DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sna and Snai1

DIOPT Version :9

Sequence 1:	NP_476732.1	Gene:	sna / 34908	FlyBaseID:	FBgn0003448	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_035557.1	Gene:	Snai1 / 20613	MGIID:	98330	Length:	264	Species:	Mus musculus

Alignment Length:	286	Identity:	108/286 - (37%)
Similarity:	142/286 - (49%)	Gaps:	81/286 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 PFQSAFVMAA-----GCNPISAL----WSS-YQPHL-----AAFP---SP----ASSMASPQSVY 165
            |:..|.::||     ..||.::|    |.| ..|.:     |..|   ||    .:|::...|..
Mouse    34 PYDQAHLLAAIPPPEVLNPAASLPTLIWDSLLVPQVRPVAWATLPLRESPKAVELTSLSDEDSGK 98

  Fly   166 SYQQMTPPSSPGSDLETGSEPEDLSVRNDIPLPALFHLFDEAKSSSSGASVSSSSGYSYTPAMSA 230
            |.|..:|||                     |.|:.|       ||:|.:|:.:.:..:: |.:..
Mouse    99 SSQPPSPPS---------------------PAPSSF-------SSTSASSLEAEAFIAF-PGLGQ 134

  Fly   231 SSASVAANHAKNYRFKCDECQKMYSTSMGLSKHRQFHCPAAECNQEKKTHSCEECGKLYTTIGAL 295
            ....:|                              ....|:..|.:|..:|:.|.|.|.::|||
Mouse   135 LPKQLA------------------------------RLSVAKDPQSRKIFNCKYCNKEYLSLGAL 169

  Fly   296 KMHIRTHTLPCKCPICGKAFSRPWLLQGHIRTHTGEKPFQCPDCPRSFADRSNLRAHQQTHVDVK 360
            |||||:|||||.|..||||||||||||||:|||||||||.|..|.|:||||||||||.|||.|||
Mouse   170 KMHIRSHTLPCVCTTCGKAFSRPWLLQGHVRTHTGEKPFSCSHCNRAFADRSNLRAHLQTHSDVK 234

  Fly   361 KYACQVCHKSFSRMSLLNKHSSSNCT 386
            :|.||.|.::|||||||:||..|.|:
Mouse   235 RYQCQACARTFSRMSLLHKHQESGCS 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sna	NP_476732.1	C2H2 Zn finger	308..328	CDD:275368	16/19 (84%)
		zf-H2C2_2	321..344	CDD:290200	16/22 (73%)
		zf-C2H2	334..356	CDD:278523	15/21 (71%)
		C2H2 Zn finger	336..356	CDD:275368	14/19 (74%)
		zf-H2C2_2	348..373	CDD:290200	16/24 (67%)
		C2H2 Zn finger	364..380	CDD:275368	10/15 (67%)
		C2H2 Zn finger	247..267	CDD:275368	0/19 (0%)
		C2H2 Zn finger	282..302	CDD:275368	12/19 (63%)
		zf-C2H2	306..328	CDD:278523	17/21 (81%)
		COG5048	307..>356	CDD:227381	38/48 (79%)
Snai1	NP_035557.1	SNAG domain. /evidence=ECO:0000305	1..20
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000250\|UniProtKB:O95863	2..7
		LATS2 binding. /evidence=ECO:0000250	10..40		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..116		11/58 (19%)
		Destruction motif	95..100		1/4 (25%)
		Required for FBXL14-triggered degradation. /evidence=ECO:0000250	120..151		5/61 (8%)
		Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000250	151..264		76/110 (69%)
		C2H2 Zn finger	156..176	CDD:275368	12/19 (63%)
		COG5048	<177..>253	CDD:227381	58/75 (77%)
		C2H2 Zn finger	182..202	CDD:275368	16/19 (84%)
		zf-H2C2_2	195..218	CDD:290200	16/22 (73%)
		zf-C2H2	208..230	CDD:278523	15/21 (71%)
		C2H2 Zn finger	210..230	CDD:275368	14/19 (74%)
		C2H2 Zn finger	238..255	CDD:275368	11/16 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3568
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.920