DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment esg and snai1

DIOPT Version :9

Sequence 1:	NP_476600.1	Gene:	esg / 34903	FlyBaseID:	FBgn0001981	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_989267.1	Gene:	snai1 / 394880	XenbaseID:	XB-GENE-479970	Length:	262	Species:	Xenopus tropicalis

Alignment Length:	288	Identity:	137/288 - (47%)
Similarity:	172/288 - (59%)	Gaps:	42/288 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 PHHYLHGRASSVS-PPMRSEIIHRPIGVRQHRFLPYPQMPGYP-----SLGGYTHTHHHHAP--- 232
            |..:|..:..|.| .|..||:..:.:.:....:..|| :|..|     :.|.|      :.|
Frog     2 PRSFLVKKHFSASKKPNYSELESQTVYISPFIYDKYP-LPVIPQPEILTTGAY------YTPLVW 59

  Fly   233 ----ISPAYSENSYYSMRSMTPESSCSSSLPEDLSLKHKNLNLNLNTSQPGEQAAAKTGDMSPET 293
                ::..::....|....::|.||..||.|.||:......:....||.|...|::.|
Frog    60 DTSLLTTFFTSEPDYKKSPISPSSSDDSSKPLDLTSFSSEDDEGGKTSDPPSPASSAT------- 117

  Fly   294 MPNASAKKDKNQPPRYQCPDCQKSYSTFSGLTKHQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGA 358
                       :..::||..|.||||||:||:||:|.||    .:|.:||||||.|:|.||||||
Frog   118 -----------EAEKFQCNQCSKSYSTFAGLSKHKQLHC----DSQARKSFSCKYCEKEYVSLGA 167

  Fly   359 LKMHIRTHTLPCKCNLCGKAFSRPWLLQGHIRTHTGEKPFSCQHCHRAFADRSNLRAHLQTHSDI 423
            ||||||:|||||.|.:||||||||||||||||||||||||||.||:||||||||||||||||||:
Frog   168 LKMHIRSHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCTHCNRAFADRSNLRAHLQTHSDV 232

  Fly   424 KKYSCTSCSKTFSRMSLLTKHSEGGCPG 451
            |||.|.:||:||||||||.||.|.||.|
Frog   233 KKYQCKNCSRTFSRMSLLHKHEETGCTG 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	zf-C2H2	309..331	CDD:278523	14/21 (67%)
		C2H2 Zn finger	311..331	CDD:275370	13/19 (68%)
		zf-C2H2	344..366	CDD:278523	18/21 (86%)
		C2H2 Zn finger	346..366	CDD:275368	16/19 (84%)
		zf-C2H2	370..392	CDD:278523	18/21 (86%)
		C2H2 Zn finger	372..392	CDD:275368	17/19 (89%)
		zf-H2C2_2	385..408	CDD:290200	20/22 (91%)
		zf-C2H2	398..420	CDD:278523	19/21 (90%)
		C2H2 Zn finger	400..420	CDD:275368	17/19 (89%)
		C2H2 Zn finger	428..444	CDD:275368	11/15 (73%)
snai1	NP_989267.1	DUF4764	<97..>156	CDD:318226	26/80 (33%)
		C2H2 Zn finger	124..144	CDD:275370	13/19 (68%)
		C2H2 Zn finger	155..175	CDD:275368	16/19 (84%)
		COG5048	<176..>252	CDD:227381	65/75 (87%)
		C2H2 Zn finger	181..201	CDD:275368	17/19 (89%)
		C2H2 Zn finger	209..229	CDD:275368	17/19 (89%)
		C2H2 Zn finger	237..253	CDD:275368	11/15 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11448
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3084
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004977
OrthoInspector	1	1.000	-	-		mtm9353
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3546
SonicParanoid	1	1.000	-	-		X955
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.990