Protein Alignment esg and ZIC3

DIOPT Version :10

• Sequence 1: NP_476600.1
• Gene: esg / 34903
• FlyBaseID: FBgn0287768
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_003404.1
• Gene: ZIC3 / 7547
• HGNCID: 12874
• Length: 467
• Species: Homo sapiens
• Alignment Length: 449
• Identity: 114/449 - (25%)
• Similarity: 161/449 - (35%)
• Gaps: 160/449 - (35%)

  Fly   107 AAAVAAAAAASVVVPTPTYPKYPWNNFHMSPYTAEFYRTINQQGHQILPLRGDLIAP--SSPSDS 169
            |||.||||||                |.:||..|          |.:...:.....|  |..:::
Human    46 AAAAAAAAAA----------------FKLSPAAA----------HDLSSGQSSAFTPQGSGYANA 84

  Fly   170 LGSLSPPPHHYLH--------GRASSVSPPMR---------------------------SEIIHR 199
            ||......||:.|        |.||:.....|                           :..:|.
Human    85 LGHHHHHHHHHHHTSQVPSYGGAASAAFNSTREFLFRQRSSGLSEAASGGGQHGLFAGSASSLHA 149

  Fly   200 PIGVRQ-HRFLPYP----QMPGYPSLGGYTHTHHHHA-----------PISPAYSENSYYSMRSM 248
            |.|:.: ..:|.:|    |..|:||..|:...:..|.           |..|..|..
Human   150 PAGIPEPPSYLLFPGLHEQGAGHPSPTGHVDNNQVHLGLRGELFGRADPYRPVASPR-------- 206

  Fly   249 TPESSCSSSLPEDLSLKHKNLNLNLNTS-------------QPGEQAAAKTGDMSPETMPNASAK 300
            |...:..:..|   :....|:|:.:|.:             ||.:|      ::|.:.:..|...
Human   207 TDPYAAGAQFP---NYSPMNMNMGVNVAAHHGPGAFFRYMRQPIKQ------ELSCKWIDEAQLS 262

  Fly   301 KDKNQPPRYQCPDCQKSYSTFSGLTKH----------QQFH------CPAAEGNQVKKSFSCKDC 349
            :.|.        .|.:::||...|..|          |..|      || .||    |||..|
Human   263 RPKK--------SCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECP-REG----KSFKAK-- 312

  Fly   350 DKTYVSLGALKMHIRTHT----LPCKCNLCGKAFSRPWLLQGHIRTHTGEKPFSCQH--CHRAFA 408
               |    .|..|||.||    .||....|||.|:|...|:.|.|||||||||.|:.  |.|.||
Human   313 ---Y----KLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFA 370

  Fly   409 DRSNLRAHLQTHSDIKKYSCTSCSKTFSRMSLLTKH-----SEG--GCPGGSAGSSSSS 460
            :.|:.:.|:..|:..|.|.|..|.|:::..|.|.||     |:|  ..|..|:|..||:
Human   371 NSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSDSSPAASSGYESST 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	KREPA	<278..>329	CDD:483960	10/60 (17%)
		zf-C2H2	309..331	CDD:395048	6/31 (19%)
		C2H2 Zn finger	311..331	CDD:275370	6/29 (21%)
		zf-C2H2	344..366	CDD:395048	7/21 (33%)
		C2H2 Zn finger	346..366	CDD:275368	6/19 (32%)
		zf-C2H2	370..392	CDD:395048	9/21 (43%)
		C2H2 Zn finger	372..392	CDD:275368	8/19 (42%)
		zf-H2C2_2	385..408	CDD:463886	14/24 (58%)
		zf-C2H2	398..420	CDD:395048	8/23 (35%)
		C2H2 Zn finger	400..420	CDD:275368	7/21 (33%)
		C2H2 Zn finger	428..444	CDD:275368	5/15 (33%)
ZIC3	NP_003404.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..107		7/40 (18%)
		zf_ZIC	245..290	CDD:436441	11/58 (19%)
		Nuclear localization signal	297..322		13/38 (34%)
		C2H2 Zn finger	302..322	CDD:275368	13/33 (39%)
		SFP1	<324..408	CDD:227516	35/83 (42%)
		C2H2 Zn finger	330..352	CDD:275368	9/21 (43%)
		Nuclear localization signal	330..352		9/21 (43%)
		C2H2 Zn finger	360..382	CDD:275368	7/21 (33%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..467		9/26 (35%)