DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment esg and snai2

DIOPT Version :9

Sequence 1:	NP_476600.1	Gene:	esg / 34903	FlyBaseID:	FBgn0001981	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001008581.1	Gene:	snai2 / 494038	ZFINID:	ZDB-GENE-030326-6	Length:	257	Species:	Danio rerio

Alignment Length:	274	Identity:	134/274 - (48%)
Similarity:	164/274 - (59%)	Gaps:	42/274 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 SSVSPPMRSEIIHRPIGVRQH--RFLPYPQMP--------GYPSLGGYTHTHHHHAPISPAYSEN 240
            ::...|..||:....:.:..:  :.||.|.:|        .|..:..:|.:   :.|:||.
Zfish    12 NAAKKPNYSELESPTVFISPYVLKALPVPVIPQPEVLSPVAYNPITVWTTS---NLPLSPL---- 69

  Fly   241 SYYSMRSMTPESSCSSSLPEDLSLKHKNLNLNLNTSQPGEQAAAKTGDMSPETMPNASAKKDKNQ 305
                ...::|.|...|||.:..|          |....|.::.....|...::...:.|:|
Zfish    70 ----PHDLSPISGYPSSLSDTSS----------NKDHSGSESPRSDEDERIQSTKLSDAEK---- 116

  Fly   306 PPRYQCPDCQKSYSTFSGLTKHQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGALKMHIRTHTLPC 370
               :||..|.|||||:|||.||:|.||.|    |.:||||||.|:|.||||||||||||||||||
Zfish   117 ---FQCGLCNKSYSTYSGLMKHKQLHCDA----QSRKSFSCKYCEKEYVSLGALKMHIRTHTLPC 174

  Fly   371 KCNLCGKAFSRPWLLQGHIRTHTGEKPFSCQHCHRAFADRSNLRAHLQTHSDIKKYSCTSCSKTF 435
            .|.:||||||||||||||||||||||||||.||.||||||||||||||||||:|||.|.:|||||
Zfish   175 VCKMCGKAFSRPWLLQGHIRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCKNCSKTF 239

  Fly   436 SRMSLLTKHSEGGC 449
            ||||||.||.|.||
Zfish   240 SRMSLLHKHEESGC 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	zf-C2H2	309..331	CDD:278523	14/21 (67%)
		C2H2 Zn finger	311..331	CDD:275370	13/19 (68%)
		zf-C2H2	344..366	CDD:278523	18/21 (86%)
		C2H2 Zn finger	346..366	CDD:275368	16/19 (84%)
		zf-C2H2	370..392	CDD:278523	18/21 (86%)
		C2H2 Zn finger	372..392	CDD:275368	17/19 (89%)
		zf-H2C2_2	385..408	CDD:290200	20/22 (91%)
		zf-C2H2	398..420	CDD:278523	19/21 (90%)
		C2H2 Zn finger	400..420	CDD:275368	17/19 (89%)
		C2H2 Zn finger	428..444	CDD:275368	12/15 (80%)
snai2	NP_001008581.1	C2H2 Zn finger	119..139	CDD:275368	13/19 (68%)
		C2H2 Zn finger	150..170	CDD:275368	16/19 (84%)
		C2H2 Zn finger	176..196	CDD:275368	17/19 (89%)
		zf-H2C2_2	189..212	CDD:290200	20/22 (91%)
		C2H2 Zn finger	204..224	CDD:275368	17/19 (89%)
		zf-H2C2_2	216..241	CDD:290200	20/24 (83%)
		C2H2 Zn finger	232..248	CDD:275368	12/15 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11696
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004977
OrthoInspector	1	1.000	-	-		mtm6484
orthoMCL	1	0.900	-	-		OOG6_107394
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3546
SonicParanoid	1	1.000	-	-		X955
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.700