DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Elfn2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_006242103.2	Gene:	Elfn2 / 100910536	RGDID:	1559693	Length:	820	Species:	Rattus norvegicus

Alignment Length:	934	Identity:	200/934 - (21%)
Similarity:	295/934 - (31%)	Gaps:	355/934 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LLCCCSQLGQLRAECPAVCECKW--KSGKESV---LCLNANLTH--IPQPLDAGTQLLDLSGNEI 122
            |||.| |.|.:.|:|       |  :..|..|   :|......:  |||.:::....|.|:.|::
  Rat    11 LLCVC-QPGAVHADC-------WLIEGDKGYVWLAICSQNQPPYETIPQHINSTVHDLRLNENKL 67

  Fly   123 QLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELR 187
            :.:...|.  .:..||..:.|.:..:..||..||....:|..|.|..|.||.:....|..:|.|:
  Rat    68 KAVLYSSL--NRFGNLTDLNLTKNEISYIEDGAFLGQTSLQVLQLGYNRLSNLTEGMLRGMSRLQ 130

  Fly   188 ELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGT 252
            .|.:..|.|..|...||...|.|:.::||..|||                 :|||        .|
  Rat   131 FLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLS-----------------RLDG--------AT 170

  Fly   253 ITSLASLHGLELARNTWNCSCSLRPLRAWMLQ-QNIPSGIPP-TCESP------PRLSGRAWDKL 309
            ..|||||...|||.|.:||.|.|....||::. .|:...... .||||      |.|..|.:..|
  Rat   171 FASLASLMVCELAGNPFNCECDLFGFLAWLVVFNNVTKNYDRLQCESPREFAGYPLLVPRPYHSL 235

  Fly   310 DV----------------------------------------DDFACV--PQIVATDTTA----- 327
            :.                                        |:...|  |....||.:|
  Rat   236 NAITVLQAKCRNGSMPARPVSHPTPYSTDAQREPDENSGFNPDEILSVEPPASSTTDASAGPAIK 300

  Fly   328 -HGVEGRNITMSCYVEGVPQPAVK---------------WLLKNRL-IANLSAGGDGDSDSEPRT 375
             |.|   ..|.:..|..:|.|..|               ..|||:. |..|.           :.
  Rat   301 LHQV---TFTSATLVVIIPHPYSKMYVLVQYNNSYFSDVMTLKNKKEIVTLD-----------KL 351

  Fly   376 AAATQGRKTYVVNMLRNAS--NLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSRRPPEAPWG 438
            .|.|:  .|:.|..|||:.  |.|.||...:|                    |....:.|.....
  Rat   352 RAHTE--YTFCVTSLRNSRRFNHTCLTFTTRD--------------------LVPGDQVPSTSTT 394

  Fly   439 VRII--LLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLG 501
            ...|  :||.:..:::|.|:.:  .||    |:|:::           |..:|.....:|..::.
  Rat   395 THYIMTILGCLFGMVIVLGAVY--YCL----RKRRMQ-----------EEQQKSVNVKKTILEMR 442

  Fly   502 GGASCGGGSATGAGLFHDAE---EQGYLRAAHTPLNDNDAGQ--------AAAIVNPSAGSAQRR 555
            .||....||     :.|.|:   |...|..|......:..|:        .|.:..|...:
  Rat   443 YGADVDAGS-----IVHAAQKLVEPPVLPVARMSSIPSMIGEKLPASKGLEAGLDTPKVAT---- 498

  Fly   556 NGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASGANNSAPLEE 620
            .|:|:.|.|                                           .|:|.:.:.|  |
  Rat   499 KGNYIEVRT-------------------------------------------GAAGDSLARP--E 518

  Fly   621 TDLHIPRLIDIGGTDSASSSISSQV----------------DAAARLAGYAG-------HTWKTT 662
            .||  |.:.:..|:.:..|:|:.:|                |:|:.|.|.:|       ...::.
  Rat   519 DDL--PEIENGQGSAAEISTIAKEVDKVNQIINNCIDALKLDSASFLGGGSGGGDSDLAFECQSL 581

  Fly   663 PIATTKINSPHSKPVTSAAPSSLNTQATPYAHYGNHP------ADEMATSVFCSEG-----QESD 716
            |.||..  |..:.|.....||.|   :.||....:||      ||...|...||..     :.:.
  Rat   582 PAATAA--SSTATPGALERPSFL---SPPYKESSHHPLQRQLSADAAVTRKTCSVSSSGSIKSAK 641

  Fly   717 LFDSNYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPNGGLCTLPRKLKTSGKYFRNSSDSQSPL- 780
            :|..:.||                        ..||.|       ..|:..||....|...|||
  Rat   642 VFSLDVPD------------------------HPTPTG-------LAKSDSKYIEKGSPLNSPLD 675

  Fly   781 ---LADNSSKYGSSTLGDG-----------------------------------SFLNEAMGLGR 807
               |....|. |||..|.|                                   ||| :.:...:
  Rat   676 RLPLVPTGSS-GSSGGGGGIHHLEVKPAYHCSEHRHSFPALYYEEGADSLSQRVSFL-KPLTRSK 738

  Fly   808 RYSAESS------YANYSSTATYT 825
            |.|..|.      |:.|||:..|:
  Rat   739 RDSTYSQLSPRHYYSGYSSSPEYS 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	45/156 (29%)
		leucine-rich repeat	112..137	CDD:275380	4/24 (17%)
		LRR_8	137..196	CDD:290566	18/58 (31%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		LRR_8	184..245	CDD:290566	18/60 (30%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	6/23 (26%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	17/96 (18%)
		IG_like	328..428	CDD:214653	25/117 (21%)
		Ig	335..425	CDD:143165	22/107 (21%)
Elfn2	XP_006242103.2	leucine-rich repeat	60..80	CDD:275378	4/21 (19%)
		LRR_8	80..139	CDD:404697	18/58 (31%)
		leucine-rich repeat	81..104	CDD:275378	6/22 (27%)
		leucine-rich repeat	105..128	CDD:275378	7/22 (32%)
		LRR_8	127..187	CDD:404697	28/84 (33%)
		leucine-rich repeat	129..152	CDD:275378	7/22 (32%)
		leucine-rich repeat	153..166	CDD:275378	6/29 (21%)
		PCC	157..>227	CDD:188093	30/94 (32%)
		leucine-rich repeat	177..189	CDD:275378	5/11 (45%)
		leucine-rich repeat	200..226	CDD:275380	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334992
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840