DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and lrrc4b

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001096358.1	Gene:	lrrc4b / 100124949	XenbaseID:	XB-GENE-5945982	Length:	641	Species:	Xenopus tropicalis

Alignment Length:	444	Identity:	131/444 - (29%)
Similarity:	187/444 - (42%)	Gaps:	104/444 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LLLWLLCCCSQLGQLR-AECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQL 124
            ||||:....  ||.:. ..|||.|.|..::.:  |.|....|..:|:.:...|:.|:|..|.||:
Frog    25 LLLWVTSLA--LGGISPTSCPAACTCSNQASR--VACTRRELMEVPESISVNTRYLNLQENIIQV 85

  Fly   125 IPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELREL 189
            |..|:|  ..|.:|:.:.|::..:|.||..||..|.||..|:|..|.|:.:|:.|..::|:||||
Frog    86 IKTDTF--KHLRHLEILQLSKNLIRKIEVGAFNGLPNLSTLELFDNRLTTVPTQAFEYLSKLREL 148

  Fly   190 RLSGNPILRVPDDAFGHVPQLVKLELSDC-RLSHIAVRAFAGLES-------------------- 233
            .|..|||..:|..||..||.|.:|:|.:. :|.:|:..||.||.:
Frog   149 WLRNNPIESIPSYAFNRVPSLRRLDLGELKKLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTAL 213

  Fly   234 -SLEWLKLDGNRLSEVRSGTITSLAS--------------------------------------- 258
             .||.|:|.||||..:|.|:...|.|
Frog   214 VRLEELELSGNRLEMIRPGSFQGLTSLRKLWLMHAHVTIIERNAFDDLKSLEELNLSHNNLMSLP 278

  Fly   259 ------LHGLE---LARNTWNCSCSLRPLRAWMLQQNIPSGIP--PTCESPPRLSGRAWDKLDVD 312
                  ||.||   |..|.|:|:|.:..| :|.|::.:|:...  ..|.|||.|..|...:||..
Frog   279 HDLFTPLHRLERVHLNHNPWHCNCDVLWL-SWWLKETVPNNTTCCARCHSPPNLKMRYIGELDQS 342

  Fly   313 DFAC-VPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTA 376
            .|.| .|.||...|..:..||....:.|.. |....:|.||                   .|...
Frog   343 HFTCYAPVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWL-------------------TPNGT 387

  Fly   377 AATQGRKTYVVNMLRNAS-NLTILTADMQDAGIYTCAAENKAGKVEASVTLAVS 429
            ..|.|.....:::|.:.: |.|.:|  :||.|.|||...|.||...|:.||.||
Frog   388 LMTHGSYRVRISVLHDGTLNFTNVT--VQDTGQYTCMVTNSAGNTTATATLNVS 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	66/226 (29%)
		leucine-rich repeat	112..137	CDD:275380	10/24 (42%)
		LRR_8	137..196	CDD:290566	23/58 (40%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		LRR_8	184..245	CDD:290566	29/82 (35%)
		leucine-rich repeat	186..209	CDD:275380	12/22 (55%)
		leucine-rich repeat	210..234	CDD:275380	9/45 (20%)
		leucine-rich repeat	235..258	CDD:275380	11/22 (50%)
		LRRCT	267..316	CDD:214507	17/50 (34%)
		IG_like	328..428	CDD:214653	26/100 (26%)
		Ig	335..425	CDD:143165	22/90 (24%)
lrrc4b	NP_001096358.1	LRRNT	42..75	CDD:214470	10/34 (29%)
		leucine-rich repeat	73..96	CDD:275380	10/24 (42%)
		leucine-rich repeat	97..120	CDD:275380	8/22 (36%)
		PPP1R42	100..297	CDD:411060	55/196 (28%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		leucine-rich repeat	145..168	CDD:275380	12/22 (55%)
		leucine-rich repeat	169..193	CDD:275380	9/23 (39%)
		leucine-rich repeat	194..215	CDD:275380	0/20 (0%)
		leucine-rich repeat	216..239	CDD:275380	11/22 (50%)
		leucine-rich repeat	240..263	CDD:275380	0/22 (0%)
		leucine-rich repeat	264..285	CDD:275380	0/20 (0%)
		LRRCT	296..346	CDD:214507	17/50 (34%)
		I-set	349..438	CDD:400151	30/110 (27%)
		Ig strand A	349..352	CDD:409353	1/2 (50%)
		Ig strand A'	356..359	CDD:409353	1/2 (50%)
		Ig strand B	365..372	CDD:409353	1/6 (17%)
		Ig strand C	378..383	CDD:409353	3/23 (13%)
		Ig strand C'	386..388	CDD:409353	0/1 (0%)
		Ig strand D	397..401	CDD:409353	0/3 (0%)
		Ig strand E	404..408	CDD:409353	0/3 (0%)
		Ig strand F	418..425	CDD:409353	3/6 (50%)
		Ig strand G	428..438	CDD:409353	4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49155
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910