DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and lrig2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_002932176.2	Gene:	lrig2 / 100494845	XenbaseID:	XB-GENE-922899	Length:	1078	Species:	Xenopus tropicalis

Alignment Length:	1167	Identity:	217/1167 - (18%)
Similarity:	349/1167 - (29%)	Gaps:	497/1167 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PRLPLHLHLLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLD---AGTQL 114
            ||:||.     :|....:::..|.|.|     ....|....||.||.|..::.||..   ...|.
Frog   148 PRMPLK-----YLNLSNNRIATLEAGC-----FDNLSSSLLVLKLNRNRINVIQPKSFKLPHLQY 202

  Fly   115 LDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLA 179
            |:|..|.|:::  :|.....|.:|:.:.|.|..:..:...||..|.|:.:|:|..|.::.|....
Frog   203 LELRRNRIKIV--ESLTFQGLDSLKSLKLQRNGIVKLMDGAFFGLDNMEQLELEYNNVTDINKGW 265

  Fly   180 LYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELS------------------------DCRL 220
            ||.:..|::|.:|.|.:.|:..||:....:|:.|:||                        |.|:
Frog   266 LYGLRSLQQLYISQNAVHRISPDAWEFCQKLLDLDLSYNQLNRLDDFAFVGLSSLEKINLGDNRI 330

  Fly   221 SHIAVRAFAGL---------ESSLEW-----------------LKLDGNRLSEVRSGTITSLASL 259
            :|||...|.||         .:.:.|                 |.|.||::..:.....|.|.||
Frog   331 NHIAEGVFKGLANLLVLDLRNNEISWAIEDSNEVFAGLSRLHTLILQGNKIKSITMKAFTGLDSL 395

  Fly   260 HGLELAR---------------------NTWN--CSCSLRPLRAWMLQQNIPSGIPPTCESPPRL 301
            ..|:|:.                     ||.|  |.|.|:....|:........:..:|..|..|
Frog   396 QHLDLSNNAILSVQENGFSFMKLQELILNTSNLLCDCQLKWFPHWLNDNGFHQFVNVSCAHPNWL 460

  Fly   302 SGRAWDKLDVDDFAC----VPQIVATDTTAHGVEGRNITMSC----------------------- 339
            :||:...:|.:||.|    .|||.....|...::|.|::::|
Frog   461 AGRSPLSVDAEDFICDNFPKPQIKLQPETTVALKGMNVSLTCAAASSSDTPMSTAWRKDGEVLYD 525

  Fly   340 ------------------YV--------------------------------------------- 341
                              |:
Frog   526 AEVENFARYHKHGIELIEYITVLHLFNVNFTDEGKYQCVITNHFGSNYSSKAKLTVNEMPSFLKT 590

  Fly   342 ------------------EGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVN 388
                              ||.|.|.:.|        ....|.|..:..|.|.....:....::||
Frog   591 PMDLTIRTGAMARLECAAEGHPPPQIAW--------QKDGGTDFPAARERRMHVMPEDEVLFIVN 647

  Fly   389 MLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSRRPP-EAPWGVRIILLGAVAALLL 452
            :            .::|.|:|:|.|:|.||.:.|:|||.|...|. ..|...|.:..|..|.|..
Frog   648 V------------KIEDMGLYSCTAQNAAGSISANVTLTVLETPSFVRPLEDRTVARGETAVLHC 700

  Fly   453 VGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLF 517
            :.|.|.|                   |.:..::....:::|
Frog   701 IAGGSPA-------------------PRLNWTKDDGPLQVT------------------------ 722

  Fly   518 HDAEEQGYLRAAHTPL-----NDNDAGQAAAIVNPSAGSAQRRNGDYLHV--STHCDDE-----E 570
                |:.:..||:..|     ...|||:....::.:.|:  .|....|||  |.:||..     |
Frog   723 ----ERHFFAAANQLLIIVDAGPEDAGKYTCSMSNTLGT--ERGHINLHVLSSPNCDSSQNIGYE 781

  Fly   571 EDQ------------------------QLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASG 611
            ||.                        .::|                    .|:.|:.:.::
Frog   782 EDGWTTVGIVIIVVVCCVVGTSLVWVIVIYH--------------------MRRKSEDYSIT--- 823

