Protein Alignment esg and zic2

DIOPT Version :10

• Sequence 1: NP_476600.1
• Gene: esg / 34903
• FlyBaseID: FBgn0287768
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_001017025.2
• Gene: zic2 / 549779
• XenbaseID: XB-GENE-482654
• Length: 501
• Species: Xenopus tropicalis
• Alignment Length: 428
• Identity: 110/428 - (25%)
• Similarity: 150/428 - (35%)
• Gaps: 128/428 - (29%)

  Fly    94 SDPNQTQ---------AAALAAAAAVAAAAAASVVVPTPTYPK---------------------- 127
            |.|.||.         |:|||..||...||..|        |:
 Frog    98 SPPGQTSAFTSQAGYPASALAPHAAYTGAAFNS--------PRDFLFRGRGFAEGTAAAGGGQHG 154

  Fly   128 ---YPWNNFHMSPYTAEFYRTINQQGHQILPLRGDLIAPSSPSDSLGS---LSPPPHHYLHGRAS 186
               .|..:.|..|:..:.....:.|||.:.|...|..|.:| .::||.   |..|..  :.||..
 Frog   155 LFGPPAGSLHHHPHHHQLSHGEHPQGHILFPGIHDQHAAAS-QNALGGQMRLGLPGE--MFGRTE 216

  Fly   187 SV----SP---PMRSEIIHRPIGVRQHRFLPYPQMPGYPSLGGYTHTHHHHAPISPAYSENSYYS 244
            ..    ||   |..:..:|.          .|..|....::..:.|.||||.|  .|:..  |..
 Frog   217 QYRQVSSPRGDPYTAAQLHN----------QYAPMNMGMNMAAHHHHHHHHHP--GAFFR--YMR 267

  Fly   245 MRSMTPESSCSSSLPEDLSLKHKNLNLNLNTSQPGEQAAAKTGDMSPETMPNASAKKDKNQPPRY 309
            .:.:..|..|....||.||...|:
 Frog   268 QQCIKQELICKWIDPEQLSNPKKS----------------------------------------- 291

  Fly   310 QCPDCQKSYSTFSGLTKHQQF-HCPAAE-GNQVKKSFSCKDCDKTYVSLGALKMHIRTHT----L 368
                |.|::||...|..|... |....| .|.:.....|....|.:.:...|..|||.||    .
 Frog   292 ----CNKTFSTMHELVTHVSVEHVGGPEQSNHICFWEECSREGKPFKAKYKLVNHIRVHTGEKPF 352

  Fly   369 PCKCNLCGKAFSRPWLLQGHIRTHTGEKPFSCQH--CHRAFADRSNLRAHLQTHSDIKKYSCTSC 431
            ||....|||.|:|...|:.|.|||||||||.|:.  |.|.||:.|:.:.|:..|:..|.|.|..|
 Frog   353 PCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMC 417

  Fly   432 SKTFSRMSLLTKHSE--GGCPGGSAGSSSSSELNYAGY 467
            .|:::..|.|.||.:  ...|.||..|.::|    :||
 Frog   418 DKSYTHPSSLRKHMKVHESSPQGSESSPAAS----SGY 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	KREPA	<278..>329	CDD:483960	6/50 (12%)
		zf-C2H2	309..331	CDD:395048	6/22 (27%)
		C2H2 Zn finger	311..331	CDD:275370	6/20 (30%)
		zf-C2H2	344..366	CDD:395048	6/21 (29%)
		C2H2 Zn finger	346..366	CDD:275368	6/19 (32%)
		zf-C2H2	370..392	CDD:395048	9/21 (43%)
		C2H2 Zn finger	372..392	CDD:275368	8/19 (42%)
		zf-H2C2_2	385..408	CDD:463886	14/24 (58%)
		zf-C2H2	398..420	CDD:395048	8/23 (35%)
		C2H2 Zn finger	400..420	CDD:275368	7/21 (33%)
		C2H2 Zn finger	428..444	CDD:275368	5/15 (33%)
zic2	NP_001017025.2	zf_ZIC	269..314	CDD:436441	14/89 (16%)
		COG5048	<284..438	CDD:227381	55/198 (28%)
		C2H2 Zn finger	324..346	CDD:275368	6/21 (29%)
		C2H2 Zn finger	354..376	CDD:275368	9/21 (43%)
		C2H2 Zn finger	384..406	CDD:275368	7/21 (33%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)