DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment esg and ZNF683

DIOPT Version :9

Sequence 1:	NP_476600.1	Gene:	esg / 34903	FlyBaseID:	FBgn0001981	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	XP_006710618.1	Gene:	ZNF683 / 257101	HGNCID:	28495	Length:	533	Species:	Homo sapiens

Alignment Length:	352	Identity:	91/352 - (25%)
Similarity:	130/352 - (36%)	Gaps:	75/352 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 YTAEFYRTINQQGHQILPLRGDLIAPSSPSDSLGSLSPPPHHYLHGRAS------SVSPPMRSEI 196
            :|.::.:..::.|.|  |.|....||.....|..|.||||   |..|.|      ...||:.|
Human   132 FTVKYPQNKDKLGKQ--PERAGEGAPCPAFSSHNSSSPPP---LQNRKSPSPLAFCPCPPVNS-- 189

  Fly   197 IHRPIGVRQHRFLPYPQMPGYPSLGGYTHTHHHHA------------PISPAYSENSYYSMRSMT 249
            |.:.:....|.|     .||||.|....|...:.|            |..|:|...:..|:..|.
Human   190 ISKELPFLLHAF-----YPGYPLLLPPPHLFTYGALPSDQCPHLLMLPQDPSYPTMAMPSLLMMV 249

  Fly   250 -----PESSCSSSLPEDLSLKHKNLNLNLNTSQPGEQAAAKTGDMSPETMPNASAKKDKNQPPRY 309
                 |.:...:.||...:.:.....|......||..||...   ||.......|...|..|...
Human   250 NELGHPSARWETLLPYPGAFQASGQALPSQARNPGAGAAPTD---SPGLERGGMASPAKRVPLSS 311

  Fly   310 QCPDCQKSYSTFSGLTKHQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGALKMHIRTHT--LPCKC 372
            |.......|              |..:.|. |..:.|..|.|::..|..||:|:|.|:  .|.:|
Human   312 QTGTAALPY--------------PLKKKNG-KILYECNICGKSFGQLSNLKVHLRVHSGERPFQC 361

  Fly   373 NLCGKAFSRPWLLQGHIRTHTGEKPFSC--------------------QHCHRAFADRSNLRAHL 417
            .||.|:|::...||.|...||||:|..|                    :.||:.|:..|||:.||
Human   362 ALCQKSFTQLAHLQKHHLVHTGERPHKCSIPWVPGRNHWKSFQAWREREVCHKRFSSSSNLKTHL 426

  Fly   418 QTHSDIKKYSCTSCSKTFSRMSLLTKH 444
            :.||..:.:.|:.|...|::...|..|
Human   427 RLHSGARPFQCSVCRSRFTQHIHLKLH 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	zf-C2H2	309..331	CDD:278523	2/21 (10%)
		C2H2 Zn finger	311..331	CDD:275370	1/19 (5%)
		zf-C2H2	344..366	CDD:278523	8/21 (38%)
		C2H2 Zn finger	346..366	CDD:275368	8/19 (42%)
		zf-C2H2	370..392	CDD:278523	8/21 (38%)
		C2H2 Zn finger	372..392	CDD:275368	8/19 (42%)
		zf-H2C2_2	385..408	CDD:290200	11/42 (26%)
		zf-C2H2	398..420	CDD:278523	9/41 (22%)
		C2H2 Zn finger	400..420	CDD:275368	9/39 (23%)
		C2H2 Zn finger	428..444	CDD:275368	4/15 (27%)
ZNF683	XP_006710618.1	COG5048	<326..>448	CDD:227381	39/122 (32%)
		zf-C2H2	331..353	CDD:278523	8/21 (38%)
		C2H2 Zn finger	333..353	CDD:275368	8/19 (42%)
		zf-H2C2_2	345..370	CDD:290200	11/24 (46%)
		C2H2 Zn finger	361..381	CDD:275368	8/19 (42%)
		C2H2 Zn finger	389..429	CDD:275368	9/39 (23%)
		zf-H2C2_2	421..446	CDD:290200	9/24 (38%)
		C2H2 Zn finger	437..457	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910