Protein Alignment esg and ZBTB16

DIOPT Version :10

• Sequence 1: NP_476600.1
• Gene: esg / 34903
• FlyBaseID: FBgn0287768
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_005997.2
• Gene: ZBTB16 / 7704
• HGNCID: 12930
• Length: 673
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 126/560 - (22%)
• Similarity: 195/560 - (34%)
• Gaps: 170/560 - (30%)

  Fly    41 QDLCVKKMEIL---EENPSEELINVSDCCEDEGVDVDHTDD----EHIEEEDEDVDVD------- 91
            ::.|:|.:|.:   ::|.:|..:......|:|.....:..:    :|..||.....|.
Human   115 EEQCLKMLETIQASDDNDTEATMADGGAEEEEDRKARYLKNIFISKHSSEESGYASVAGQSLPGP 179

  Fly    92 -VDSDPNQTQAAALAAAAAVAAAAAASVVV-----------PT-PTYPKYPWNNFHMSPYTAEFY 143
             ||..|:.:.:..|:|.:...||..:.:.:           |. |..|.......|  |..|| .
Human   180 MVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTLQPPAGPEEPTLAGGGRH--PGVAE-V 241

  Fly   144 RTINQQGHQILPLR--------------GDLI------APSSPSDSLGSLSPPPHHYLHGR---A 185
            :|...|..:: |.:              ||.:      .|.:|:.|....|....||  ||   |
Human   242 KTEMMQVDEV-PSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRSSVITSARELHY--GREESA 303

  Fly   186 SSVSPPMRSEIIHRPIGVRQHRFLPYPQMPGYPSLGGYTHTHHHHAP--------------ISPA 236
            ..|.||  :|....|.|..:|     |..|....||.|:...:|.|.              :.||
Human   304 EQVPPP--AEAGQAPTGRPEH-----PAPPPEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQPA 361

  Fly   237 YSENSYYS-------------------------MRSMTPE-----SSCSSSLPEDLSL-KHKNL- 269
            .:.:..:|                         |:|.:..     |.|...||::.:: :|:.|
Human   362 LAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKSESRTIGEQCSVCGVELPDNEAVEQHRKLH 426

  Fly   270 -----------------NLNLNTSQPGEQAAAKT-------GDMSPETMPNASAKKDKNQPPRYQ 310
                             :|.|........|.||.       ...|.|.......:..........
Human   427 SGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVF 491

  Fly   311 CPDCQKSYSTFSGLTKHQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGALKMHIRTHT-------- 367
            |..|.|.:...|.|.:|.:.|...       :|:.|.:|::|:.|..|||.|:|:||
Human   492 CLLCGKRFQAQSALQQHMEVHAGV-------RSYICSECNRTFPSHTALKRHLRSHTGDHPYECE 549

  Fly   368 ----------------------LPCKCNLCGKAFSRPWLLQGHIRTHTGEKPFSCQHCHRAFADR 410
                                  .|.:||.|||.||....|:.|.|.|||||||.|:.||:...|.
Human   550 FCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDY 614

  Fly   411 SNLRAHLQTHSDIKKYSCTSCSKTFSRMSLLTKHSEGGCP 450
            |.:..||:||:....|.||.|::....:|.:.||.:|..|
Human   615 SAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKP 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	KREPA	<278..>329	CDD:483960	11/57 (19%)
		zf-C2H2	309..331	CDD:395048	6/21 (29%)
		C2H2 Zn finger	311..331	CDD:275370	6/19 (32%)
		zf-C2H2	344..366	CDD:395048	9/21 (43%)
		C2H2 Zn finger	346..366	CDD:275368	9/19 (47%)
		zf-C2H2	370..392	CDD:395048	10/21 (48%)
		C2H2 Zn finger	372..392	CDD:275368	10/19 (53%)
		zf-H2C2_2	385..408	CDD:463886	13/22 (59%)
		zf-C2H2	398..420	CDD:395048	8/21 (38%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	428..444	CDD:275368	4/15 (27%)
ZBTB16	NP_005997.2	BTB_POZ_ZBTB16_PLZF	16..122	CDD:349514	2/6 (33%)
		PHA03307	177..>327	CDD:223039	36/162 (22%)
		Interaction with RUNX1T1. /evidence=ECO:0000269|PubMed:10688654	200..300		21/105 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..236		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	249..332		21/92 (23%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		C2H2 Zn finger	434..454	CDD:275368	2/19 (11%)
		COG5048	<448..622	CDD:227381	48/180 (27%)
		C2H2 Zn finger	463..483	CDD:275368	2/19 (11%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	9/19 (47%)
		C2H2 Zn finger	548..568	CDD:275368	0/19 (0%)
		C2H2 Zn finger	576..596	CDD:275368	10/19 (53%)
		C2H2 Zn finger	604..624	CDD:275368	7/19 (37%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)