DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lace and sptlc2b

DIOPT Version :9

Sequence 1:	NP_001285957.1	Gene:	lace / 34910	FlyBaseID:	FBgn0002524	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001108213.1	Gene:	sptlc2b / 557286	ZFINID:	ZDB-GENE-080305-8	Length:	558	Species:	Danio rerio

Alignment Length:	535	Identity:	291/535 - (54%)
Similarity:	383/535 - (71%)	Gaps:	30/535 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 EKKSIPNGHAS---ILDQESKPNQAE------------GKLSPELEHFQKTSFEEVPLHTACLTY 127
            :||:..||...   :..|:.....||            .||..|       ||||.||..|.|||
Zfish    17 DKKTCGNGFVKSHCLFQQKRYRRPAEKNHHASCTSLLYNKLFVE-------SFEETPLLVAVLTY 74

  Fly   128 LGFYLLMILGYINQLLFVPK-----VATEK-GRDGYVALYDAFESFYSRYVYRRIKDCWNRPICS 186
            :|:.:|.|.||:...|...|     :|.|: .:..:|.||..||:||:|.:|.||:|.|||||||
Zfish    75 MGYGILTIFGYLRDFLRDWKFEKCHLAREREEQKDFVPLYQDFENFYTRNLYMRIRDNWNRPICS 139

  Fly   187 VPGDELTLKDRVTDDYGWSFKFTGTETR-CLNLGSYNYLGFAAATGQCADDSEESARSSGLAYCS 250
            |||.::.|.:|||.||.|:|:.||...: .:|:|||||||||..:|.|||.:..|....|:...|
Zfish   140 VPGAKMDLVERVTPDYNWTFEHTGKVLKDVINMGSYNYLGFAENSGTCADAAAHSTVKYGVGVSS 204

  Fly   251 SRCELGDNEQLQELEALTARYFGVEDAIVFGMGFATNALNLPSLLGPNSLVISDEKNHASIILGL 315
            :|.|:|:.::.:|||.|.||:.|||.::|||||||||::|:|:|.|...|::|||.||||::||.
Zfish   205 TRQEIGNLDKHEELEKLVARFLGVESSMVFGMGFATNSMNIPALTGKGCLILSDELNHASLVLGA 269

  Fly   316 RLSGATTKVFKHNNMRDLERVLRQGVCYGNPKKGGQPWDKVMILVEGIFSMEGSIVRLPEVIALK 380
            ||||:|.:|||||||:.||::||..:.:|.|:. .:||.|::|:||||:||||||||||||||||
Zfish   270 RLSGSTIRVFKHNNMQSLEKMLRDAIVHGQPRT-HRPWKKILIVVEGIYSMEGSIVRLPEVIALK 333

  Fly   381 KKYKAYLYLDEAHSVGAMGSRGRGVTDYFNVDPKEVDILMGTFTKSFGSAGGYLAGSKKLIDFLR 445
            ||||||||||||||:||:|:|||||.|||.:||.:|||:|||||||||:||||:.|.|:|||:||
Zfish   334 KKYKAYLYLDEAHSIGALGTRGRGVVDYFGLDPSDVDIMMGTFTKSFGAAGGYIGGKKELIDYLR 398

  Fly   446 TNSHAHCYAASISPPIAQQILTSMKTIMGEDGTDIGRKKIHQLARNTRYFRRRLAQLGVITYGHE 510
            .:||:..||.|:||||.|||:||||.|||:|||.:|::::.||:.||.||||||.::|.|.||:.
Zfish   399 LHSHSAVYATSMSPPITQQIITSMKCIMGKDGTTLGQERLRQLSENTTYFRRRLHEMGFIIYGNN 463

  Fly   511 DSPVVPMLVYLFSKIGAVVRTLTTRHIAAVGAGFPATPIMEGRIRFCLSAAHTKEQLDFALEAID 575
            ||||||:::|:.:||||..|.:..|:|..|..|||||||:|.|.|||:|||||:|.||.||.||.
Zfish   464 DSPVVPLMLYMPAKIGAFGREMLKRNIGTVVVGFPATPIIESRARFCVSAAHTREMLDTALNAIS 528

  Fly   576 EIADDLGLKYSRKPR 590
            |:.|.|.||||||.|
Zfish   529 EVGDLLQLKYSRKYR 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lace	NP_001285957.1	PLN02483	117..587	CDD:178101	274/476 (58%)
lace	NP_001285957.1	BioF	164..577	CDD:223234	249/413 (60%)
sptlc2b	NP_001108213.1	PLN02483	66..540	CDD:178101	273/474 (58%)
sptlc2b	NP_001108213.1	BioF	116..531	CDD:223234	250/415 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	463	1.000	Domainoid score	I453
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	569	1.000	Inparanoid score	I1031
OMA	1	1.010	-	-		QHG53569
OrthoDB	1	1.010	-	-		D312139at33208
OrthoFinder	1	1.000	-	-		FOG0001517
OrthoInspector	1	1.000	-	-		otm25687
orthoMCL	1	0.900	-	-		OOG6_100700
Panther	1	1.100	-	-	O	PTHR13693
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R652
SonicParanoid	1	1.000	-	-		X956
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870