DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sna and SCRT1

DIOPT Version :9

Sequence 1:	NP_476732.1	Gene:	sna / 34908	FlyBaseID:	FBgn0003448	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_112599.2	Gene:	SCRT1 / 83482	HGNCID:	15950	Length:	348	Species:	Homo sapiens

Alignment Length:	349	Identity:	113/349 - (32%)
Similarity:	156/349 - (44%)	Gaps:	82/349 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 SNSCLLSPPVEAQDYLPTEIHMRGLTAGTTGYTTATPTTINPFQSAFVMAAGCNPISALWSSYQP 146
            |::.|.|....|:..|...:|.:|..:...|     |:::....:...:..|.:|        :|
Human    16 SSADLESAYGRARSDLGAPLHDKGYLSDYVG-----PSSVYDGDAEAALLKGPSP--------EP 67

  Fly   147 HLAAF------PSPASSMASPQSVYSYQQMTPPSSPGSDLET---GSEPEDLSVRNDIPLPALFH 202
            ..||.      |:.|.|             .||.:|..:|.|   |....|.:|.......|.|
Human    68 MYAAAVRGELGPAAAGS-------------APPPTPRPELATAAGGYINGDAAVSEGYAADAFF- 118

  Fly   203 LFD---EAKSSSSGASVSSSSGYSYTPAMSA---------------------------------S 231
            :.|   ..|:|::||:.:.|:..:..|...|                                 .
Human   119 ITDGRSRRKASNAGAAAAPSTASAAAPDGDAGGGGGAGGRSLGSGPGGRGGTRAGAGTEARAGPG 183

  Fly   232 SASVAANHAKNYRFKCDECQKMYSTSMGLSKHRQFHCPAAECNQEKKTHSCEECGKLYTTIGALK 296
            :|.....||      |.||.|.|:||..||:|:|.|    .....:....|..|||:|.::.|:.
Human   184 AAGAGGRHA------CGECGKTYATSSNLSRHKQTH----RSLDSQLARRCPTCGKVYVSMPAMA 238

  Fly   297 MHIRTHTLPCKCPICGKAFSRPWLLQGHIRTHTGEKPFQCPDCPRSFADRSNLRAHQQTHVDVKK 361
            ||:.||.|..||.:||||||||||||||:|:|||||||.|..|.::||||||||||.|||...|.
Human   239 MHLLTHDLRHKCGVCGKAFSRPWLLQGHMRSHTGEKPFGCAHCGKAFADRSNLRAHMQTHSAFKH 303

  Fly   362 YACQVCHKSFSRMSLLNKHSSSNC 385
            :.|:.|.|||:..|.||||..|.|
Human   304 FQCKRCKKSFALKSYLNKHYESAC 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sna	NP_476732.1	C2H2 Zn finger	308..328	CDD:275368	16/19 (84%)
		zf-H2C2_2	321..344	CDD:290200	14/22 (64%)
		zf-C2H2	334..356	CDD:278523	14/21 (67%)
		C2H2 Zn finger	336..356	CDD:275368	13/19 (68%)
		zf-H2C2_2	348..373	CDD:290200	14/24 (58%)
		C2H2 Zn finger	364..380	CDD:275368	8/15 (53%)
		C2H2 Zn finger	247..267	CDD:275368	11/19 (58%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		zf-C2H2	306..328	CDD:278523	17/21 (81%)
		COG5048	307..>356	CDD:227381	37/48 (77%)
SCRT1	NP_112599.2	SNAG domain. /evidence=ECO:0000250	1..20		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..189		7/59 (12%)
		C2H2 Zn finger	224..244	CDD:275368	8/19 (42%)
		COG5048	<245..>313	CDD:227381	44/67 (66%)
		C2H2 Zn finger	250..270	CDD:275368	16/19 (84%)
		C2H2 Zn finger	278..298	CDD:275368	13/19 (68%)
		C2H2 Zn finger	306..322	CDD:275368	8/15 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810