DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sna and Egr3

DIOPT Version :9

Sequence 1:	NP_476732.1	Gene:	sna / 34908	FlyBaseID:	FBgn0003448	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_058782.1	Gene:	Egr3 / 25148	RGDID:	2545	Length:	387	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	87/409 - (21%)
Similarity:	138/409 - (33%)	Gaps:	122/409 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ERLPQTEALALTK--DSQFAQDQPQDLSLKRGRDEETQDYQQ---------------PEPKRDYV 67
            |:||.|.:..|.:  |:.:.::.|..|:|..|..:....|.|               |.|:..|.
  Rat     7 EKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVAHYTQMATENVMDIGLTNEKPNPELSYS 71

  Fly    68 LNLSKTPERNS---------SSSSNSC------LLS------PPVEAQDYLPTEIHMRGLTAGTT 111
            .:....|...:         .|.||.|      |:|      ||                .:|..
  Rat    72 GSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPP----------------ASGAL 120

  Fly   112 GYTTATPTTINPFQSAFVMAAGCNPISALWSSYQPHL---------AAFPSPASSMASPQSVYSY 167
            ...|.|.:.:.|.|         ..:.|::.:..|:.         .:|..|..:.....|...|
  Rat   121 STQTTTASMVQPPQ---------GDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPGLAYSPQDY 176

  Fly   168 QQMTP-------PSSPGSDL-----ETGSEPEDLSVRNDIPL----PALFHLFDEAKSSSSGASV 216
            |...|       |..|..:|     :.||.||....:...|:    |.:..|  |...:.....:
  Rat   177 QSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPL--ETIKAFKDKQI 239

  Fly   217 SSSSGYSYTPAMSASSASVAANHAKNYRFKCDECQKMYSTSMGLSKHRQFHCPAAECNQEKKTHS 281
            ....|....|.::....                            :.|::....::....::.|:
  Rat   240 HPGFGSLPQPPLTLKPI----------------------------RPRKYPNRPSKTPLHERPHA 276

  Fly   282 C--EECGKLYTTIGALKMHIRTHT--LPCKCPICGKAFSRPWLLQGHIRTHTGEKPFQCPDCPRS 342
            |  |.|.:.::....|..|:|.||  .|.:|.||.::|||...|..|||||||||||.|..|.|.
  Rat   277 CPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRK 341

  Fly   343 FADRSNLRAHQQTHVDVKK 361
            ||.....:.|.:.|:..|:
  Rat   342 FARSDERKRHAKIHLKQKE 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sna	NP_476732.1	C2H2 Zn finger	308..328	CDD:275368	10/19 (53%)
		zf-H2C2_2	321..344	CDD:290200	15/22 (68%)
		zf-C2H2	334..356	CDD:278523	7/21 (33%)
		C2H2 Zn finger	336..356	CDD:275368	6/19 (32%)
		zf-H2C2_2	348..373	CDD:290200	3/14 (21%)
		C2H2 Zn finger	364..380	CDD:275368
		C2H2 Zn finger	247..267	CDD:275368	1/19 (5%)
		C2H2 Zn finger	282..302	CDD:275368	6/21 (29%)
		zf-C2H2	306..328	CDD:278523	10/21 (48%)
		COG5048	307..>356	CDD:227381	24/48 (50%)
Egr3	NP_058782.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..283		6/69 (9%)
		zf-C2H2	275..299	CDD:395048	7/23 (30%)
		C2H2 Zn finger	277..299	CDD:275368	6/21 (29%)
		COG5048	303..>375	CDD:227381	27/58 (47%)
		C2H2 Zn finger	307..327	CDD:275368	10/19 (53%)
		zf-H2C2_2	319..344	CDD:404364	16/24 (67%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..387		3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000