DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esg and scrt2

DIOPT Version :9

Sequence 1:	NP_476600.1	Gene:	esg / 34903	FlyBaseID:	FBgn0001981	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_998802.1	Gene:	scrt2 / 325372	ZFINID:	ZDB-GENE-030131-4097	Length:	312	Species:	Danio rerio

Alignment Length:	297	Identity:	110/297 - (37%)
Similarity:	145/297 - (48%)	Gaps:	65/297 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 HTHHHHAPISPAYSENSYYSMRSMTPESSCSSSLPEDL-----SLKHKNLNLNLNTS-------- 276
            |.||||   :..:.::|:...||......|.:...:|.     ..:.|..::.||:.
Zfish    23 HHHHHH---NDRHMDDSFSRSRSSLGVRLCENGYIKDYISSSEYTEEKQADMKLNSELLYSPVSS 84

  Fly   277 ------QPG-------EQAAAKTGDMSPE--------TMP---------------NASAKKDK-- 303
                  ||.       :......|..|.|        ||.               :.:||.|:
Zfish    85 GGGEYCQPDLEHPDSPQSGLTARGYFSSESESLSEGYTMDAFFISDGRSRRKGEVSEAAKADEVE 149

  Fly   304 -------NQPPRYQCPDCQKSYSTFSGLTKHQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGALKM 361
                   |...|:.|.:|.|:|:|.|.|::|:|.| .:.:....:|   |..|||.|||:.||.|
Zfish   150 KEVVGVNNGGARHTCNECGKTYATSSNLSRHKQTH-RSLDSKMARK---CPTCDKVYVSMPALAM 210

  Fly   362 HIRTHTLPCKCNLCGKAFSRPWLLQGHIRTHTGEKPFSCQHCHRAFADRSNLRAHLQTHSDIKKY 426
            ||.||.|..||::|.||||||||||||:|:|||||||:|.||.:|||||||||||:||||..|.|
Zfish   211 HILTHDLKHKCHVCSKAFSRPWLLQGHMRSHTGEKPFACAHCGKAFADRSNLRAHMQTHSAFKHY 275

  Fly   427 SCTSCSKTFSRMSLLTKHSEGGCPGGSAGSSSSSELN 463
            ||..|:|||:..|.|.||.|..|..||.....|...|
Zfish   276 SCKRCNKTFALKSYLNKHYESACFRGSGDEDESGSEN 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	zf-C2H2	309..331	CDD:278523	9/21 (43%)
		C2H2 Zn finger	311..331	CDD:275370	9/19 (47%)
		zf-C2H2	344..366	CDD:278523	12/21 (57%)
		C2H2 Zn finger	346..366	CDD:275368	12/19 (63%)
		zf-C2H2	370..392	CDD:278523	16/21 (76%)
		C2H2 Zn finger	372..392	CDD:275368	15/19 (79%)
		zf-H2C2_2	385..408	CDD:290200	16/22 (73%)
		zf-C2H2	398..420	CDD:278523	16/21 (76%)
		C2H2 Zn finger	400..420	CDD:275368	15/19 (79%)
		C2H2 Zn finger	428..444	CDD:275368	7/15 (47%)
scrt2	NP_998802.1	zf-C2H2	162..184	CDD:278523	9/21 (43%)
		C2H2 Zn finger	164..184	CDD:275368	9/19 (47%)
		C2H2 Zn finger	195..212	CDD:275371	10/16 (63%)
		COG5048	219..>295	CDD:227381	53/75 (71%)
		zf-C2H2	219..241	CDD:278523	16/21 (76%)
		C2H2 Zn finger	221..241	CDD:275368	15/19 (79%)
		zf-H2C2_2	234..257	CDD:290200	16/22 (73%)
		zf-C2H2	247..269	CDD:278523	16/21 (76%)
		C2H2 Zn finger	249..269	CDD:275368	15/19 (79%)
		C2H2 Zn finger	277..293	CDD:275368	7/15 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810