DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lace and sptlc2a

DIOPT Version :9

Sequence 1:	NP_001285957.1	Gene:	lace / 34910	FlyBaseID:	FBgn0002524	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001018455.1	Gene:	sptlc2a / 553646	ZFINID:	ZDB-GENE-050522-23	Length:	534	Species:	Danio rerio

Alignment Length:	525	Identity:	282/525 - (53%)
Similarity:	374/525 - (71%)	Gaps:	26/525 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 NYHPEKKSIPNGHASILDQESKPNQA-EGKL--SPELEHFQKTSFEEVPLHTACLTYLGFYLLMI 135
            |:|        .|.....||...:.| .|:|  .|.:|     ||||.|:..|.|||:|:.:|.|
Zfish     4 NHH--------HHLQYQKQEKVYHAACNGELYSRPFIE-----SFEETPMLVAVLTYMGYGILTI 55

  Fly   136 LGYINQLLFVPKV-------ATEKGRDGYVALYDAFESFYSRYVYRRIKDCWNRPICSVPGDELT 193
            .||:...:...|:       ..|:.:| :|.||..||:||:|.:|.||:|.||||||||||.:..
Zfish    56 FGYLRDFMREWKIEKCHIAREREEQKD-FVPLYQDFENFYTRNLYMRIRDSWNRPICSVPGAKFD 119

  Fly   194 LKDRVTDDYGWSFKFTGTETR-CLNLGSYNYLGFAAATGQCADDSEESARSSGLAYCSSRCELGD 257
            |.:|.::||.|:|::||...: .:|||||||||||..||.||..:.|.....|:....:|.|:|:
Zfish   120 LVERSSNDYNWTFEYTGRVVKDVINLGSYNYLGFAENTGSCATAAGEVTVKFGVGVAGTRQEMGN 184

  Fly   258 NEQLQELEALTARYFGVEDAIVFGMGFATNALNLPSLLGPNSLVISDEKNHASIILGLRLSGATT 322
            .::.::||.|.|.:..||.|:.||||||||::|:|:|.|...|::|||.||||::||.||||:|.
Zfish   185 LDRHEKLEKLVASFLRVESAMAFGMGFATNSMNIPALAGKGCLILSDELNHASLVLGARLSGSTI 249

  Fly   323 KVFKHNNMRDLERVLRQGVCYGNPKKGGQPWDKVMILVEGIFSMEGSIVRLPEVIALKKKYKAYL 387
            :|||||||:.||::||..:.:|.|:. .:||.|::||||||:||||||:||||||||||||||||
Zfish   250 RVFKHNNMQSLEKLLRDAIVHGQPRT-HRPWKKILILVEGIYSMEGSIIRLPEVIALKKKYKAYL 313

  Fly   388 YLDEAHSVGAMGSRGRGVTDYFNVDPKEVDILMGTFTKSFGSAGGYLAGSKKLIDFLRTNSHAHC 452
            |||||||:||:|..||||.:||.:||::|||:|||||||||:||||:.|.|.|||:|||:||:..
Zfish   314 YLDEAHSIGALGPGGRGVVEYFGLDPRDVDIMMGTFTKSFGAAGGYIGGRKDLIDYLRTHSHSAV 378

  Fly   453 YAASISPPIAQQILTSMKTIMGEDGTDIGRKKIHQLARNTRYFRRRLAQLGVITYGHEDSPVVPM 517
            ||:|:|.|:.:||:||||.|||||||.|||.:|.:||.||.||||||.::|.|.||:.|||||||
Zfish   379 YASSMSAPVVEQIITSMKCIMGEDGTTIGRSRIQRLAENTVYFRRRLREMGFIIYGNNDSPVVPM 443

  Fly   518 LVYLFSKIGAVVRTLTTRHIAAVGAGFPATPIMEGRIRFCLSAAHTKEQLDFALEAIDEIADDLG 582
            ::|:.:||||..|.:..|:|..|..|||||||:|.|.|||:||||:||.||.||:.|.|:.|.|.
Zfish   444 MLYMPAKIGAFGREMLKRNIGVVVVGFPATPIIESRARFCISAAHSKEMLDRALDVISEVGDLLQ 508

  Fly   583 LKYSR 587
            |||||
Zfish   509 LKYSR 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lace	NP_001285957.1	PLN02483	117..587	CDD:178101	267/477 (56%)
lace	NP_001285957.1	BioF	164..577	CDD:223234	244/413 (59%)
sptlc2a	NP_001018455.1	PLN02483	39..515	CDD:178101	268/477 (56%)
sptlc2a	NP_001018455.1	BioF	89..504	CDD:223234	245/415 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	463	1.000	Domainoid score	I453
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21610
Inparanoid	1	1.050	569	1.000	Inparanoid score	I1031
OMA	1	1.010	-	-		QHG53569
OrthoDB	1	1.010	-	-		D312139at33208
OrthoFinder	1	1.000	-	-		FOG0001517
OrthoInspector	1	1.000	-	-		otm25687
orthoMCL	1	0.900	-	-		OOG6_100700
Panther	1	1.100	-	-	LDO	PTHR13693
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R652
SonicParanoid	1	1.000	-	-		X956
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870