DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lace and alas2

DIOPT Version :9

Sequence 1:	NP_001285957.1	Gene:	lace / 34910	FlyBaseID:	FBgn0002524	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001006926.1	Gene:	alas2 / 448773	XenbaseID:	XB-GENE-487573	Length:	608	Species:	Xenopus tropicalis

Alignment Length:	468	Identity:	125/468 - (26%)
Similarity:	210/468 - (44%)	Gaps:	79/468 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 VPKVATEKGRDGYVALYDAFESFYSR--------YVYRRIKDCWNRPICSVPGDELTLKDRVTDD 201
            :|....::...|..|.  .::.|:||        :.||..|....|      .|.....:..:|.
Frog   149 IPTHLIKENMTGRAAF--GYDDFFSRRIEEKKSDHTYRLFKTVNRR------ADAYPFAEDYSDL 205

  Fly   202 YG-------WSFKFTGTETRCLNLGSYNYLGFA---AATGQCADDSEESARSSGLAYCSSRCELG 256
            :|       |          |.|    :|||.:   ......|:..||....:|    .:|...|
Frog   206 HGEKKEVSVW----------CSN----DYLGMSRHPKVLKAIAEALEEHGAGAG----GTRNISG 252

  Fly   257 DNEQLQELEALTARYFGVEDAIVFGMGFATNALNLPSL--LGPNSLVISDEKNHASIILGLRLSG 319
            .::...:||...|.....:.|::|...|..|...|.:|  :.|...:.||..||||:|.|:|.||
Frog   253 TSKYHVDLECELADLHNKDAALLFSSCFVANDSTLFTLAKMLPGCEIYSDAGNHASMIQGIRNSG 317

  Fly   320 ATTKVFKHNNMRDLERVLRQGVCYGNPKKGGQPWDKVMILVEGIFSMEGSIVRLPEVIALKKKYK 384
            .|..||:||:...||.:|::    .|||      ...::..|.:.||:|:|..|.||..:..||.
Frog   318 VTKFVFRHNDPAHLEELLQK----ANPK------TPKIVAFETVHSMDGAICPLEEVCDIAHKYG 372

  Fly   385 AYLYLDEAHSVGAMGSRGRGVTDYFNVDPKEVDILMGTFTKSFGSAGGYLAGSKKLIDFLRTNSH 449
            |..::||.|:||..|:.|.||.:..:|..| :||:.||..|:||..|||:|.:..|||.:|:.:.
Frog   373 ALTFVDEVHAVGLYGTHGAGVGERDSVMHK-MDIISGTLGKAFGCVGGYVASTASLIDTVRSYAA 436

  Fly   450 AHCYAASISPPIAQQILTSMKTIMGEDGTDIGRKKIHQLARNTRYFRRRL--AQLGVITYGHEDS 512
            ...:..|:.|.:....:.|::.:..|:|..:  ::.||  ||.::.|:.|  |.|.||..   .|
Frog   437 GFIFTTSLPPMVLAGAVESVRVLKSEEGQAL--RRAHQ--RNVKHMRQLLMDAGLPVINC---PS 494

  Fly   513 PVVPMLVYLFSKIG-AVVRT------LTTRHIAAVGAGFPATPIMEGRIRFCLSAAHTKEQLDFA 570
            .::|:      ::| |.:.|      |:..:|......:|..|..|..:|...|..||.:.:::.
Frog   495 HIIPI------RVGNAAINTRICDVLLSQYNIYVQAINYPTVPRGEELLRLAPSPHHTPDMMNYF 553

  Fly   571 LEAIDEIADDLGL 583
            :|::.....::|:
Frog   554 VESLVSAWKEVGM 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lace	NP_001285957.1	PLN02483	117..587	CDD:178101	125/468 (27%)
lace	NP_001285957.1	BioF	164..577	CDD:223234	121/441 (27%)
alas2	NP_001006926.1	Preseq_ALAS	2..114	CDD:370250
alas2	NP_001006926.1	AAT_I	164..568	CDD:388495	122/453 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910