DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lace and SPTLC3

DIOPT Version :9

Sequence 1:	NP_001285957.1	Gene:	lace / 34910	FlyBaseID:	FBgn0002524	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001336874.1	Gene:	SPTLC3 / 55304	HGNCID:	16253	Length:	552	Species:	Homo sapiens

Alignment Length:	543	Identity:	271/543 - (49%)
Similarity:	371/543 - (68%)	Gaps:	25/543 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 KPANDAQSPSSINYHPEKKSIPNGHASILDQESKPNQAEGKLSPELEHFQKTSFEEVPLHTACLT 126
            |.:|.:||         :....||......|..||:..: ||..|       ||||.|||....|
Human    19 KQSNGSQS---------RNCTKNGIVKEAQQNGKPHFYD-KLIVE-------SFEEAPLHVMVFT 66

  Fly   127 YLGFYLLMILGYINQLL---FVPK--VATE-KGRDGYVALYDAFESFYSRYVYRRIKDCWNRPIC 185
            |:|:.:..:.||:...|   .:.|  .|.| |.:..:|.||..||:||:|.:|.||:|.||||||
Human    67 YMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYMRIRDNWNRPIC 131

  Fly   186 SVPGDELTLKDRVTDDYGWSFKFTGTETR-CLNLGSYNYLGFAAATGQCADDSEESARSSGLAYC 249
            |.||....|.:||:|||.|:|:|||...: .:|:||||:||.||...:.....::.....|....
Human   132 SAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTGVA 196

  Fly   250 SSRCELGDNEQLQELEALTARYFGVEDAIVFGMGFATNALNLPSLLGPNSLVISDEKNHASIILG 314
            |:|.|:|..::.:|||.|.|::..||.|:|||||||||::|:|:|:|...|::|||.||.|::||
Human   197 STRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLG 261

  Fly   315 LRLSGATTKVFKHNNMRDLERVLRQGVCYGNPKKGGQPWDKVMILVEGIFSMEGSIVRLPEVIAL 379
            .||||||.::|||||.:.||::||..|.||.|:. .:.|.|::|||||::|||||||.||::|||
Human   262 ARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRT-RRAWKKILILVEGVYSMEGSIVHLPQIIAL 325

  Fly   380 KKKYKAYLYLDEAHSVGAMGSRGRGVTDYFNVDPKEVDILMGTFTKSFGSAGGYLAGSKKLIDFL 444
            |||||||||:|||||:||:|..|||||::|.:||.|||:||||||||||::|||:||.|.|:|:|
Human   326 KKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYL 390

  Fly   445 RTNSHAHCYAASISPPIAQQILTSMKTIMGEDGTDIGRKKIHQLARNTRYFRRRLAQLGVITYGH 509
            |.:||:..||:|:|||||:||:.|:|.|||.|||..|.:::.|||:||||||:||.::|.|.||:
Human   391 RVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGN 455

  Fly   510 EDSPVVPMLVYLFSKIGAVVRTLTTRHIAAVGAGFPATPIMEGRIRFCLSAAHTKEQLDFALEAI 574
            |::.|||:|:|:..|:.|..|.:..:.|..|..||||||:.|.|.|||:|||||:|.||..|||:
Human   456 ENASVVPLLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEAL 520

  Fly   575 DEIADDLGLKYSRKPRDPNPVIY 597
            ||:.|.|.|||||..:...|.:|
Human   521 DEMGDLLQLKYSRHKKSARPELY 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lace	NP_001285957.1	PLN02483	117..587	CDD:178101	252/476 (53%)
lace	NP_001285957.1	BioF	164..577	CDD:223234	229/413 (55%)
SPTLC3	NP_001336874.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		4/18 (22%)
SPTLC3	NP_001336874.1	PLN02483	57..549	CDD:178101	256/488 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	465	1.000	Domainoid score	I470
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	570	1.000	Inparanoid score	I1060
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53569
OrthoDB	1	1.010	-	-		D312139at33208
OrthoFinder	1	1.000	-	-		FOG0001517
OrthoInspector	1	1.000	-	-		otm40430
orthoMCL	1	0.900	-	-		OOG6_100700
Panther	1	1.100	-	-	O	PTHR13693
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X956
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840