Protein Alignment esg and SNAI2

DIOPT Version :10

• Sequence 1: NP_476600.1
• Gene: esg / 34903
• FlyBaseID: FBgn0287768
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_003059.1
• Gene: SNAI2 / 6591
• HGNCID: 11094
• Length: 268
• Species: Homo sapiens
• Alignment Length: 291
• Identity: 145/291 - (49%)
• Similarity: 175/291 - (60%)
• Gaps: 46/291 - (15%)

  Fly   177 PHHYL---HGRASSVSPPMRSEIIHRPIGVRQHRFLPYPQMPGYP-----SLGGYTHTHHHHAPI 233
            |..:|   |..||  ..|..||:....:.:..:.:..| .||..|     |.|.|       :||
Human     2 PRSFLVKKHFNAS--KKPNYSELDTHTVIISPYLYESY-SMPVIPQPEILSSGAY-------SPI 56

  Fly   234 SPAYSENSYYSM--RSMTPESSCSSSL-------PEDLSLK-HKNLNLNLNTSQPGEQAAAKTGD 288
            :...:...:::.  ..::|.|..||||       |.|.|.| |......::..:  |:..:|..|
Human    57 TVWTTAAPFHAQLPNGLSPLSGYSSSLGRVSPPPPSDTSSKDHSGSESPISDEE--ERLQSKLSD 119

  Fly   289 MSPETMPNASAKKDKNQPPRYQCPDCQKSYSTFSGLTKHQQFHCPAAEGNQVKKSFSCKDCDKTY 353
                  |:|.      :..::||..|.|:|||||||.||:|.||.|    |.:||||||.|||.|
Human   120 ------PHAI------EAEKFQCNLCNKTYSTFSGLAKHKQLHCDA----QSRKSFSCKYCDKEY 168

  Fly   354 VSLGALKMHIRTHTLPCKCNLCGKAFSRPWLLQGHIRTHTGEKPFSCQHCHRAFADRSNLRAHLQ 418
            |||||||||||||||||.|.:||||||||||||||||||||||||||.||:||||||||||||||
Human   169 VSLGALKMHIRTHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCPHCNRAFADRSNLRAHLQ 233

  Fly   419 THSDIKKYSCTSCSKTFSRMSLLTKHSEGGC 449
            ||||:|||.|.:|||||||||||.||.|.||
Human   234 THSDVKKYQCKNCSKTFSRMSLLHKHEESGC 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	KREPA	<278..>329	CDD:483960	18/50 (36%)
		zf-C2H2	309..331	CDD:395048	14/21 (67%)
		C2H2 Zn finger	311..331	CDD:275370	13/19 (68%)
		zf-C2H2	344..366	CDD:395048	19/21 (90%)
		C2H2 Zn finger	346..366	CDD:275368	17/19 (89%)
		zf-C2H2	370..392	CDD:395048	18/21 (86%)
		C2H2 Zn finger	372..392	CDD:275368	17/19 (89%)
		zf-H2C2_2	385..408	CDD:463886	20/22 (91%)
		zf-C2H2	398..420	CDD:395048	19/21 (90%)
		C2H2 Zn finger	400..420	CDD:275368	17/19 (89%)
		C2H2 Zn finger	428..444	CDD:275368	12/15 (80%)
SNAI2	NP_003059.1	SNAG domain. /evidence=ECO:0000250|UniProtKB:O95863	1..20		6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..117		10/38 (26%)
		SFP1	<101..182	CDD:227516	45/98 (46%)
		C2H2 Zn finger	130..150	CDD:275370	13/19 (68%)
		C2H2 Zn finger	161..181	CDD:275368	17/19 (89%)
		C2H2 Zn finger	187..207	CDD:275368	17/19 (89%)
		zf-H2C2_2	200..223	CDD:463886	20/22 (91%)
		zf-C2H2	213..235	CDD:395048	19/21 (90%)
		C2H2 Zn finger	215..235	CDD:275368	17/19 (89%)
		C2H2 Zn finger	243..259	CDD:275368	12/15 (80%)