DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wor and RPH1

DIOPT Version :9

Sequence 1:	NP_476601.1	Gene:	wor / 34906	FlyBaseID:	FBgn0001983	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_011096.1	Gene:	RPH1 / 856916	SGDID:	S000000971	Length:	796	Species:	Saccharomyces cerevisiae

Alignment Length:	370	Identity:	84/370 - (22%)
Similarity:	136/370 - (36%)	Gaps:	88/370 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 YTRDASPTI------IKAEPSDEEQFPLRNYNNNLLK-------SIAEYED------CMKMQNIK 183
            |:....||:      :|...|.:|| ||    |.|||       .:.::||      ...|.|..
Yeast   439 YSNIVEPTLEDPTLKLKRISSFQEQ-PL----NKLLKRETSQTAMLTDHEDNIVAMSLTSMANSA 498

  Fly   184 EEIPPIPSPQLFYPPPTPLAEPEDLSVTQRRVLSENMNLQNVARALL--------SMQHMAPQHA 240
            ...|.:|..:|........|:|. |.:|...:.....|..:....||        .:.|.|| |:
Yeast   499 ASSPRLPLSRLNSSNELSNAQPL-LDMTNNTLAFPRPNGPSGLNPLLYISNKNISGISHSAP-HS 561

  Fly   241 P--PPIDMEEDQENQDINQLKI-----KSSNDLYYQCQQCNKCYATYAGLVKHQQTHAYESTEYK 298
            |  |.|.:.:..::.:|..|.|     :|...|.|:.:|            :|.|.|:: ||...
Yeast   562 PVNPNISLIKRVKSPNIVTLNISRESSRSPIALNYEARQ------------QHSQQHSF-STPST 613

  Fly   299 IIRSQPGGSGAIVDQTEFCTDQASALIQAANVASAQSMQK---PVGVPRYHCQDCGKSYSTYSGL 360
            :........|.:.|..:..|...    :..|..:|..:.|   ||        :..||....|.:
Yeast   614 VSNLSTSVLGPLSDTNDIKTPHP----ERPNHKTANRILKKESPV--------ETSKSNLILSKV 666

  Fly   361 SKHQQFHCPSAEGNQVKK-----VFSCKNCDKTYVSLGALKMHIRTHTLPCKCPICGKAFSRPWL 420
            :..:|....::..:.:.|     ..:.|...:..|..|..|::|        |..|.:.||....
Yeast   667 ASTRQEDSFTSRNDDLDKEQGSSPLNSKFAPEEIVLSGKNKIYI--------CKECQRKFSSGHH 723

  Fly   421 LQGHIRT-HTGEKPFSCQHCNRAFADRSNLRAHMQTHSDVKKYSC 464
            |..|.:: |:||||.||..|.:.|..|.::..|:.     ||..|
Yeast   724 LTRHKKSVHSGEKPHSCPKCGKRFKRRDHVLQHLN-----KKIPC 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wor	NP_476601.1	C2H2 Zn finger	270..290	CDD:275368	3/19 (16%)
		C2H2 Zn finger	317..334	CDD:275368	2/16 (13%)
		zf-C2H2	345..367	CDD:278523	4/21 (19%)
		C2H2 Zn finger	347..367	CDD:275368	4/19 (21%)
		PHA00732	379..>417	CDD:177300	8/37 (22%)
		C2H2 Zn finger	382..402	CDD:275368	5/19 (26%)
		zf-C2H2_8	405..482	CDD:292531	20/61 (33%)
		zf-C2H2	406..428	CDD:278523	6/22 (27%)
		C2H2 Zn finger	408..428	CDD:275368	6/20 (30%)
		zf-H2C2_2	421..444	CDD:290200	10/23 (43%)
		zf-C2H2	434..456	CDD:278523	6/21 (29%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		zf-H2C2_2	448..473	CDD:290200	4/17 (24%)
		C2H2 Zn finger	464..481	CDD:275368	1/1 (100%)
RPH1	NP_011096.1	JmjN	13..54	CDD:128818
		JmjC	222..338	CDD:396791
		COG5048	507..>759	CDD:227381	62/291 (21%)
		C2H2 Zn finger	711..732	CDD:275368	6/20 (30%)
		C2H2 Zn finger	740..757	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2499
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950