DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and lrrc4bb

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_003201401.1	Gene:	lrrc4bb / 100535350	ZFINID:	ZDB-GENE-091116-44	Length:	726	Species:	Danio rerio

Alignment Length:	789	Identity:	190/789 - (24%)
Similarity:	265/789 - (33%)	Gaps:	290/789 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LHLLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQ 123
            :.||||......:|.:....|||:|.|..::.:  |:|...:|..:||.:.:.|:.|:|..|.||
Zfish    19 VQLLLWPHLLGPRLAEASPACPALCSCSNQASR--VICTKKSLNEVPQSISSNTRYLNLQENSIQ 81

  Fly   124 LIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRE 188
            :|..|:|  ..|.:|:.:.|::..:|.||..||..|.||:.|:|..|.|..:||.|..::|:|||
Zfish    82 VIRSDTF--KHLNHLEILQLSKNQIRQIEVGAFNGLPNLITLELFDNRLPLVPSQAFEYLSKLRE 144

  Fly   189 LRLSGNPILRVPDDAFGHVPQLVKLELSDCR-LSHIAVRAFAGLES------------------- 233
            |.|..|||..:|..||..||.|.:|:|.:.| ||.|:..||.||.:
Zfish   145 LWLRNNPIETLPAYAFHRVPSLRRLDLGELRKLSFISEAAFEGLLNLRFLNLGMCGLKDVPNLTP 209

  Fly   234 --SLEWLKLDGNRLSEVRSGTITSLA----------------------------------SLHGL 262
              .||.|:|.||:|..||.|:...|.                                  |||.|
Zfish   210 LVRLEELELSGNQLGVVRPGSFQGLVSLRKLWLMHSRISVIERNAFDDLKNLEELNLSHNSLHSL 274

  Fly   263 --------------ELARNTWNCSCSLRPLRAWMLQQNIP--SGIPPTCESPPRLSGRAWDKLDV 311
                          .|..|.|.|:|.:..| :|.|::.:|  |.....|.:||...||....||.
Zfish   275 PHDLFTPLQQLERVHLNHNPWVCNCDVLWL-SWWLKETVPDNSTCCARCHAPPGTKGRYIGDLDQ 338

  Fly   312 DDFAC-VPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRT 375
            .||.| .|.||...|..:..||....:.|.. |....:|.||                   .|..
Zfish   339 RDFTCYAPVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWL-------------------TPNG 383

  Fly   376 AAATQGRKTYVVNMLRNAS-NLTILTADMQDAGIYTCAAENKAGKVEASVTLAVS---------- 429
            ...|.|.....:::|.:.: |.|.:|  |||.|.|||...|.||...|:..|.||
Zfish   384 TLMTHGAYKVRISVLHDGTLNFTNVT--MQDTGPYTCMVTNSAGNTTATAVLNVSAPDPGNGYSY 446

  Fly   430 -------------------------------------------------------RRPPEAPWGV 439
                                                                   .|.|:.|:.|
Zfish   447 FTTVTVETVETGQEGHDSPARQFVNETFISFPGPTAASTSAGPTGSMLSSLSPRATRAPDRPFTV 511

  Fly   440 RI-----------------ILLGAVAALLLVGGSSFAAICLCSLQRRRKL-RLWNSVPPVRRSES 486
            .|                 |::|...|:..:     ||:.|....:.||. :|.....|.|..|
Zfish   512 SITDVANLSGLEDVMKTTKIIIGCFVAITFM-----AAVMLVVFYKLRKQHQLHKHHGPARAIE- 570

  Fly   487 YEKIEMTARTRPDLG--GGAS--CGG-----GSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAA 542
                  ......::|  ||||  .||     |:.||.|       .|.....|.|         .
Zfish   571 ------IINVEDEIGSAGGASGITGGSTVHTGAGTGGG-------SGQSPRIHDP---------E 613

  Fly   543 AIVNPSAGSAQRRNGDYLHVSTHCDDEEEDQQLHH-------------------HPQQQ------ 582
            .:..||.|.|...|..|              :.||                   :|..|
Zfish   614 IMTLPSVGQADHLNHYY--------------KAHHFNNNVLGLNMTTGMLNNKPNPSSQNQASTL 664

  Fly   583 ---PASQHHPHPNQQQ-------------HQQRKGSQGHVVSASGANNSAPLEETDLHIPRLIDI 631
               ||....|:|....             |...|| ..||          |..:|:   |.|:..
Zfish   665 KMGPAGDLGPNPGSISPPLPIPIPMAMTFHGSLKG-HSHV----------PNVQTE---PLLLSN 715

  Fly   632 GGTDSASSS 640
            |..:|...:
Zfish   716 GSKESVQET 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	68/226 (30%)
		leucine-rich repeat	112..137	CDD:275380	10/24 (42%)
		LRR_8	137..196	CDD:290566	24/58 (41%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	31/82 (38%)
		leucine-rich repeat	186..209	CDD:275380	12/22 (55%)
		leucine-rich repeat	210..234	CDD:275380	11/45 (24%)
		leucine-rich repeat	235..258	CDD:275380	11/56 (20%)
		LRRCT	267..316	CDD:214507	18/50 (36%)
		IG_like	328..428	CDD:214653	26/100 (26%)
		Ig	335..425	CDD:143165	23/90 (26%)
lrrc4bb	XP_003201401.1	LRRNT	38..72	CDD:214470	11/35 (31%)
		LRR_8	68..128	CDD:290566	23/61 (38%)
		leucine-rich repeat	70..93	CDD:275380	10/24 (42%)
		LRR_RI	85..293	CDD:238064	61/209 (29%)
		leucine-rich repeat	94..117	CDD:275380	8/22 (36%)
		leucine-rich repeat	118..141	CDD:275380	8/22 (36%)
		LRR_8	140..196	CDD:290566	25/55 (45%)
		leucine-rich repeat	142..165	CDD:275380	12/22 (55%)
		leucine-rich repeat	166..190	CDD:275380	11/23 (48%)
		leucine-rich repeat	191..212	CDD:275380	0/20 (0%)
		LRR_8	212..271	CDD:290566	11/58 (19%)
		leucine-rich repeat	213..236	CDD:275380	11/22 (50%)
		leucine-rich repeat	237..260	CDD:275380	0/22 (0%)
		leucine-rich repeat	261..282	CDD:275380	4/20 (20%)
		TPKR_C2	293..343	CDD:301599	18/50 (36%)
		IG_like	352..435	CDD:214653	27/104 (26%)
		Ig	360..435	CDD:299845	25/96 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12164
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	1	0.900	-	-		OOG6_104601
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810