DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sna and SNAI2

DIOPT Version :9

Sequence 1:	NP_476732.1	Gene:	sna / 34908	FlyBaseID:	FBgn0003448	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_003059.1	Gene:	SNAI2 / 6591	HGNCID:	11094	Length:	268	Species:	Homo sapiens

Alignment Length:	321	Identity:	131/321 - (40%)
Similarity:	169/321 - (52%)	Gaps:	68/321 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 NLSKTPERNSSSSSNSCLLSPPVEAQDYLPTEIHMRGLTAGTTGYTTATPTTINPFQSAFVMAAG 133
            |.||.| ..|...:::.::||      ||.....|              |....|    .::::|
Human    12 NASKKP-NYSELDTHTVIISP------YLYESYSM--------------PVIPQP----EILSSG 51

  Fly   134 C-NPISALWSSYQPHLAAFPSPASSMASPQSVYSYQQMTPPSSPGSDLETGSEPEDLSVRNDIPL 197
            . :||: :|::..|..|..|:..|.::...|........|||...|...:|||..
Human    52 AYSPIT-VWTTAAPFHAQLPNGLSPLSGYSSSLGRVSPPPPSDTSSKDHSGSESP---------- 105

  Fly   198 PALFHLFDEAKSSSSGASVSSSSGYSYTPAMSASSASVAANHA-KNYRFKCDECQKMYSTSMGLS 261
                 :.||.:...|                     .::..|| :..:|:|:.|.|.|||..||:
Human   106 -----ISDEEERLQS---------------------KLSDPHAIEAEKFQCNLCNKTYSTFSGLA 144

  Fly   262 KHRQFHCPAAECNQEKKTHSCEECGKLYTTIGALKMHIRTHTLPCKCPICGKAFSRPWLLQGHIR 326
            ||:|.||.|    |.:|:.||:.|.|.|.::||||||||||||||.|.|||||||||||||||||
Human   145 KHKQLHCDA----QSRKSFSCKYCDKEYVSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIR 205

  Fly   327 THTGEKPFQCPDCPRSFADRSNLRAHQQTHVDVKKYACQVCHKSFSRMSLLNKHSSSNCTI 387
            ||||||||.||.|.|:||||||||||.|||.|||||.|:.|.|:|||||||:||..|.|.:
Human   206 THTGEKPFSCPHCNRAFADRSNLRAHLQTHSDVKKYQCKNCSKTFSRMSLLHKHEESGCCV 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sna	NP_476732.1	C2H2 Zn finger	308..328	CDD:275368	18/19 (95%)
		zf-H2C2_2	321..344	CDD:290200	18/22 (82%)
		zf-C2H2	334..356	CDD:278523	16/21 (76%)
		C2H2 Zn finger	336..356	CDD:275368	15/19 (79%)
		zf-H2C2_2	348..373	CDD:290200	17/24 (71%)
		C2H2 Zn finger	364..380	CDD:275368	10/15 (67%)
		C2H2 Zn finger	247..267	CDD:275368	11/19 (58%)
		C2H2 Zn finger	282..302	CDD:275368	12/19 (63%)
		zf-C2H2	306..328	CDD:278523	19/21 (90%)
		COG5048	307..>356	CDD:227381	41/48 (85%)
SNAI2	NP_003059.1	SNAG domain. /evidence=ECO:0000250	1..20		4/8 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..117		11/72 (15%)
		SFP1	<101..182	CDD:227516	39/120 (33%)
		C2H2 Zn finger	130..150	CDD:275370	11/19 (58%)
		C2H2 Zn finger	161..181	CDD:275368	12/19 (63%)
		C2H2 Zn finger	187..207	CDD:275368	18/19 (95%)
		zf-H2C2_2	200..223	CDD:404364	18/22 (82%)
		zf-C2H2	213..235	CDD:395048	16/21 (76%)
		C2H2 Zn finger	215..235	CDD:275368	15/19 (79%)
		C2H2 Zn finger	243..259	CDD:275368	10/15 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11668
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3564
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004977
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	7.020