DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment esg and wek

DIOPT Version :9

Sequence 1:NP_476600.1 Gene:esg / 34903 FlyBaseID:FBgn0001981 Length:470 Species:Drosophila melanogaster
Sequence 2:NP_001260472.1 Gene:wek / 48785 FlyBaseID:FBgn0001990 Length:470 Species:Drosophila melanogaster


Alignment Length:454 Identity:95/454 - (20%)
Similarity:150/454 - (33%) Gaps:141/454 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 HSNTPNEPQDLCVKKMEILEENPSEELINVSDCCED--EGVDVDHTDDE-HIEEEDEDVDVDVDS 94
            ||. |.:.|||...::|          ..:...|:.  |.:|:|.|:|. .:.||....|.....
  Fly    84 HSE-PQDSQDLDALRLE----------YGLPPACKQDLEFLDIDDTEDRCSLVEELTISDHSTSP 137

  Fly    95 DPN-QTQAAALAAAAAVAAAAAASVVVPTPTYPKYPWNNFHMSPYTAEFYRTINQQGHQILPLRG 158
            .|: :.|.....|......:....:..||.:.|:               ..|...:..|....|.
  Fly   138 SPDFEAQTVRTRANLKQCNSDPKVLASPTASIPE---------------VETKRSRRQQFAAKRN 187

  Fly   159 DLIAPSSPSDSLGSLSPPPHHYLHGRASSVSPPMRSEIIHRPIGVRQHRFLPYPQMPGYPSLGGY 223
            ..:..::.||.        ...:.....:||||                  |..:..|.|...| 
  Fly   188 SKVYTATESDD--------EEAILDEDEAVSPP------------------PLKRKRGRPKGSG- 225

  Fly   224 THTHHHHAPISPAYSENSYYSMRSMTPESSCSSSLPEDLSLKHKNL--NLNLNTSQPGEQAAAKT 286
                                                     |.||:  :.|:.:.:|.:.|.:|.
  Fly   226 -----------------------------------------KQKNVDDSDNVTSREPDDNAKSKQ 249

  Fly   287 GD------MSP-----------------ET-MPNASAKKDKNQ----PPRYQCPDCQKSYSTFSG 323
            .|      |||                 || |...:.::.|:.    |.:|.|..|.|...||:.
  Fly   250 DDKTSELSMSPHGSQSSNFVDYPCKICNETFMSFMALRRHKHDMHGGPKKYVCDHCGKGLKTFTS 314

  Fly   324 LTKHQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGALKMHIRTHTLP-CKCNLCGKAFSRPWLLQG 387
            |.:||..|..       :|...|..|:..:.:...|::|.:||..| .:||:|||......:|..
  Fly   315 LVEHQLVHTE-------EKPCICPVCNAGFKNKARLRVHSQTHGEPKFECNVCGKKLQTRAILNK 372

  Fly   388 HIRTHTGEKPFSCQHCHRAFADRSNLRAHLQTHSDIKKYSCTSCSKTFS-----RMSLLTKHSE 446
            |...||.|:.|.|:.|.....:.:.|:.||..|:.::.|.|..|.|.|:     |.....||.|
  Fly   373 HKYVHTDERRFKCEVCGSGCKNSTALKIHLLGHTGLRPYVCKYCGKAFASNTNCRSHKWKKHPE 436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
esgNP_476600.1 zf-C2H2 309..331 CDD:278523 9/21 (43%)
C2H2 Zn finger 311..331 CDD:275370 8/19 (42%)
zf-C2H2 344..366 CDD:278523 4/21 (19%)
C2H2 Zn finger 346..366 CDD:275368 4/19 (21%)
zf-C2H2 370..392 CDD:278523 7/21 (33%)
C2H2 Zn finger 372..392 CDD:275368 7/19 (37%)
zf-H2C2_2 385..408 CDD:290200 8/22 (36%)
zf-C2H2 398..420 CDD:278523 6/21 (29%)
C2H2 Zn finger 400..420 CDD:275368 5/19 (26%)
C2H2 Zn finger 428..444 CDD:275368 5/20 (25%)
wekNP_001260472.1 zf-AD 11..80 CDD:214871
C2H2 Zn finger 273..294 CDD:275368 4/20 (20%)
C2H2 Zn finger 302..322 CDD:275368 8/19 (42%)
C2H2 Zn finger 330..350 CDD:275368 4/19 (21%)
C2H2 Zn finger 357..377 CDD:275368 7/19 (37%)
C2H2 Zn finger 385..405 CDD:275368 5/19 (26%)
zf-H2C2_2 397..422 CDD:290200 9/24 (38%)
C2H2 Zn finger 413..429 CDD:275368 5/15 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24377
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
11.100

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