DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and flrt3

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001116922.1	Gene:	flrt3 / 100144692	XenbaseID:	XB-GENE-490901	Length:	648	Species:	Xenopus tropicalis

Alignment Length:	570	Identity:	124/570 - (21%)
Similarity:	188/570 - (32%)	Gaps:	206/570 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 CPAVCECKWKSGKESVLCLNANLTHIPQ--PLDAGTQLLDLSGNEIQL--IPDDSFATAQLLNLQ 139
            ||:||.|  ..|  .:.|.:.:||.||.  |.||.|  |.|..|:|..  ||.|   ...|..::
Frog    31 CPSVCRC--DGG--FIYCNDRDLTSIPSGIPDDATT--LYLQNNQINNAGIPSD---LRGLDKVE 86

  Fly   140 KVYLAR----------------CHLR-------------------------------LIERHAFR 157
            ::||.|                .||:                               .||..|||
Frog    87 RIYLYRNSLDEFPINLPKNVKELHLQENNIRTITYDALSQIPSIEELHLDDNSVSAVSIEDGAFR 151

  Fly   158 KLINLVELDLSQNLLSAIP---------------------SLALYHVSELRELRLSGN------- 194
            ..|.|..|.||:|.||.||                     .::|..::.|:.|.|.||
Frog   152 DNIFLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTIAEISLQDLTNLKRLVLDGNLLNNNGL 216

  Fly   195 -----------------------PILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLE 236
                                   |...:|.      ..|.||.|.:..::::...|||.| :.|.
Frog   217 GERVFMNLINLTELSLVRNSLTSPPANLPG------TNLRKLYLQENHMNYVPPNAFADL-TQLY 274

  Fly   237 WLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPP---TCESP 298
            .|.:..|.::.:..|....|.:|..|.|..|.|.|.|.::.:|.|:  |::||.:..   .|::|
Frog   275 RLDMSNNNITALPQGIFDDLDNLTQLFLRNNPWYCGCKMKWVRDWL--QSLPSKVNVRGLMCQAP 337

  Fly   299 PRLSGRAWDKLDVDDFACVPQI----VATDTT-------AHG----------------------- 329
            .|:.|.....|:.:.|.|..:|    :...||       |.|
Frog   338 ERVRGMTIKDLNKELFDCKDRIGSNTIHVTTTVLNSLLPAQGQWPVPVTKQPEIRPPDINKIFRT 402

  Fly   330 ----------VEGRNITM-SCYVE---GVPQPAVK--WLLKNRLIANLSAGGDGDSDSEPRTAAA 378
                      ::.::||. :.|:.   .:|..|::  |.|           |.............
Frog   403 TPIPVKKIITIQVKSITTETIYISWKVALPMTALRLSWQL-----------GHSPVFGSITETIV 456

  Fly   379 TQGRKTYVVNMLRNASNLTILTADMQDAGIY------TCAAENKAGKVEASVTLAVSRRPPEAPW 437
            |..|..|::..|...|...|....|:...||      .|.....|.....:.|..::|...:.|:
Frog   457 TGDRTEYLLTALEPESPYRICMVPMETGNIYLSDETPVCIETETAPLKMYNPTTTLNREQEKEPY 521

  Fly   438 -----GVRIILLGAVAALLLV-----------GGSSFAAICLCSLQRRRK 471
                 .:..|:.||||.:.:.           .||.|:..|..|..||||
Frog   522 KNSSLPLAAIIGGAVALVAITLLALVCWYVHRNGSLFSRNCAYSKGRRRK 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	54/256 (21%)
		leucine-rich repeat	112..137	CDD:275380	9/26 (35%)
		LRR_8	137..196	CDD:290566	26/156 (17%)
		leucine-rich repeat	138..161	CDD:275380	10/69 (14%)
		leucine-rich repeat	162..185	CDD:275380	10/43 (23%)
		LRR_8	184..245	CDD:290566	18/90 (20%)
		leucine-rich repeat	186..209	CDD:275380	7/52 (13%)
		leucine-rich repeat	210..234	CDD:275380	8/23 (35%)
		leucine-rich repeat	235..258	CDD:275380	5/22 (23%)
		LRRCT	267..316	CDD:214507	15/51 (29%)
		IG_like	328..428	CDD:214653	21/144 (15%)
		Ig	335..425	CDD:143165	19/101 (19%)
flrt3	NP_001116922.1	PRK15370	<44..>305	CDD:185268	61/272 (22%)
		LRR 1. /evidence=ECO:0000255	58..82		10/28 (36%)
		leucine-rich repeat	61..84	CDD:275380	9/27 (33%)
		LRR 2. /evidence=ECO:0000255	83..105		3/21 (14%)
		leucine-rich repeat	85..105	CDD:275380	3/19 (16%)
		leucine-rich repeat	106..129	CDD:275380	2/22 (9%)
		LRR 3. /evidence=ECO:0000255	107..126		2/18 (11%)
		LRR 4. /evidence=ECO:0000255	127..152		4/24 (17%)
		leucine-rich repeat	130..155	CDD:275380	5/24 (21%)
		LRR 5. /evidence=ECO:0000255	154..179		10/24 (42%)
		leucine-rich repeat	156..176	CDD:275380	9/19 (47%)
		leucine-rich repeat	177..200	CDD:275380	1/22 (5%)
		LRR 6. /evidence=ECO:0000255	181..197		1/15 (7%)
		LRR 7. /evidence=ECO:0000255	198..223		5/24 (21%)
		leucine-rich repeat	201..226	CDD:275380	5/24 (21%)
		LRR 8. /evidence=ECO:0000255	225..246		1/20 (5%)
		leucine-rich repeat	227..248	CDD:275380	2/26 (8%)
		LRR 9. /evidence=ECO:0000255	247..269		6/21 (29%)
		leucine-rich repeat	249..272	CDD:275380	8/23 (35%)
		LRR 10. /evidence=ECO:0000255	270..293		5/23 (22%)
		leucine-rich repeat	273..296	CDD:275380	5/22 (23%)
		PCC	277..>354	CDD:188093	20/78 (26%)
		FN3	413..476	CDD:214495	13/73 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910