Protein Alignment esg and ZNF281

DIOPT Version :10

• Sequence 1: NP_476600.1
• Gene: esg / 34903
• FlyBaseID: FBgn0287768
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_036614.1
• Gene: ZNF281 / 23528
• HGNCID: 13075
• Length: 895
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 89/400 - (22%)
• Similarity: 140/400 - (35%)
• Gaps: 115/400 - (28%)

  Fly   123 PTYPKYPWNNFHMSPYTAEFYRTINQQGHQILPLRGDLIAPSSPSDSLGSLSPPPHHYLHGRASS 187
            ||:|:......|..|....|.|                     |:   ||.:|||...|....|:
Human    44 PTFPQGMVMFNHRLPPVTSFTR---------------------PA---GSAAPPPQCVLSSSTSA 84

  Fly   188 V-----SPPMRSEIIHRP----------------------IGVRQHRFLPYPQMPGYPSLGGYTH 225
            .     .||...::..:.                      :.::|.:       |..|......|
Human    85 APAAEPPPPPAPDMTFKKEPAASAAAFPSQRTSWGFLQSLVSIKQEK-------PADPEEQQSHH 142

  Fly   226 THHHHAPISPAYSENSYYSMRSMTPESS--------CSSSLPEDLSLKHKNLNLNLNTSQPGE-- 280
            .||||          .|..:.:...|.|        .|..:.:|||:.|:::.     .||.:
Human   143 HHHHH----------HYGGLFAGAEERSPGLGGGEGGSHGVIQDLSILHQHVQ-----QQPAQHH 192

  Fly   281 -----QAAAKTGDM--SPETMPNASAKKDKNQPPRYQCPDCQKSYSTFSGLTKHQQFHCPAAEG- 337
                 .::::|.|.  :.|...:.:.||.|...|..|....::..|..|.         |:..|
Human   193 RDVLLSSSSRTDDHHGTEEPKQDTNVKKAKRPKPESQGIKAKRKPSASSK---------PSLVGD 248

  Fly   338 ------NQVKKSFSCKDCDKTYVSLGALKMHIRTHT--LPCKCNLCGKAFSRPWLLQGHIRTHTG 394
                  :..:|...|..|...:.|...|:.|:..||  .|.:|:.|...|.:.:|||.|.:.|:.
Human   249 GEGAILSPSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSR 313

  Fly   395 EKPFSCQHCHRAFADRSNLRAHLQTHSDIKKYSCTSCSKTFSRMSLLTKHSE-------GGCPGG 452
            ||||.|..|...|..:.::..|.:|||..|.|.|.:|.:.|||...|.||..       .|....
Human   314 EKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEVIVKGATSA 378

  Fly   453 SAGSSSSSEL 462
            ..|||:.:.:
Human   379 EPGSSNHTNM 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	KREPA	<278..>329	CDD:483960	11/59 (19%)
		zf-C2H2	309..331	CDD:395048	3/21 (14%)
		C2H2 Zn finger	311..331	CDD:275370	2/19 (11%)
		zf-C2H2	344..366	CDD:395048	5/21 (24%)
		C2H2 Zn finger	346..366	CDD:275368	5/19 (26%)
		zf-C2H2	370..392	CDD:395048	7/21 (33%)
		C2H2 Zn finger	372..392	CDD:275368	7/19 (37%)
		zf-H2C2_2	385..408	CDD:463886	10/22 (45%)
		zf-C2H2	398..420	CDD:395048	5/21 (24%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	428..444	CDD:275368	6/15 (40%)
ZNF281	NP_036614.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		89/399 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..113		12/73 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..149		7/35 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..253		14/83 (17%)
		zf-C2H2_4	261..283	CDD:464025	5/21 (24%)
		C2H2 Zn finger	263..283	CDD:275368	5/19 (26%)
		zf-H2C2_2	275..300	CDD:463886	8/24 (33%)
		C2H2 Zn finger	291..311	CDD:275368	7/19 (37%)
		C2H2 Zn finger	319..339	CDD:275368	4/19 (21%)
		zf-H2C2_2	331..356	CDD:463886	9/24 (38%)
		C2H2 Zn finger	347..366	CDD:275368	8/18 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..427		3/11 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	638..660
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	778..817