DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wor and SCRT2

DIOPT Version :9

Sequence 1:	NP_476601.1	Gene:	wor / 34906	FlyBaseID:	FBgn0001983	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_149120.1	Gene:	SCRT2 / 85508	HGNCID:	15952	Length:	307	Species:	Homo sapiens

Alignment Length:	194	Identity:	95/194 - (48%)
Similarity:	113/194 - (58%)	Gaps:	19/194 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 GGSGAIVDQTEFCTDQASALIQAANVASAQSMQKPVGVPRYHCQDCGKSYSTYSGLSKHQQFHCP 369
            ||||           .|......|..|.||:    .|..|:.|.:|||:|:|.|.||:|:|.| .
Human   130 GGSG-----------DAGGAGGRAGRAGAQA----GGGHRHACAECGKTYATSSNLSRHKQTH-R 178

  Fly   370 SAEGNQVKKVFSCKNCDKTYVSLGALKMHIRTHTLPCKCPICGKAFSRPWLLQGHIRTHTGEKPF 434
            |.:....:|   |..|.|.|||:.||.||:.||.|..||.:||||||||||||||:|:|||||||
Human   179 SLDSQLARK---CPTCGKAYVSMPALAMHLLTHNLRHKCGVCGKAFSRPWLLQGHMRSHTGEKPF 240

  Fly   435 SCQHCNRAFADRSNLRAHMQTHSDVKKYSCPTCTKSFSRMSLLAKHLQSGCQTEQSGGPSGSGG 498
            .|.||.:||||||||||||||||..|.|.|..|.|||:..|.|.||.::.|.......|....|
Human   241 GCAHCGKAFADRSNLRAHMQTHSAFKHYRCRQCDKSFALKSYLHKHCEAACAKAAEPPPPTPAG 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wor	NP_476601.1	C2H2 Zn finger	270..290	CDD:275368
		C2H2 Zn finger	317..334	CDD:275368	3/16 (19%)
		zf-C2H2	345..367	CDD:278523	11/21 (52%)
		C2H2 Zn finger	347..367	CDD:275368	11/19 (58%)
		PHA00732	379..>417	CDD:177300	20/37 (54%)
		C2H2 Zn finger	382..402	CDD:275368	10/19 (53%)
		zf-C2H2_8	405..482	CDD:292531	54/76 (71%)
		zf-C2H2	406..428	CDD:278523	17/21 (81%)
		C2H2 Zn finger	408..428	CDD:275368	16/19 (84%)
		zf-H2C2_2	421..444	CDD:290200	16/22 (73%)
		zf-C2H2	434..456	CDD:278523	17/21 (81%)
		C2H2 Zn finger	436..456	CDD:275368	16/19 (84%)
		zf-H2C2_2	448..473	CDD:290200	17/24 (71%)
		C2H2 Zn finger	464..481	CDD:275368	8/16 (50%)
SCRT2	NP_149120.1	SNAG domain. /evidence=ECO:0000250	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..90
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..148		7/28 (25%)
		C2H2 Zn finger	157..177	CDD:275368	11/19 (58%)
		COG5048	<210..>277	CDD:227381	49/66 (74%)
		C2H2 Zn finger	214..234	CDD:275368	16/19 (84%)
		zf-H2C2_2	227..250	CDD:290200	16/22 (73%)
		C2H2 Zn finger	242..262	CDD:275368	16/19 (84%)
		zf-H2C2_2	254..278	CDD:290200	16/23 (70%)
		C2H2 Zn finger	270..286	CDD:275368	7/15 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810