGGGTAVQWSRV 547

  Fly   642 SSQVDA--------------AARLAGYAGHTWKTTPIATTKINSPHSKPVTSAAPSSLNTQATPY 692
            ...|:|              ...|||.|.|   ...:.:||...|....:.:.:...|.....|.
  Rat   548 EEGVNAYWFRGLRPGTNYSVCLALAGEACH---VQVVFSTKKELPSLLVIVTVSVFLLVLATVPL 609

  Fly   693 -----AH-YGNHPA------------DEMATSVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQQE 739
                 .| ...||.            |.|...:...       ||..       |.|..::....
  Rat   610 LGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAAD-------FDPR-------ASYLESEKSYP 660

  Fly   740 GRGQ-GYAQATTTPNGGLCTLPRKLKTSGKYFRNSSDSQSPLLADNSSKYGSSTLGDGSFLNEAM 803
            .||: |..:....|..||.....:...||...|..|.:...|: ::.||........||..::.:
  Rat   661 ARGEAGGEEPEEVPEEGLDEDVEQGDPSGDLQREESLAACSLV-ESQSKANQEEFEAGSEYSDRL 724

  Fly   804 GLGRR--YSAESSYANYSSTA 822
            .||..  ..|:....||..||
  Rat   725 PLGAEAVNIAQEINGNYRQTA 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	43/156 (28%)
		leucine-rich repeat	112..137	CDD:275380	6/24 (25%)
		LRR_8	137..196	CDD:290566	20/58 (34%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	10/22 (45%)
		LRR_8	184..245	CDD:290566	12/60 (20%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	0/23 (0%)
		leucine-rich repeat	235..258	CDD:275380	8/22 (36%)
		LRRCT	267..316	CDD:214507	17/52 (33%)
		IG_like	328..428	CDD:214653	36/132 (27%)
		Ig	335..425	CDD:143165	32/119 (27%)
Islr2	XP_003750572.2	leucine-rich repeat	37..53	CDD:275380	4/15 (27%)
		leucine-rich repeat	54..77	CDD:275380	6/24 (25%)
		leucine-rich repeat	78..101	CDD:275380	6/22 (27%)
		LRR_8	100..160	CDD:404697	22/84 (26%)
		leucine-rich repeat	102..125	CDD:275380	10/22 (45%)
		leucine-rich repeat	126..149	CDD:275380	8/47 (17%)
		leucine-rich repeat	150..173	CDD:275380	8/22 (36%)
		PCC	155..>229	CDD:188093	26/77 (34%)
		Ig	249..374	CDD:416386	34/128 (27%)
		Ig strand B	257..264	CDD:409353	1/6 (17%)
		Ig strand C	270..278	CDD:409353	1/7 (14%)
		Ig strand C'	280..287	CDD:409353	1/6 (17%)
		Ig strand D	333..337	CDD:409353	0/5 (0%)
		Ig strand E	340..345	CDD:409353	2/4 (50%)
		Ig strand F	353..361	CDD:409353	6/7 (86%)
		Ig strand G	364..374	CDD:409353	3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910