DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and lrrtm4

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_031755133.1	Gene:	lrrtm4 / 100485215	XenbaseID:	XB-GENE-949702	Length:	622	Species:	Xenopus tropicalis

Alignment Length:	350	Identity:	90/350 - (25%)
Similarity:	131/350 - (37%)	Gaps:	93/350 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLI 125
            |||..|.....:|..:. ||..|.|..|    .|.|.:.....|||.:..|:|.|.|..|.|:::
Frog    17 LLLPALIVVMVVGAQKT-CPKNCRCDGK----IVYCESHAFRDIPQNISGGSQGLSLRYNSIKML 76

  Fly   126 PDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELR 190
            ....|  :.|..|..:||...::..::..||:.:..|.||.||.|.:|.:.:...:.|..||.|.
Frog    77 KSHQF--SGLNQLVWLYLDHNYISTVDEDAFQGIRRLKELILSSNKISYLGNSTFHPVPNLRNLD 139

  Fly   191 LSGNPILRVPDDAFGHVPQLVKLEL-------------SDC-----------RLSHIAVRAFAGL 231
            ||.|.:..:..:.|..:.:|:.|.|             .||           ||..::..|||||
Frog   140 LSYNKLQTLQSEQFKGLRKLLILHLRSNSLKTVPVRVFQDCRNLDFLDLGYNRLRSLSRNAFAGL 204

  Fly   232 ESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARN---------TWNCSCSLRPLRAWMLQQNI 287
             ..|:.|.|:.|:.|:|.......|.:|..|.|..|         ||          .|...||:
Frog   205 -LKLKELHLEHNQFSKVNFAHFPRLFNLRSLYLQWNKIRSISQGLTW----------TWSALQNL 258

  Fly   288 PSGIPPTCESPPRLSGRAWDKLDVDDFACVPQI------------VATDTTAHGVEGRNITMS-- 338
            .            |||.....|:...|.|:|.:            |..:|....:...:||:|
Frog   259 D------------LSGNDIQNLEPGTFQCLPNLQKLNLDSNKLTNVTQETLNAWISLTSITLSGN 311

  Fly   339 --------CYVEGVPQPAVKWLLKN 355
                    |       |.|.| |||
Frog   312 IWECTKKIC-------PLVFW-LKN 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	50/180 (28%)
		leucine-rich repeat	112..137	CDD:275380	7/24 (29%)
		LRR_8	137..196	CDD:290566	19/58 (33%)
		leucine-rich repeat	138..161	CDD:275380	5/22 (23%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	23/84 (27%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	12/47 (26%)
		leucine-rich repeat	235..258	CDD:275380	7/22 (32%)
		LRRCT	267..316	CDD:214507	11/57 (19%)
		IG_like	328..428	CDD:214653	9/37 (24%)
		Ig	335..425	CDD:143165	9/30 (30%)
lrrtm4	XP_031755133.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910