Protein Alignment lace and Alas1

DIOPT Version :9

• Sequence 1: NP_001285957.1
• Gene: lace / 34910
• FlyBaseID: FBgn0002524
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001278764.1
• Gene: Alas1 / 11655
• MGIID: 87989
• Length: 642
• Species: Mus musculus
• Alignment Length: 593
• Identity: 153/593 - (25%)
• Similarity: 248/593 - (41%)
• Gaps: 92/593 - (15%)

  Fly    15 SYATTNGNG-KVPNGNGAADLSAPEKQELLRKFSAPAYTEIRTRRCQPKPANDAQSPSSINYHPE 78
            |.||:.|:| |.|  ..||.|| .....:.||.|.....:::......|.|  ||||
Mouse    99 SPATSQGSGSKCP--FLAAQLS-QTGSSVFRKASLELQEDVQEMHAVRKEA--AQSP-------- 150

  Fly    79 KKSIPNGHASILDQESKPNQAEGKLSPELEHFQKTSFEEVPLHTACLTYLGFYLLMILGYINQLL 143
               :|....::......|::.       |::||....::.|...:.|  |...|...:.......
Mouse   151 ---VPPSLVNVKTDGEDPSRL-------LKNFQDIMRKQRPERVSHL--LQDNLPKSVSTFQYDH 203

  Fly   144 FVPKVATEKGRDGYVALYDAFESFYSRYVYRRIKDCWNR----PICSVPGDELTLKDRVTDDYGW 204
            |..|...||..|               :.||..|....|    |:.....|.|..|.:|:   .|
Mouse   204 FFEKKIDEKKND---------------HTYRVFKTVNRRAQIFPMADDYTDSLITKKQVS---VW 250

  Fly   205 SFKFTGTETRCLNLGSYNYLGFAAATGQCADDSEESARSSGLAYCSSRCELGDNEQLQELEALTA 269
                      |.|    :|||.:.....|. ...|:.:..|.....:|...|.::...|||...|
Mouse   251 ----------CSN----DYLGMSRHPRVCG-AVMETVKQHGAGAGGTRNISGTSKFHVELEQALA 300

  Fly   270 RYFGVEDAIVFGMGFATNALNLPSL--LGPNSLVISDEKNHASIILGLRLSGATTKVFKHNNMRD 332
            ...|.:.|::|...|..|...|.:|  :.|...:.||..||||:|.|:|.|.....:|:||::..
Mouse   301 DLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVNH 365

  Fly   333 LERVLRQGVCYGNPKKGGQPWDKVMILVEGIFSMEGSIVRLPEVIALKKKYKAYLYLDEAHSVGA 397
            |..:|::          ..|....::..|.:.||:|::..|.|:..:..::.|..::||.|:||.
Mouse   366 LRELLQR----------SDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGL 420

  Fly   398 MGSRGRGVTDYFNVDPKEVDILMGTFTKSFGSAGGYLAGSKKLIDFLRTNSHAHCYAASISPPIA 462
            .|:||.|:.|...|.|| :||:.||..|:||..|||:|.:..|||.:|:.:....:..|:.|.:.
Mouse   421 YGARGGGIGDRDGVMPK-MDIISGTLGKAFGCVGGYIASTSLLIDTVRSYAAGFIFTTSLPPMLL 484

  Fly   463 QQILTSMKTIMGEDGTDIGRKKIHQLARNTRYFRRRLAQLGVITYGHEDSPVVPMLVYLFSKIGA 527
            ...|.|::.:...:|..:.|:  ||  ||.:..|:.|...|:... |..|.::|:.|...:|...
Mouse   485 AGALESVRILKSSEGRALRRQ--HQ--RNVKLLRQMLMDAGLPVI-HCPSHIIPVRVADAAKNTE 544

  Fly   528 VVRTLTTRHIAAVGA-GFPATPIMEGRIRFCLSAAHTKEQLDFALEAIDEIADDLGLK------- 584
            :...|.|||...|.| .:|..|..|..:|...:..||.:.::|.:|.:......:||:
Mouse   545 ICDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNFFVEKLLVTWKRVGLELKPHSSA 609

  Fly   585 ---YSRKP 589
               :.|:|
Mouse   610 ECNFCRRP 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lace	NP_001285957.1	PLN02483	117..587	CDD:178101	126/486 (26%)
		BioF	164..577	CDD:223234	115/419 (27%)
Alas1	NP_001278764.1	Preseq_ALAS	2..140	CDD:286162	14/43 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..109		5/9 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..163		7/31 (23%)
		AAT_I	199..604	CDD:302748	122/453 (27%)
		BioF	199..600	CDD:223234	120/449 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0156
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810