DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wor and ces-1

DIOPT Version :9

Sequence 1:	NP_476601.1	Gene:	wor / 34906	FlyBaseID:	FBgn0001983	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_492338.1	Gene:	ces-1 / 185718	WormBaseID:	WBGene00000468	Length:	270	Species:	Caenorhabditis elegans

Alignment Length:	301	Identity:	99/301 - (32%)
Similarity:	145/301 - (48%)	Gaps:	40/301 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 IPSPQLFYPPPTPLAEPEDLSVTQRRVLSENMNLQNVARALLSMQHMAPQHAPPPIDMEEDQENQ 253
            |.:|.:...|  .:|.|.|..:.      .|.:.|.....|:|: |:..|.:...........:.
Worm     2 ITTPNISLTP--TVAPPVDFPII------GNCDFQAQLWHLMSL-HLQMQKSSAASTSSSSSSST 57

  Fly   254 DINQLKIKSSNDLYYQCQQCNKCYATYAGLVKHQQTHAYESTEYKIIRSQPGGSGAIVDQTEFCT 318
            ....|| ||.:.:.      |....:...::..|:....|....:.:.|.|..:         |:
Worm    58 SSENLK-KSPSSVQ------NTSVFSIDNILNSQKVPKLELENDEDVSSSPSPT---------CS 106

  Fly   319 DQASALIQAANVASAQSMQK--PVGVPRYHCQDCGKSYSTYSGLSKHQQFH----CPSAEGNQVK 377
            .....|....|: ..:|:.|  |....|..|..|||||:|.|.||:|:|.|    .|.|:
Worm   107 TTGYTLDSLQNL-DRRSLNKKGPSSHNRCVCDKCGKSYATTSNLSRHKQTHRALDSPHAK----- 165

  Fly   378 KVFSCKNCDKTYVSLGALKMHIRTHTLPCKCPICGKAFSRPWLLQGHIRTHTGEKPFSCQHCNRA 442
               .|.:||:.|||:.||.|||.||....:|.:|||.|||.||||||:|:|||.:||||.||.::
Worm   166 ---QCPHCDRVYVSMPALSMHILTHNASHECNVCGKRFSRLWLLQGHLRSHTGLRPFSCAHCGKS 227

  Fly   443 FADRSNLRAHMQTHSDVKKYSCPTCTKSFSRMSLLAKHLQS 483
            |||||||||||.||:..|::.|..|.:.|:..:.|.:||::
Worm   228 FADRSNLRAHMLTHTGDKRFECDKCGRRFALRAYLNRHLET 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wor	NP_476601.1	C2H2 Zn finger	270..290	CDD:275368	2/19 (11%)
		C2H2 Zn finger	317..334	CDD:275368	3/16 (19%)
		zf-C2H2	345..367	CDD:278523	12/21 (57%)
		C2H2 Zn finger	347..367	CDD:275368	12/19 (63%)
		PHA00732	379..>417	CDD:177300	18/37 (49%)
		C2H2 Zn finger	382..402	CDD:275368	11/19 (58%)
		zf-C2H2_8	405..482	CDD:292531	42/76 (55%)
		zf-C2H2	406..428	CDD:278523	14/21 (67%)
		C2H2 Zn finger	408..428	CDD:275368	14/19 (74%)
		zf-H2C2_2	421..444	CDD:290200	14/22 (64%)
		zf-C2H2	434..456	CDD:278523	16/21 (76%)
		C2H2 Zn finger	436..456	CDD:275368	14/19 (74%)
		zf-H2C2_2	448..473	CDD:290200	12/24 (50%)
		C2H2 Zn finger	464..481	CDD:275368	4/16 (25%)
ces-1	NP_492338.1	C2H2 Zn finger	167..187	CDD:275368	11/19 (58%)
		C2H2 Zn finger	193..213	CDD:275368	14/19 (74%)
		zf-H2C2_2	206..229	CDD:290200	14/22 (64%)
		zf-C2H2	219..241	CDD:278523	16/21 (76%)
		C2H2 Zn finger	221..241	CDD:275368	14/19 (74%)
		zf-H2C2_2	233..257	CDD:290200	11/23 (48%)
		C2H2 Zn finger	249..268	CDD:275368	6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910