DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment esg and Scrt2

DIOPT Version :9

Sequence 1:	NP_476600.1	Gene:	esg / 34903	FlyBaseID:	FBgn0001981	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001153882.1	Gene:	Scrt2 / 545474	MGIID:	2139287	Length:	311	Species:	Mus musculus

Alignment Length:	335	Identity:	115/335 - (34%)
Similarity:	158/335 - (47%)	Gaps:	43/335 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 NNFHMSPYTAEFYRTINQQGHQILPLRGDLIAPSSPSDSLGSLSPPPHHYLHGRASSVSPPMRSE 195
            :.|..|..:|..|.          ||....:.|       |:..||..   :|..:...||...:
Mouse    13 DGFQCSGVSAPTYH----------PLETAYVLP-------GTRGPPGD---NGYVAHCLPPSGYD 57

  Fly   196 IIHRPIGVRQHRFLPYPQMPGYPSLGGYTHTHHHHAPISPAYSENSYY--SMRSMTPESSCSSSL 258
            ...:| |:..     .|..|.||:..    :..:..|.||..|.::.|  ...::|...|..:..
Mouse    58 GEQKP-GLEL-----APAEPAYPAAA----SEEYSDPESPQSSLSARYFRGEAAVTDSYSMDAFF 112

  Fly   259 PEDLSLKHKNLNLNLNTSQPGEQAAAKTGDMSPETMPNASAKKDKNQPPRYQCPDCQKSYSTFSG 323
            ..|...:.:......:.:..|:......|....|....:.|......  |:.|.:|.|:|:|.|.
Mouse   113 ISDGRSRRRRAGAGGDAAGAGDAGGGGGGGGGGERAGRSGATAGGGH--RHACAECGKTYATSSN 175

  Fly   324 LTKHQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGALKMHIRTHTLPCKCNLCGKAFSRPWLLQGH 388
            |::|:|.| .:.:....:|   |..|.|.|||:.||.||:.||.|..||.:||||||||||||||
Mouse   176 LSRHKQTH-RSLDSQLARK---CPTCGKAYVSMPALAMHVLTHNLRHKCGVCGKAFSRPWLLQGH 236

  Fly   389 IRTHTGEKPFSCQHCHRAFADRSNLRAHLQTHSDIKKYSCTSCSKTFSRMSLLTKHSEGGC---- 449
            :|:|||||||.|.||.:|||||||||||:||||..|.|.|..|.|:|:..|.|.||.|..|
Mouse   237 MRSHTGEKPFGCAHCGKAFADRSNLRAHMQTHSAFKHYRCRQCDKSFALKSYLHKHCEAACVKAA 301

  Fly   450 -PGGSAGSSS 458
             |..|||.:|
Mouse   302 EPPPSAGPAS 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	zf-C2H2	309..331	CDD:278523	9/21 (43%)
		C2H2 Zn finger	311..331	CDD:275370	9/19 (47%)
		zf-C2H2	344..366	CDD:278523	10/21 (48%)
		C2H2 Zn finger	346..366	CDD:275368	10/19 (53%)
		zf-C2H2	370..392	CDD:278523	17/21 (81%)
		C2H2 Zn finger	372..392	CDD:275368	16/19 (84%)
		zf-H2C2_2	385..408	CDD:290200	16/22 (73%)
		zf-C2H2	398..420	CDD:278523	16/21 (76%)
		C2H2 Zn finger	400..420	CDD:275368	15/19 (79%)
		C2H2 Zn finger	428..444	CDD:275368	6/15 (40%)
Scrt2	NP_001153882.1	SNAG domain. /evidence=ECO:0000250	1..20		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..90		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..156		4/35 (11%)
		C2H2 Zn finger	163..183	CDD:275368	9/19 (47%)
		COG5048	<216..>283	CDD:227381	48/66 (73%)
		zf-C2H2	218..240	CDD:278523	17/21 (81%)
		C2H2 Zn finger	220..240	CDD:275368	16/19 (84%)
		zf-H2C2_2	233..256	CDD:290200	16/22 (73%)
		C2H2 Zn finger	248..268	CDD:275368	15/19 (79%)
		zf-H2C2_2	260..284	CDD:290200	14/23 (61%)
		C2H2 Zn finger	276..292	CDD:275368	6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I4034
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860