DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lace and lcb2

DIOPT Version :9

Sequence 1:	NP_001285957.1	Gene:	lace / 34910	FlyBaseID:	FBgn0002524	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001342802.1	Gene:	lcb2 / 3361415	PomBaseID:	SPAC21E11.08	Length:	603	Species:	Schizosaccharomyces pombe

Alignment Length:	559	Identity:	231/559 - (41%)
Similarity:	327/559 - (58%)	Gaps:	42/559 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 DAQSPSSINYHPEKKSIPNGHASILDQESKPNQAE-GKLSPE--------LEHFQKTSFEEV--P 119
            |..||:||:. .|||.: ..|..:...|:.|...| .||..|        .||..:..|..:  |
pombe     5 DFVSPTSIDV-SEKKEV-EFHKKVDHVENPPLSTESAKLEAEEVAAEKLNSEHLLENEFAPITDP 67

  Fly   120 LHT----------------------ACLTYLGFYLLMILGYINQLLFVPKVATE-----KGRDGY 157
            .|.                      ...|||.:.:|:|:|::.. .|..:...:     |..|||
pombe    68 THRRVSKNPDGAELFQFEDEPSYYYVVATYLTYLVLIIIGHVRD-FFGKRFHKDDYKYLKDNDGY 131

  Fly   158 VALYDAFESFYSRYVYRRIKDCWNRPICSVPGDELTLKDRVTDDYGWSFKFTGTETRCLNLGSYN 222
            ..||:.|::||.|.:..||.||::||...|||..:.|.:|.:.|...:||.||..:..||:.|||
pombe   132 APLYNHFDNFYVRRLQHRINDCFSRPTMGVPGRVIRLMNRYSTDSNSTFKLTGDTSLALNVSSYN 196

  Fly   223 YLGFAAATGQCADDSEESARSSGLAYCSSRCELGDNEQLQELEALTARYFGVEDAIVFGMGFATN 287
            |||||.:.|.||...||:.:..||:.|||....|.....:|:|.|||.:.|...|:||..||:||
pombe   197 YLGFAQSHGPCATKVEEAMQKYGLSTCSSNAICGTYGLHKEVEELTANFVGKPAALVFSQGFSTN 261

  Fly   288 ALNLPSLLGPNSLVISDEKNHASIILGLRLSGATTKVFKHNNMRDLERVLRQGVCYGNPKKGGQP 352
            |....:|:.|.||:||||.||.||..|.|||||..:|:|||:|.|||||||:.:..|.|:. .:|
pombe   262 ATVFSTLMCPGSLIISDELNHTSIRFGARLSGANIRVYKHNDMTDLERVLREVISQGQPRT-HRP 325

  Fly   353 WDKVMILVEGIFSMEGSIVRLPEVIALKKKYKAYLYLDEAHSVGAMGSRGRGVTDYFNVDPKEVD 417
            :.|:::::||::||||:...||:|:.||.:||.||::|||||:||:|.||.|:.|||.:....||
pombe   326 YSKILVVIEGLYSMEGNFCDLPKVVELKNRYKFYLFIDEAHSIGAIGPRGGGICDYFGISTDHVD 390

  Fly   418 ILMGTFTKSFGSAGGYLAGSKKLIDFLRTNSHAHCYAASISPPIAQQILTSMKTIMGEDGTDIGR 482
            |||||||||||:||||::.:..:|:.||..:..:.||.|:||.:..||.:|...||....|..|.
pombe   391 ILMGTFTKSFGAAGGYISATPNIINKLRVTNPGYVYAESMSPAVLAQIKSSFLEIMDNSPTSAGL 455

  Fly   483 KKIHQLARNTRYFRRRLAQLGVITYGHEDSPVVPMLVYLFSKIGAVVRTLTTRHIAAVGAGFPAT 547
            ::|.:||.|:||.|..|.:||.|.:|::||||||:|:|...||.|....:..|.||.|..|:||.
pombe   456 ERIERLAFNSRYIRLGLKRLGFIIFGNDDSPVVPLLLYNPGKINAFSHEMLKRGIAVVVVGYPAC 520

  Fly   548 PIMEGRIRFCLSAAHTKEQLDFALEAIDEIADDLGLKYS 586
            |::..|:|||.||:|.|..:|:.|.|.||:.:.|.||:|
pombe   521 PLLTSRVRFCFSASHNKADMDYFLRACDEVGEKLQLKFS 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lace	NP_001285957.1	PLN02483	117..587	CDD:178101	213/499 (43%)
lace	NP_001285957.1	BioF	164..577	CDD:223234	193/412 (47%)
lcb2	NP_001342802.1	PLN02483	89..565	CDD:178101	211/473 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	343	1.000	Domainoid score	I185
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21610
Inparanoid	1	1.050	414	1.000	Inparanoid score	I357
OMA	1	1.010	-	-		QHG53569
OrthoFinder	1	1.000	-	-		FOG0001517
OrthoInspector	1	1.000	-	-		oto100547
orthoMCL	1	0.900	-	-		OOG6_100700
Panther	1	1.100	-	-	LDO	PTHR13693
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R652
SonicParanoid	1	1.000	-	-		X956
TreeFam	1	0.960	-	-
	14	13.860