DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and elfn1b

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_001920383.1	Gene:	elfn1b / 100144401	ZFINID:	ZDB-GENE-080327-21	Length:	814	Species:	Danio rerio

Alignment Length:	889	Identity:	175/889 - (19%)
Similarity:	303/889 - (34%)	Gaps:	264/889 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PPLRPRLPLHLHLLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQ 113
            ||.. .:|:|::         |.:..||..     |.|.:|...|.|....|||:
Zfish    66 PPYE-NIPMHIN---------STIVDLRLN-----ENKIRSIHFSSLSRFGNLTY---------- 105

  Fly   114 LLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSL 178
             |:|:.|:|..|.|.:| :|| .|||.:.:           .|.|:.||.|     .:|..:
Zfish   106 -LNLTKNDISYIEDGAF-SAQ-FNLQVLQI-----------GFNKMRNLTE-----GMLRGL--- 148

  Fly   179 ALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGN 243
                 ..|:.|.|..|.|..|..:||...|.:..::||                         .|
Zfish   149 -----GRLQYLYLQANLIETVTANAFWECPAIENIDLS-------------------------MN 183

  Fly   244 RLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDK 308
            |:.::...|...|:.|...||..|.::|||.|.....|::.....:.....|::|...||  :..
Zfish   184 RIQQLDGATFRGLSKLTTCELYANPFSCSCELLGFLRWLVAFPNRTSERMACDTPAGFSG--YSL 246

  Fly   309 LDVDDFACVPQIVATDTTAHGVEG----RNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDG-- 367
            |..:     |::.......|.:..    .|:|.  |:.|.|...:...|.:.....|.....|
Zfish   247 LSQN-----PRMPRYRNAFHALSSVCTDDNVTP--YLHGSPDGGIPTRLPDLSPCGLDDCSSGTF 304

  Fly   368 ------------DSDSEP--------RTAAA------TQGRKTYVVNMLRNA--SNLTILTADMQ 404
                        |||:.|        .|:|.      ...||.|::.:..|:  :::..|.:..:
Zfish   305 PEETISISPTFLDSDARPIMKLKEVTHTSAVITIQIPNPFRKMYILVLYNNSFFTDIQNLKSQRE 369

  Fly   405 DAGI--------YT-CAA--ENKAGKVEASVTLAVSRRPPEAPWGVRII-----------LLGAV 447
            :..:        || |.|  .|........:|::...|..:.    |::           :||.:
Zfish   370 EIELQNLKSHTNYTYCVASIRNSLRFNHTCLTISTGPRTLQE----RVVNDSTATHYIMTILGCL 430

  Fly   448 AALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEK--IEMTARTRPDLGGGASCGGGS 510
            ..:|:|.|     :.:..|::|:|    ...|..::.|..::  |||...|..:.|..:......
Zfish   431 FGMLIVLG-----VVVHCLRKRKK----QDEPKSKKLEKMKRNLIEMKYGTELEQGTISQLSQKQ 486

  Fly   511 ATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAAAIVNPSAGSAQRRNGDYLHVSTHCDDEEEDQQL 575
            ...||  ...:...||.||    :|.|..:...|    :|:.:...|:|:.|.:
Zfish   487 ILSAG--ETVQRMPYLPAA----SDTDQYKMQEI----SGTPKTTKGNYMEVRS----------- 530

  Fly   576 HHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASGANNSAPLEETDLHIPRLIDIGGTDSASSS 640
                 :||                        ..|....|.|..||.         .|:.:..|:
Zfish   531 -----EQP------------------------ERSIRECSVPPSETS---------QGSVAEIST 557

  Fly   641 ISSQVDAAARLAGYAGHTWKTTPIATTKINSPHSKPVTSAAPSSLNTQATPYAHYGNHPADEMAT 705
            |:.:||...::........|:.   :|...:..|..|::|.|.        ......||..:
Zfish   558 IAKEVDKVNQIINNCIDALKSD---STSFQTAKSGAVSTAEPQ--------LVLISEHPPGK--- 608

  Fly   706 SVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPNGGLCTLPRKLKTSGKYF 770
                 .|..|.::...|...|.  ::....|.|:       :|:|:.:|.|.: ||..::.|.|
Zfish   609 -----SGFLSPVYKGGYHHPLQ--RHHSMDAPQK-------RASTSSSGSLRS-PRSFRSEGAY- 657

  Fly   771 RNSSDSQSPLLADNSSKYGSSTLGDGSFLNEAMGLGRRYSAESSYANYSSTATYTGGGQRANSFL 835
              .|:|:....|....:.|..|:...:.:..|.....|..:|..:       :|.|......|
Zfish   658 --RSESKYIEKASPQDESGIITVTPAAAILRAEAERIRQYSEHRH-------SYPGPHHIEES-- 711

  Fly   836 NLVQSGAHQGKLLPSHLGQKPSLPS----SPVQHQRSLSSAATP 875
             :..||:.:..:|......:|...|    ||..|  :||..::|
Zfish   712 -IEVSGSRKSSILEPLTRSRPRELSYSQLSPQYH--NLSGYSSP 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	36/156 (23%)
		leucine-rich repeat	112..137	CDD:275380	9/24 (38%)
		LRR_8	137..196	CDD:290566	13/58 (22%)
		leucine-rich repeat	138..161	CDD:275380	4/22 (18%)
		leucine-rich repeat	162..185	CDD:275380	3/22 (14%)
		LRR_8	184..245	CDD:290566	12/60 (20%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	2/23 (9%)
		leucine-rich repeat	235..258	CDD:275380	4/22 (18%)
		LRRCT	267..316	CDD:214507	11/48 (23%)
		IG_like	328..428	CDD:214653	26/144 (18%)
		Ig	335..425	CDD:143165	23/130 (18%)
elfn1b	XP_001920383.1	leucine-rich repeat	82..102	CDD:275378	7/24 (29%)
		LRR_8	102..161	CDD:316378	25/95 (26%)
		leucine-rich repeat	103..126	CDD:275378	11/35 (31%)
		leucine-rich repeat	127..150	CDD:275378	8/46 (17%)
		leucine-rich repeat	151..174	CDD:275378	8/22 (36%)
		leucine-rich repeat	175..188	CDD:275378	4/37 (11%)
		PCC	179..>247	CDD:188093	19/94 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574213
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930