Protein Alignment esg and SNAI1

DIOPT Version :10

• Sequence 1: NP_476600.1
• Gene: esg / 34903
• FlyBaseID: FBgn0287768
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_005976.2
• Gene: SNAI1 / 6615
• HGNCID: 11128
• Length: 264
• Species: Homo sapiens
• Alignment Length: 301
• Identity: 120/301 - (39%)
• Similarity: 151/301 - (50%)
• Gaps: 61/301 - (20%)

  Fly   163 PSSPS-----DSLGSLSP-----PPHHYLHGRASSVSPPMRSEIIHRPIGVRQHRFLPYPQMPGY 217
            ||.|:     ..|...:|     .|:...|..|:...|.:.:.....|:.:......|..|...:
Human    10 PSDPNRKPNYSELQDSNPEFTFQQPYDQAHLLAAIPPPEILNPTASLPMLIWDSVLAPQAQPIAW 74

  Fly   218 PSLGGYTHTHHHHAPISPAYSENSYYSMRSMTPESSCSSSLPEDLSLKHKNLNLNLNTSQPGEQA 282
            .||         ....||..:|     :.|::.|.|...|.|.             :...|...:
Human    75 ASL---------RLQESPRVAE-----LTSLSDEDSGKGSQPP-------------SPPSPAPSS 112

  Fly   283 AAKTGDMSPETMPNASAKKDKNQPPRYQCPDCQKSYSTFSGL--TKHQQFHCPAAEGNQVKKSFS 345
            .:.|...|.|.                      ::|:.|.||  ...|......|:..|.:|:|:
Human   113 FSSTSVSSLEA----------------------EAYAAFPGLGQVPKQLAQLSEAKDLQARKAFN 155

  Fly   346 CKDCDKTYVSLGALKMHIRTHTLPCKCNLCGKAFSRPWLLQGHIRTHTGEKPFSCQHCHRAFADR 410
            ||.|:|.|:||||||||||:|||||.|..||||||||||||||:|||||||||||.||.||||||
Human   156 CKYCNKEYLSLGALKMHIRSHTLPCVCGTCGKAFSRPWLLQGHVRTHTGEKPFSCPHCSRAFADR 220

  Fly   411 SNLRAHLQTHSDIKKYSCTSCSKTFSRMSLLTKHSEGGCPG 451
            ||||||||||||:|||.|.:|::||||||||.||.|.||.|
Human   221 SNLRAHLQTHSDVKKYQCQACARTFSRMSLLHKHQESGCSG 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	KREPA	<278..>329	CDD:483960	8/52 (15%)
		zf-C2H2	309..331	CDD:395048	5/23 (22%)
		C2H2 Zn finger	311..331	CDD:275370	5/21 (24%)
		zf-C2H2	344..366	CDD:395048	16/21 (76%)
		C2H2 Zn finger	346..366	CDD:275368	15/19 (79%)
		zf-C2H2	370..392	CDD:395048	17/21 (81%)
		C2H2 Zn finger	372..392	CDD:275368	16/19 (84%)
		zf-H2C2_2	385..408	CDD:463886	19/22 (86%)
		zf-C2H2	398..420	CDD:395048	19/21 (90%)
		C2H2 Zn finger	400..420	CDD:275368	17/19 (89%)
		C2H2 Zn finger	428..444	CDD:275368	10/15 (67%)
SNAI1	NP_005976.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		4/16 (25%)
		SNAG domain. /evidence=ECO:0000305|PubMed:20389281, ECO:0000305|PubMed:21300290	1..20		3/9 (33%)
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:23721412	2..7
		LATS2 binding	10..40		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	86..115		7/46 (15%)
		Destruction motif	95..100		1/4 (25%)
		Required for FBXL14-triggered degradation	120..151		9/52 (17%)
		Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000269|PubMed:21577210, ECO:0000269|PubMed:22128911	151..264		87/111 (78%)
		C2H2 Zn finger	156..176	CDD:275368	15/19 (79%)
		C2H2 Zn finger	182..202	CDD:275368	16/19 (84%)
		zf-H2C2_2	195..218	CDD:463886	19/22 (86%)
		zf-C2H2	208..230	CDD:395048	19/21 (90%)
		C2H2 Zn finger	210..230	CDD:275368	17/19 (89%)
		C2H2 Zn finger	238..255	CDD:275368	11/16 (69%)