DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and tril

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_002933436.2	Gene:	tril / 100498304	XenbaseID:	XB-GENE-6050227	Length:	872	Species:	Xenopus tropicalis

Alignment Length:	793	Identity:	169/793 - (21%)
Similarity:	275/793 - (34%)	Gaps:	221/793 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQP----LDAGTQLLDLSGNEIQLI 125
            :|..|:....:..:|...|:|:   .::.|||.|..|..:|:.    ..:.|:...|.||.|..|
Frog    11 VLLTCTLARSVEPKCLEPCDCQ---HQQHVLCSNRGLLSVPKSSHMLSSSATKTFSLGGNFIANI 72

  Fly   126 PDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELR 190
            ....|  .|...||::.|....:..|...||.||..|.||.|..|||:.:...||..:.:|:.|.
Frog    73 SALDF--VQFPQLQRLDLQYNRIGSIHPKAFEKLTELEELYLGNNLLATLAPGALAPLRKLKVLN 135

  Fly   191 LSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITS 255
            ::||.:..:...:|.::..|:||.|....:.::....|:.| |:|.:|.|:.|:::.:.....|.
Frog   136 VNGNRLHNISRVSFSNLAALIKLRLDGNDIQNLQGSPFSAL-SNLLYLHLENNKITNISKNAFTG 199

  Fly   256 LASLHGLELARNTWNCSCSLR-----PLRAW--------MLQQNIPS---GIPPTCESPPRLSGR 304
            |..|..|.|:.|.   ...||     ||||.        .|||..||   |:       .|||..
Frog   200 LGKLRLLSLSGNP---QSFLRQPTFLPLRALSTLTMAGNQLQQLGPSLFNGL-------QRLSRL 254

  Fly   305 AWDKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEG-----VPQPAVKWLLKNRLIANLSAG 364
            ......:       .::.|.|..    |.::....:::|     :|: .|...|.|..:.|||.
Frog   255 VLSSNQI-------SVIQTKTFL----GLDLLQELHLDGNKLVQLPE-GVLVPLHNLEVLNLSR- 306

  Fly   365 GDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAVS 429
             :..|...|.|              .:....|.:|  |:|...:...:.:..||
Frog   307 -NAISHLHPET--------------FKGLMRLRVL--DLQHNMLRYLSGQTFAG----------- 343

  Fly   430 RRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSL------------QRRRKLRLWNSVPPVR 482
                           ..|...|.:.|:.::  |.|.|            .|.|.|.::
Frog   344 ---------------NPVLYRLQLDGNRWS--CDCQLLDLKHWILGTLHSRSRMLTVF------- 384

  Fly   483 RSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYL------RAAHTPLNDNDAGQ- 540
             .:.:|..::                     ||.:.|..|..||      |.:.||     |||
Frog   385 -VQCFEPQKV---------------------AGKYLDYLEDSYLWDVGGCRISTTP-----AGQE 422

  Fly   541 ---AAAIVNPSAGSAQRRNGDY-LHVSTHCDD-------EEEDQQLHHHP------------QQQ 582
               .:.:.:.:.|..|.|.||. |.|.|..|:       ||:..||...|            :||
Frog   423 QMMTSTLSDGNIGVHQARKGDIDLIVVTGADNLRVQPKTEEKSLQLPTPPSEVSPALETLALRQQ 487

  Fly   583 ------PASQHH--PHPNQQQHQQRKGSQGHVVSASGANNSAPLEETDLHIPRLIDIGGTDSASS 639
                  |:|.:.  ...|:.....|||....|.:::..:....|....:|        .|.|...
Frog   488 ALVTKWPSSTNKDGTAKNRGLETSRKGKGKSVKNSAEHSRKLHLVAQPVH--------PTQSKVK 544

  Fly   640 SISSQVDAAARLA--GYAGHTWKTTPIATTKI--------------------NSP--HSKPVTSA 680
            .:|..:.|::.|.  ..:.|:.|...:.|..:                    :.|  |..|.|..
Frog   545 QVSVLIPASSNLPPNSESMHSEKPVRLDTPSVVPNLEDVRSVFTTLQHDDTTDKPIHHDNPATKT 609

  Fly   681 APSSLNTQATP----YAHYGN--HPADEMATSVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQQE 739
            ...|.:....|    :...|:  |||.|....|.......||..:.|...|::::..:|..:...
Frog   610 LHLSHSDTLLPNYNSFQQAGDPMHPAAETLPQVAPFPSLLSDPCEFNKLYLVNLSVESVGSSTAR 674

  Fly   740 GRGQGYAQATTTP 752
            .|.|..:..|..|
Frog   675 VRWQTLSAHTRGP 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	46/156 (29%)
		leucine-rich repeat	112..137	CDD:275380	8/24 (33%)
		LRR_8	137..196	CDD:290566	21/58 (36%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	9/22 (41%)
		LRR_8	184..245	CDD:290566	16/60 (27%)
		leucine-rich repeat	186..209	CDD:275380	5/22 (23%)
		leucine-rich repeat	210..234	CDD:275380	6/23 (26%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	16/64 (25%)
		IG_like	328..428	CDD:214653	18/104 (17%)
		Ig	335..425	CDD:143165	17/94 (18%)
tril	XP_002933436.2	leucine-rich repeat	35..58	CDD:275378	6/22 (27%)
		leucine-rich repeat	59..82	CDD:275380	8/24 (33%)
		leucine-rich repeat	83..106	CDD:275380	8/22 (36%)
		internalin_A	84..>375	CDD:380193	79/359 (22%)
		leucine-rich repeat	107..130	CDD:275380	9/22 (41%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		leucine-rich repeat	155..178	CDD:275380	6/23 (26%)
		leucine-rich repeat	179..202	CDD:275380	6/22 (27%)
		leucine-rich repeat	203..226	CDD:275380	8/25 (32%)
		leucine-rich repeat	227..250	CDD:275380	6/29 (21%)
		leucine-rich repeat	251..274	CDD:275380	5/33 (15%)
		leucine-rich repeat	275..298	CDD:275380	4/23 (17%)
		leucine-rich repeat	299..320	CDD:275380	6/36 (17%)
		leucine-rich repeat	323..346	CDD:275380	6/50 (12%)
		fn3	662..737	CDD:394996	5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910