  Fly   612 ANNSAPLEETDLHIPRLIDIGGTDSASSSISSQVDAAARLAGY----AGHTWKTTPIATTKINSP 672
                   ...|:::|  .||      .|.:|||...:....||    ||...:..|.|.   |..
Frog   824 -------NTEDMNLP--ADI------PSYLSSQGTLSEPPEGYSNSEAGSHQQLMPPAN---NCV 870

  Fly   673 HSKP----VTSAAPSSLNTQATPYAHYGNHPADEMATSVFCSEGQESDLFDSNYPDLLDIAKYAV 733
            |...    |.:.:.:.::...||::|.              .:|:...|:.
Frog   871 HKGTDGLYVDTGSEADMDILNTPFSHN--------------MQGKMPHLYS-------------- 907

  Fly   734 AQAQQEGRGQGYAQATTTPNGGLCTLPRKLKTSGKYFRNSSDSQSPLLADNSSKYGSSTLGDGSF 798
                    |.|....|.|..|    ||             ..:.:||:. .|..|.::.:
Frog   908 --------GHGTILPTDTREG----LP-------------IPAAAPLMI-CSDCYDNANI----- 941

  Fly   799 LNEAMGLGRRYSAESSYANYSSTATYTGGGQRANSFLNLVQSGAHQGKLLPSHLGQKPSLPSSPV 863
                      ||....:..|    ||.                ..:.::|||.:.|.|.  .:..
Frog   942 ----------YSRTREFYPY----TYI----------------TEEDQILPSLIAQIPK--ETLY 974

  Fly   864 QHQRSLSSAATPLLDFSALASRAAGAANTSVAAYDYHAAQLERFLEEYRNLQDQLCKMKETCDTI 928
            ||:              .|:.|...|:.||                     .|:|.....:|||.
Frog   975 QHE--------------VLSERDMRASLTS---------------------HDRLDSTNPSCDTF 1004

  Fly   929 R------KKETPLRVAIGQSAAQLADPVMYSAASHSPKPPATSN---LKTKTLLPGQP-PDP 980
            :      |||..|..|.......|:.|:        |..|...|   :||:.:  |.| |.|
Frog  1005 QRPLCGFKKEPGLTAAPHPHFCHLSVPI--------PGKPLLRNEGCIKTEEV--GLPRPSP 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	50/227 (22%)
		leucine-rich repeat	112..137	CDD:275380	7/24 (29%)
		LRR_8	137..196	CDD:290566	17/58 (29%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	24/110 (22%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	12/56 (21%)
		leucine-rich repeat	235..258	CDD:275380	7/39 (18%)
		LRRCT	267..316	CDD:214507	15/50 (30%)
		IG_like	328..428	CDD:214653	27/203 (13%)
		Ig	335..425	CDD:143165	22/193 (11%)
lrig2	XP_002932176.2	PRK15370	<37..>165	CDD:185268	5/21 (24%)
		leucine-rich repeat	37..56	CDD:275380
		leucine-rich repeat	58..81	CDD:275380
		leucine-rich repeat	82..104	CDD:275380
		leucine-rich repeat	105..128	CDD:275378
		LRR	127..>384	CDD:227223	60/247 (24%)
		leucine-rich repeat	129..148	CDD:275380	217/1167 (19%)
		leucine-rich repeat	152..175	CDD:275380	5/32 (16%)
		leucine-rich repeat	176..199	CDD:275380	7/22 (32%)
		leucine-rich repeat	200..223	CDD:275380	7/24 (29%)
		leucine-rich repeat	224..247	CDD:275380	6/22 (27%)
		leucine-rich repeat	248..271	CDD:275380	6/22 (27%)
		leucine-rich repeat	272..295	CDD:275380	7/22 (32%)
		leucine-rich repeat	296..319	CDD:275380	4/22 (18%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..368	CDD:275380	1/23 (4%)
		LRR_8	370..429	CDD:338972	13/58 (22%)
		leucine-rich repeat	371..394	CDD:275380	6/22 (27%)
		leucine-rich repeat	395..417	CDD:275380	3/21 (14%)
		LRRCT	428..476	CDD:214507	12/47 (26%)
		Ig	485..581	CDD:386229	5/95 (5%)
		Ig_1	602..676	CDD:143240	23/93 (25%)
		I-set	679..766	CDD:369462	21/135 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910