DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sna and Scrt2

DIOPT Version :9

Sequence 1:	NP_476732.1	Gene:	sna / 34908	FlyBaseID:	FBgn0003448	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_001153882.1	Gene:	Scrt2 / 545474	MGIID:	2139287	Length:	311	Species:	Mus musculus

Alignment Length:	287	Identity:	104/287 - (36%)
Similarity:	139/287 - (48%)	Gaps:	34/287 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 TINPFQSAFVM------------AAGCNPISALWSSYQPHLAAFPSPASSMASPQSVYSYQQMTP 172
            |.:|.::|:|:            .|.|.|.|......:|.|...|:..:..|:....||     .
Mouse    24 TYHPLETAYVLPGTRGPPGDNGYVAHCLPPSGYDGEQKPGLELAPAEPAYPAAASEEYS-----D 83

  Fly   173 PSSPGSDLETGSEPEDLSVRNDIPLPALFHLFDEAKSSSSGASVSSS---------SGYSYTPAM 228
            |.||.|.|.......:.:|.:...:.|.|.....::...:||...::         .|.......
Mouse    84 PESPQSSLSARYFRGEAAVTDSYSMDAFFISDGRSRRRRAGAGGDAAGAGDAGGGGGGGGGGERA 148

  Fly   229 SASSASVAANHAKNYRFKCDECQKMYSTSMGLSKHRQFHCPAAECNQEKKTHSCEECGKLYTTIG 293
            ..|.|:....|    |..|.||.|.|:||..||:|:|.|    .....:....|..|||.|.::.
Mouse   149 GRSGATAGGGH----RHACAECGKTYATSSNLSRHKQTH----RSLDSQLARKCPTCGKAYVSMP 205

  Fly   294 ALKMHIRTHTLPCKCPICGKAFSRPWLLQGHIRTHTGEKPFQCPDCPRSFADRSNLRAHQQTHVD 358
            ||.||:.||.|..||.:||||||||||||||:|:|||||||.|..|.::||||||||||.|||..
Mouse   206 ALAMHVLTHNLRHKCGVCGKAFSRPWLLQGHMRSHTGEKPFGCAHCGKAFADRSNLRAHMQTHSA 270

  Fly   359 VKKYACQVCHKSFSRMSLLNKHSSSNC 385
            .|.|.|:.|.|||:..|.|:||..:.|
Mouse   271 FKHYRCRQCDKSFALKSYLHKHCEAAC 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sna	NP_476732.1	C2H2 Zn finger	308..328	CDD:275368	16/19 (84%)
		zf-H2C2_2	321..344	CDD:290200	14/22 (64%)
		zf-C2H2	334..356	CDD:278523	14/21 (67%)
		C2H2 Zn finger	336..356	CDD:275368	13/19 (68%)
		zf-H2C2_2	348..373	CDD:290200	15/24 (63%)
		C2H2 Zn finger	364..380	CDD:275368	7/15 (47%)
		C2H2 Zn finger	247..267	CDD:275368	11/19 (58%)
		C2H2 Zn finger	282..302	CDD:275368	9/19 (47%)
		zf-C2H2	306..328	CDD:278523	17/21 (81%)
		COG5048	307..>356	CDD:227381	37/48 (77%)
Scrt2	NP_001153882.1	SNAG domain. /evidence=ECO:0000250	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..90		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..156		5/35 (14%)
		C2H2 Zn finger	163..183	CDD:275368	11/19 (58%)
		COG5048	<216..>283	CDD:227381	45/66 (68%)
		zf-C2H2	218..240	CDD:278523	17/21 (81%)
		C2H2 Zn finger	220..240	CDD:275368	16/19 (84%)
		zf-H2C2_2	233..256	CDD:290200	14/22 (64%)
		C2H2 Zn finger	248..268	CDD:275368	13/19 (68%)
		zf-H2C2_2	260..284	CDD:290200	14/23 (61%)
		C2H2 Zn finger	276..292	CDD:275368	7/15 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810