Protein Alignment lace and ALAS2

DIOPT Version :9

• Sequence 1: NP_001285957.1
• Gene: lace / 34910
• FlyBaseID: FBgn0002524
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_000023.2
• Gene: ALAS2 / 212
• HGNCID: 397
• Length: 587
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 138/548 - (25%)
• Similarity: 243/548 - (44%)
• Gaps: 79/548 - (14%)

  Fly    58 RCQPKPANDAQSPSSINYH-------PEKKSIPNGH-----ASILDQESKPNQAEGKLSPELEHF 110
            ||   |....|.|:....|       .:..|...||     :.:.|.:||..|   |.:||::..
Human    37 RC---PILATQGPNCSQIHLKATKAGGDSPSWAKGHCPFMLSELQDGKSKIVQ---KAAPEVQED 95

  Fly   111 QKTSFEEVPLHTACLTYLGFY-----LLMILGYINQLLFVPKVATEKGRDG-YVALYDAFESFYS 169
            .|....::|.....::....:     ...|.|.:..|:       :....| ||..||   .|:.
Human    96 VKAFKTDLPSSLVSVSLRKPFSGPQEQEQISGKVTHLI-------QNNMPGNYVFSYD---QFFR 150

  Fly   170 RYVYRRIKDCWNRPICSVPGDELTLKDRVTDDYGWSFKFTGTETRCLNLG---SYNYLGFAAATG 231
            ..:..:.:|...|...:|        :|..|.|.::..|:.......::.   |.:|||.:...
Human   151 DKIMEKKQDHTYRVFKTV--------NRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMSRHP- 206

  Fly   232 QCADDSEESARSSGLAYCSSRCELGDNEQLQELEALTARYFGVEDAIVFGMGFATNALNLPSL-- 294
            |....::|:.:..|.....:|...|.::...|||...|.....:.|::|...|..|...|.:|
Human   207 QVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAK 271

  Fly   295 LGPNSLVISDEKNHASIILGLRLSGATTKVFKHNNMRDLERVLRQGVCYGNPKKGGQPWDKVMIL 359
            :.|...:.||..||||:|.|:|.|||...||:||:...|:::|.:    .|||      ...::.
Human   272 ILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEK----SNPK------IPKIVA 326

  Fly   360 VEGIFSMEGSIVRLPEVIALKKKYKAYLYLDEAHSVGAMGSRGRGVTDYFNVDPKEVDILMGTFT 424
            .|.:.||:|:|..|.|:..:..:|.|..::||.|:||..||||.|:.:...:..| :||:.||..
Human   327 FETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHK-IDIISGTLG 390

  Fly   425 KSFGSAGGYLAGSKKLIDFLRTNSHAHCYAASISPPIAQQILTSMKTIMGEDGTDIGRKKIHQLA 489
            |:||..|||:|.::.|:|.:|:.:....:..|:.|.:....|.|::.:.||:|..:  ::.||
Human   391 KAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQAL--RRAHQ-- 451

  Fly   490 RNTRYFRRRLAQLGVITYGHEDSPVVPMLVYLFS-KIG-AVVRT-----LTTRH-IAAVGAGFPA 546
            ||.::.|:.|...|:        ||:|...::.. ::| |.:.:     |.::| |......:|.
Human   452 RNVKHMRQLLMDRGL--------PVIPCPSHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPT 508

  Fly   547 TPIMEGRIRFCLSAAHTKEQLDFALEAI 574
            .|..|..:|...|..|:.:.::..:|.:
Human   509 VPRGEELLRLAPSPHHSPQMMEDFVEKL 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lace	NP_001285957.1	PLN02483	117..587	CDD:178101	121/477 (25%)
		BioF	164..577	CDD:223234	112/424 (26%)
ALAS2	NP_000023.2	Preseq_ALAS	5..100	CDD:286162	17/68 (25%)
		5aminolev_synth	143..548	CDD:273820	114/429 (27%)
		BioF	143..534	CDD:223234	113/425 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910