DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment esg and SNAI3

DIOPT Version :9

Sequence 1:	NP_476600.1	Gene:	esg / 34903	FlyBaseID:	FBgn0001981	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_840101.1	Gene:	SNAI3 / 333929	HGNCID:	18411	Length:	292	Species:	Homo sapiens

Alignment Length:	345	Identity:	142/345 - (41%)
Similarity:	176/345 - (51%)	Gaps:	67/345 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 SVVVPTPTYPKYPWNNFHMSPYTAEFYRTINQQGHQILP-LRGDLIAPSSPSDSLGSLSPPPHHY 180
            |.:|.|.:..:.|  |:.......|.....:..|..::| |..|..|||.|.|     .|.|
Human     4 SFLVKTHSSHRVP--NYRRLETQREINGACSACGGLVVPLLPRDKEAPSVPGD-----LPQP--- 58

  Fly   181 LHGRASSVSPPMRSEIIHRPIGVRQHRFLPYPQMPGY-PSLGGYTHTHHHHAPISPAYSENSYYS 244
             ..|:|:|:                  .:..|.:|.. .:||.               |......
Human    59 -WDRSSAVA------------------CISLPLLPRIEEALGA---------------SGLDALE 89

  Fly   245 MRSMTPESSCSSSLPEDLSLKHKNLNLNL-------NTSQPGEQAAAKTGDMSPETMPNASAKKD 302
            :..:.|.:|.::.:|...||.|.||...|       .|..|....|.:. .:..|.||.|
Human    90 VSEVDPRASRAAIVPLKDSLNHLNLPPLLVLPTRWSPTLGPDRHGAPEK-LLGAERMPRA----- 148

  Fly   303 KNQPPRYQCPDCQKSYSTFSGLTKHQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGALKMHIRTHT 367
               |..::|..|.|.|.|.:||.:|:|.||..    ||.:.|:||.|||.|.|||||||||||||
Human   149 ---PGGFECFHCHKPYHTLAGLARHRQLHCHL----QVGRVFTCKYCDKEYTSLGALKMHIRTHT 206

  Fly   368 LPCKCNLCGKAFSRPWLLQGHIRTHTGEKPFSCQHCHRAFADRSNLRAHLQTHSDIKKYSCTSCS 432
            |||.|.:||||||||||||||:||||||||::|.||.||||||||||||||||||.|||.|..|:
Human   207 LPCTCKICGKAFSRPWLLQGHVRTHTGEKPYACSHCSRAFADRSNLRAHLQTHSDAKKYRCRRCT 271

  Fly   433 KTFSRMSLLTKHSEGG-CPG 451
            |||||||||.:|.|.| |||
Human   272 KTFSRMSLLARHEESGCCPG 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	zf-C2H2	309..331	CDD:278523	9/21 (43%)
		C2H2 Zn finger	311..331	CDD:275370	9/19 (47%)
		zf-C2H2	344..366	CDD:278523	17/21 (81%)
		C2H2 Zn finger	346..366	CDD:275368	16/19 (84%)
		zf-C2H2	370..392	CDD:278523	17/21 (81%)
		C2H2 Zn finger	372..392	CDD:275368	16/19 (84%)
		zf-H2C2_2	385..408	CDD:290200	17/22 (77%)
		zf-C2H2	398..420	CDD:278523	17/21 (81%)
		C2H2 Zn finger	400..420	CDD:275368	17/19 (89%)
		C2H2 Zn finger	428..444	CDD:275368	11/15 (73%)
SNAI3	NP_840101.1	SNAG domain. /evidence=ECO:0000250	1..20		5/17 (29%)
		C2H2 Zn finger	154..174	CDD:275370	9/19 (47%)
		C2H2 Zn finger	185..205	CDD:275368	16/19 (84%)
		COG5048	<206..>278	CDD:227381	58/71 (82%)
		C2H2 Zn finger	211..231	CDD:275368	16/19 (84%)
		C2H2 Zn finger	239..259	CDD:275368	17/19 (89%)
		C2H2 Zn finger	267..283	CDD:275368	11/15 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11668
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8461
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X955
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.770