DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and elfn1

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_017953108.1	Gene:	elfn1 / 100495697	XenbaseID:	XB-GENE-6051278	Length:	803	Species:	Xenopus tropicalis

Alignment Length:	940	Identity:	182/940 - (19%)
Similarity:	293/940 - (31%)	Gaps:	334/940 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LLLWLLCCCSQL--GQLRAECPAVCECKW--KSGKESV---LCLNANLTH--IPQPLDAGTQLLD 116
            |.||:|...:.:  |:::|:|       |  :..|..|   :|......:  |||.:::....|.
Frog    12 LCLWVLALLTLIYTGKVQADC-------WLIEGDKGFVWLAICSQNQPPYESIPQHINSTIVDLR 69

  Fly   117 LSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALY 181
            |:.|:|:.:...|.  ::..||..:.|.:..:..||..||....||..|.|..|.|..:....|.
Frog    70 LNENKIKSVHYSSL--SRFGNLTYLNLTKNDVSYIEDGAFAGQFNLQVLQLGYNRLRNLTEGILR 132

  Fly   182 HVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLS 246
            .:::|..|.|..|.|..|..:||...|.::.::||                         .||:.
Frog   133 GLNKLEYLYLQANLIETVTPNAFWECPNIMNIDLS-------------------------MNRIQ 172

  Fly   247 EVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWM------------LQQNIP----------- 288
            .:.|.|..||..|...||..|.:.|||.|.....|:            :|.:.|
Frog   173 RLDSSTFASLNKLTVCELYSNPFYCSCELLGFLEWLQKFTNMTRTFDRMQCDSPPDYIGYYLLGQ 237

  Fly   289 -----------------------------------SGIP-PTCESPPRLSGRAWDKL-DVDDFAC 316
                                               :|.| |.|......||.....| ||...:.
Frog   238 GQTKYRNALGMLSALCADGSYTPRTRFITPKYEVTTGPPDPGCSEEECFSGDGTTPLIDVHTPSI 302

  Fly   317 VPQI---VATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIA-NLSAGGDGDSDSEPRTAA 377
            .|:.   |..:|..|       |.:..|..:|.|..|..:   |:. |.|...|....:..:...
Frog   303 NPKFSLKVNLNTETH-------TDAVLVAEIPSPYSKMYI---LVQYNNSFFTDIQKLNSEKEFI 357

  Fly   378 ATQGRK-----TYVVNMLRNASNLTILTADMQDAGIYTCAA--ENKAGKVEASVTLAVSRRPPEA 435
            ..:|.|     ||.|..:|||....           :||.|  .....|.|:..|       |..
Frog   358 KLEGLKANTNYTYCVASIRNALRFN-----------HTCIAFYTRSHTKTESVPT-------PST 404

  Fly   436 PWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDL 500
            .....:.:||.:..::::.|    .:..|..::|:|            .|.::|
Frog   405 ATHYIMTILGCLFGMVIILG----IVYYCLRKKRQK------------EEKHKK----------- 442

  Fly   501 GGGASCGGGSATGAGLFHDAEEQGYLRAAHTP-LNDNDAGQ--AAAIVN-----PSAGSAQR--- 554
                  .|||...|.:     |..|.....|| :.....||  :|..::     ||.|..::
Frog   443 ------SGGSMKKAII-----ELKYGPEMETPSITQLSQGQMMSAETISRIQYLPSVGEVEQYKL 496

  Fly   555 ---------RNGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSAS 610
                     ..|:|:.|.|....|..|.:|...|..|                          :|
Frog   497 IETSETPKATKGNYMEVRTGDQPERRDCELSMPPDTQ--------------------------SS 535

  Fly   611 GANNSAPLEETDLHIPRLIDIGGTDSASSSISSQVDAAARLAGYAGHTWKTTPIATTKINSPHSK 675
            .|..|...:|             .|..:..|::.:||...              .:|......|.
Frog   536 VAEISTIAKE-------------VDKVNQIINNCIDALKS--------------ESTSFQGVKSG 573

  Fly   676 PVTSAAPS-SLNTQATPYAHYGNHPADEMATSVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQQE 739
            .|::|.|. .|.::..|..|                 |..|.::..:|...|          |:.
Frog   574 AVSTAEPQLVLISEQIPSKH-----------------GFLSPVYKESYSHPL----------QRH 611

  Fly   740 GRGQGYAQATTTPNGGLCTLPRKLKTSG-------KYFRNSSDSQSPLLADNSSKYGSSTLGDGS 797
            ...:|.|:.::|.:.|....||..::.|       ||...:|.:...:|.
Frog   612 HSMEGPAKRSSTSSSGSIRSPRSFRSEGSAHKSEAKYIEKTSPTTDTILT--------------- 661

  Fly   798 FLNEAMGLGRRYSAESSYANYSSTATYTGGGQRANSFLNLVQSGAHQGKLLP-SHL-GQKPSL-- 858
             :..|..:.|        |.......||   :..:|:....||...|...:| .:| |:|||:
Frog   662 -VTPAAAILR--------AEAEKIRQYT---EHRHSYPGSHQSEQQQPPPIPHDNLGGRKPSILE 714

  Fly   859 -------------PSSPVQHQRSLSSAATP 875
                         ..||  |..:||..::|
Frog   715 PLTRPRPRELAYSQLSP--HYHNLSYTSSP 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	39/156 (25%)
		leucine-rich repeat	112..137	CDD:275380	5/24 (21%)
		LRR_8	137..196	CDD:290566	18/58 (31%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	12/60 (20%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	2/23 (9%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	17/108 (16%)
		IG_like	328..428	CDD:214653	24/107 (22%)
		Ig	335..425	CDD:143165	22/97 (23%)
elfn1	XP_017953108.1	LRR	<63..>194	CDD:227223	39/157 (25%)
		leucine-rich repeat	68..88	CDD:275378	5/21 (24%)
		LRR_8	88..147	CDD:404697	18/58 (31%)
		leucine-rich repeat	89..112	CDD:275378	6/22 (27%)
		leucine-rich repeat	113..136	CDD:275378	6/22 (27%)
		leucine-rich repeat	137..160	CDD:275378	8/22 (36%)
		leucine-rich repeat	161..174	CDD:275378	4/37 (11%)
		LRRCT	193..>231	CDD:214507	8/37 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910