DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and lingo1

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001093719.1	Gene:	lingo1 / 100101739	XenbaseID:	XB-GENE-921957	Length:	606	Species:	Xenopus tropicalis

Alignment Length:	615	Identity:	128/615 - (20%)
Similarity:	189/615 - (30%)	Gaps:	258/615 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 CCC--------SQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQ 123
            |.|        |.|....:.||..|:|..:.  .||||.......:|:.:...|:|||||.|.|:
Frog     8 CLCPILLIVVGSILSGSASGCPQRCDCSPQD--RSVLCHRKRYLDVPEGIPTDTRLLDLSKNRIK 70

  Fly   124 LIPDDSF----------------------ATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELD 166
            .:..|.|                      |...|.||:.:.|....|:||....|..|.||.:||
Frog    71 ALNQDEFSAFPYLEELELNENIVSIIEPGAFNGLFNLRSLGLRSNRLKLIPLGVFTGLSNLTQLD 135

  Fly   167 LSQNL------------------------------------------------------------ 171
            :|:|.
Frog   136 ISENKIVILLDDMFQDLYNLKSLEVGDNDLVYISHRAFRGLNSLEELTLEKCNLTSVPTEALSHL 200

  Fly   172 ------------------------------------------------------------LSAIP 176
                                                                        ||:||
Frog   201 HGLITLKLRYLNINVIRDYSFKRLYRLKNLEIAHWPYLDTMTSNGLYGLNLTSLSITHSNLSSIP 265

  Fly   177 SLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLD 241
            .:|:.|:..||.|.||.|||..|.......:.:|.:..|...:||.:...||.|| :.|:.|.:.
Frog   266 YVAIRHLVYLRFLNLSYNPITAVEGSMLYELLRLQEFHLVGGQLSVVEPYAFRGL-NHLKVLNVS 329

  Fly   242 GNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPL--RAWML----QQNIPSGIPPTCESPPR 300
            .|.||.:...:..|:.:|..|.|.:|...|.|.|..:  |.|.|    ||       |:|.||..
Frog   330 SNYLSTLEESSFHSVGNLETLILDKNPLACDCRLLWIFRRRWRLNFSRQQ-------PSCSSPEY 387

  Fly   301 LSGRAW----DKLDVDDFAC--------VPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLL 353
            :.|:.:    |.|..:.|.|        ..|:|..|      ||..:...|..:|.|.|.:.|
Frog   388 VQGKEFKDFPDVLQPNYFTCRRARIQDHSAQVVYVD------EGHTVHFFCRADGDPPPTILW-- 444

  Fly   354 KNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILT--------ADMQDAGIYT 410
                             ..|        |||::.:  ::...||:..        |.:||.|.|.
Frog   445 -----------------QSP--------RKTFITS--KSNGRLTVFPDGTLEVRYAQVQDNGTYH 482

  Fly   411 CAAENKAGKVEASVTLAV------------------SRRPPEA-----------PWGVRIILLGA 446
            |.|.|..|...:...|.|                  |.:|.|:           |:.::.:::..
Frog   483 CIASNAGGNDTSLAHLHVRSYSPNWPHKPNKTFAFMSNQPNESDVNSTRASVPFPFDIKTLIIAT 547

  Fly   447 VAALLLVGGSSFAAICLCSLQRRRKLRLWN 476
            .     :|..||..:.|..|.   .|.||:
Frog   548 T-----MGFISFLGVVLFCLV---LLFLWS 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	58/298 (19%)
		leucine-rich repeat	112..137	CDD:275380	12/46 (26%)
		LRR_8	137..196	CDD:290566	26/178 (15%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		leucine-rich repeat	162..185	CDD:275380	11/142 (8%)
		LRR_8	184..245	CDD:290566	20/60 (33%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..234	CDD:275380	8/23 (35%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	17/58 (29%)
		IG_like	328..428	CDD:214653	23/107 (21%)
		Ig	335..425	CDD:143165	20/97 (21%)
lingo1	NP_001093719.1	LRRNT	27..61	CDD:214470	10/35 (29%)
		LRR 1	58..79		10/20 (50%)
		leucine-rich repeat	59..82	CDD:275380	10/22 (45%)
		PLN00113	62..>381	CDD:215061	65/326 (20%)
		LRR 2	82..103		1/20 (5%)
		leucine-rich repeat	83..106	CDD:275380	2/22 (9%)
		LRR_8	106..165	CDD:338972	14/58 (24%)
		LRR 3	106..127		7/20 (35%)
		leucine-rich repeat	107..130	CDD:275380	7/22 (32%)
		LRR 4	130..151		6/20 (30%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		LRR 5	154..175		0/20 (0%)
		leucine-rich repeat	155..178	CDD:275380	0/22 (0%)
		LRR 6	178..199		0/20 (0%)
		leucine-rich repeat	179..250	CDD:275380	0/70 (0%)
		LRR 7	202..223		0/20 (0%)
		leucine-rich repeat	203..226	CDD:275380	0/22 (0%)
		LRR 8	250..271		5/20 (25%)
		leucine-rich repeat	251..274	CDD:275380	6/22 (27%)
		LRR 9	274..295		9/20 (45%)
		leucine-rich repeat	275..298	CDD:275380	9/22 (41%)
		LRR 10	298..319		6/20 (30%)
		leucine-rich repeat	299..322	CDD:275380	8/23 (35%)
		LRR 11	322..343		5/20 (25%)
		leucine-rich repeat	323..343	CDD:275380	5/19 (26%)
		Ig	425..500	CDD:386229	22/103 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910