DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lace and LCB1

DIOPT Version :9

Sequence 1:	NP_001285957.1	Gene:	lace / 34910	FlyBaseID:	FBgn0002524	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_014025.1	Gene:	LCB1 / 855342	SGDID:	S000004911	Length:	558	Species:	Saccharomyces cerevisiae

Alignment Length:	538	Identity:	115/538 - (21%)
Similarity:	219/538 - (40%)	Gaps:	92/538 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 LEHFQKTSFEEVPLHTACLT---YLGFYLLMILGYINQLLFVP------------KVATEKGRDG 156
            :.|..:...:.:|:....:|   ||.:|..::|..|....|:.            :...|.|...
Yeast     1 MAHIPEVLPKSIPIPAFIVTTSSYLWYYFNLVLTQIPGGQFIVSYIKKSHHDDPYRTTVEIGLIL 65

  Fly   157 YVALYDAFESFYSRYVYRRIKDCWNRPICSVPGDELTLKD---------RVTDDYGWSFKFTGTE 212
            |..:|     :.|:...::.... .:|..|....:..::|         ..||:..|....|...
Yeast    66 YGIIY-----YLSKPQQKKSLQA-QKPNLSPQEIDALIEDWEPEPLVDPSATDEQSWRVAKTPVT 124

  Fly   213 --------------------TRCLNLGSYNYLGFAAATGQCADDSEESARSSGLAYCSSRCELGD 257
                                |...||.|.|:|.. :||....:..:.:.::.|:..|......|:
Yeast   125 MEMPIQNHITITRNNLQEKYTNVFNLASNNFLQL-SATEPVKEVVKTTIKNYGVGACGPAGFYGN 188

  Fly   258 NEQLQELEALTARYFGVEDAIVFGMGFATNALNLPSLLGPNSLVISDEKNHASIILGLRLSGATT 322
            .:....||...|::||.:.::::|..|......||:......::::|::....:...|:||.:|.
Yeast   189 QDVHYTLEYDLAQFFGTQGSVLYGQDFCAAPSVLPAFTKRGDVIVADDQVSLPVQNALQLSRSTV 253

  Fly   323 KVFKHNNMRDLERVLRQGVCYGNPKKGGQPWDKV------MILVEGIFSMEGSIVRLPEVIALKK 381
            ..|.||:|..||       |..|.....:..:|:      .|:.||||...|.:..|||:..||.
Yeast   254 YYFNHNDMNSLE-------CLLNELTEQEKLEKLPAIPRKFIVTEGIFHNSGDLAPLPELTKLKN 311

  Fly   382 KYKAYLYLDEAHSVGAMGSRGRGVTDYFNVD-PKEVDILMGTFTKSFGSAGGYLAGSKKLIDFLR 445
            |||..|::||..|:|.:|:.|||::::||:| ...:||.:|:...:.||.||::.|...:....|
Yeast   312 KYKFRLFVDETFSIGVLGATGRGLSEHFNMDRATAIDITVGSMATALGSTGGFVLGDSVMCLHQR 376

  Fly   446 TNSHAHCYAASISPPIAQQILTSMKTIMGEDGTDIGRKKIHQLARNTRYFRRRLAQLGVITYGHE 510
            ..|:|:|::|.:.   |..:.:..|.:...|..:...:.:.:|:::..           .::..:
Yeast   377 IGSNAYCFSACLP---AYTVTSVSKVLKLMDSNNDAVQTLQKLSKSLH-----------DSFASD 427

  Fly   511 DSPVVPMLVYLFSKIGAVVRTLTTRHIAAVGAGFPATPIMEGRIRFCLSAAHTKEQLDFALEAID 575
            || :...::...|.:.||:....|....:...|:....:.|     .:||...|.|.:..:|..:
Yeast   428 DS-LRSYVIVTSSPVSAVLHLQLTPAYRSRKFGYTCEQLFE-----TMSALQKKSQTNKFIEPYE 486

  Fly   576 E-------IADDLGLKYS 586
            |       |.|...:.|:
Yeast   487 EEEKFLQSIVDHALINYN 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lace	NP_001285957.1	PLN02483	117..587	CDD:178101	114/528 (22%)
lace	NP_001285957.1	BioF	164..577	CDD:223234	99/455 (22%)
LCB1	NP_014025.1	AAT_I	62..547	CDD:418510	105/477 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810