DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lace and LCB2

DIOPT Version :9

Sequence 1:	NP_001285957.1	Gene:	lace / 34910	FlyBaseID:	FBgn0002524	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_010347.1	Gene:	LCB2 / 851634	SGDID:	S000002469	Length:	561	Species:	Saccharomyces cerevisiae

Alignment Length:	547	Identity:	229/547 - (41%)
Similarity:	328/547 - (59%)	Gaps:	32/547 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SAPA-YTEIRTRRCQPKPANDAQSPSSINYHPEKKSIPN-GHASILDQESKPNQAEGKLSPELEH 109
            |.|| ||  |...|:|:     :.|..|....|..::.: ||  :...:|:    .||..||
Yeast     2 STPANYT--RVPLCEPE-----ELPDDIQKENEYGTLDSPGH--LYQVKSR----HGKPLPE--- 50

  Fly   110 FQKTSFEEVPLHTACLTYLGFYLLMILGYINQLLFVPKVATEKGR-------DGYVALYDAFESF 167
               ...:..|.:.:.||||.:.:|:|||:::..|   .:..:|.:       ||....:..||||
Yeast    51 ---PVVDTPPYYISLLTYLNYLILIILGHVHDFL---GMTFQKNKHLDLLEHDGLAPWFSNFESF 109

  Fly   168 YSRYVYRRIKDCWNRPICSVPGDELTLKDRVTDDYGWSFKFTGTETRCLNLGSYNYLGFAAATGQ 232
            |.|.:..||.||::||...|||..:...||::.:....|.::|....|:||.||||||||.:.||
Yeast   110 YVRRIKMRIDDCFSRPTTGVPGRFIRCIDRISHNINEYFTYSGAVYPCMNLSSYNYLGFAQSKGQ 174

  Fly   233 CADDSEESARSSGLAYCSSRCELGDNEQLQELEALTARYFGVEDAIVFGMGFATNALNLPSLLGP 297
            |.|.:.||.....:.....|.::|..:...:.|.|.||:.|.|||:||.||:.|||....:.|..
Yeast   175 CTDAALESVDKYSIQSGGPRAQIGTTDLHIKAEKLVARFIGKEDALVFSMGYGTNANLFNAFLDK 239

  Fly   298 NSLVISDEKNHASIILGLRLSGATTKVFKHNNMRDLERVLRQGVCYGNPKKGGQPWDKVMILVEG 362
            ..||||||.||.||..|:|||||..:.|||.:|..||:::|:.:..|.||. .:||.|::|..||
Yeast   240 KCLVISDELNHTSIRTGVRLSGAAVRTFKHGDMVGLEKLIREQIVLGQPKT-NRPWKKILICAEG 303

  Fly   363 IFSMEGSIVRLPEVIALKKKYKAYLYLDEAHSVGAMGSRGRGVTDYFNVDPKEVDILMGTFTKSF 427
            :|||||::..||:::.||||||.||::|||||:||||..||||.:.|.||||:||||||||||||
Yeast   304 LFSMEGTLCNLPKLVELKKKYKCYLFIDEAHSIGAMGPTGRGVCEIFGVDPKDVDILMGTFTKSF 368

  Fly   428 GSAGGYLAGSKKLIDFLRTNSHAHCYAASISPPIAQQILTSMKTIMGEDGTDIGRKKIHQLARNT 492
            |:||||:|..:.:||.||.:.....|:.|:..|:..|.::|::||.||.....|.:::.::|.|:
Yeast   369 GAAGGYIAADQWIIDRLRLDLTTVSYSESMPAPVLAQTISSLQTISGEICPGQGTERLQRIAFNS 433

  Fly   493 RYFRRRLAQLGVITYGHEDSPVVPMLVYLFSKIGAVVRTLTTRHIAAVGAGFPATPIMEGRIRFC 557
            ||.|..|.:||.|.||..||||:|:|:|..||:.|..|.:..|.||.|...:||||::|.|:|||
Yeast   434 RYLRLALQRLGFIVYGVADSPVIPLLLYCPSKMPAFSRMMLQRRIAVVVVAYPATPLIESRVRFC 498

  Fly   558 LSAAHTKEQLDFALEAIDEIADDLGLK 584
            :||:.|||.:|:.|..:.|:.|.|.||
Yeast   499 MSASLTKEDIDYLLRHVSEVGDKLNLK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lace	NP_001285957.1	PLN02483	117..587	CDD:178101	211/475 (44%)
lace	NP_001285957.1	BioF	164..577	CDD:223234	193/412 (47%)
LCB2	NP_010347.1	AAT_I	57..525	CDD:418510	209/471 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343724
Domainoid	1	1.000	348	1.000	Domainoid score	I145
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21610
Inparanoid	1	1.050	411	1.000	Inparanoid score	I302
Isobase	1	0.950	-	0	Normalized mean entropy	S642
OMA	1	1.010	-	-		QHG53569
OrthoFinder	1	1.000	-	-		FOG0001517
OrthoInspector	1	1.000	-	-		oto99052
orthoMCL	1	0.900	-	-		OOG6_100700
Panther	1	1.100	-	-	LDO	PTHR13693
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R652
SonicParanoid	1	1.000	-	-		X956
TreeFam	1	0.960	-	-
	16	15.740