DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment esg and klf-1

DIOPT Version :9

Sequence 1:	NP_476600.1	Gene:	esg / 34903	FlyBaseID:	FBgn0001981	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_497632.1	Gene:	klf-1 / 175404	WormBaseID:	WBGene00018990	Length:	497	Species:	Caenorhabditis elegans

Alignment Length:	407	Identity:	89/407 - (21%)
Similarity:	153/407 - (37%)	Gaps:	92/407 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 AAAVAAAAAASVVVPTPTYPKY-PWNNFHMSPYTAEFYRT--INQQGHQILPLRGDLIAP----- 163
            :.|..:::::||......:..: |:.|.|.....:.|..|  .|.:..||   :.|.||.
Worm   109 SGAATSSSSSSVFERQSDFSAFAPYKNSHFDSTQSLFQPTTSFNDRLEQI---KSDFIAEHQKSM 170

  Fly   164 ------SSPSDSLGSLSPPPHHYLHGRASSVSPPMRSEII--HRPIG-----------VRQHRFL 209
                  ::|:.:||:    ....:..:.|:.:|.:..|.:  .||.|           :.|.|.|
Worm   171 SSFSGFNTPTTALGA----AFQGMQVKKSAFAPVLLRENLDTRRPGGHLISDILNRDPLPQSRNL 231

  Fly   210 PYPQMPGYP---------------SLGGYTHTHHH---------HAPISPAYSENSY-YSMR--- 246
            ........|               |.|...|..|.         .:|.||....::. :.:|
Worm   232 NLNMARNVPIRLIHSTSNFDIASSSSGDSGHQDHESIVVEDADMDSPTSPCVKRSAMNFDLRDEP 296

  Fly   247 -SMTPES-SCSSSLPEDLSLKHKNLN----LNLNTSQPGEQAAAKTGDMSPETMPNASAKKDKNQ 305
             ::..|| |.:|.||..:|   .::|    .|.:..:...:....|.......||:|:.:.|. .
Worm   297 LTVNVESVSSTSDLPSSVS---SSVNSFVYQNFDPLEFKRKIDELTASACLAVMPDANGQVDP-M 357

  Fly   306 PPRYQCPDCQKSYSTFSGLTKHQQFHCPAAEGNQVKKSFSCKDCDKTYVSL------GALKMHIR 364
            ..:.|....:|.      :.:||.....|::...|..|....:|:.:..|.      ...::|..
Worm   358 AIKTQLDAIKKQ------MEEHQTHMAEASQRLHVDSSLEDSNCEPSPSSSYDASEPSVKRLHHC 416

  Fly   365 THTLPCKCNLCGKAFSRPWLLQGHIRTHTGEKPFSC--QHCHRAFADRSNLRAHLQTHSDIKKYS 427
            ||.      .|||.:::...|:.|.||||||||:.|  ..|...||....|..|.:.|:..:.:.
Worm   417 THP------NCGKVYTKSSHLKAHFRTHTGEKPYECSWDGCDWRFARSDELTRHYRKHTGDRPFK 475

  Fly   428 CTSCSKTFSRMSLLTKH 444
            |:.||:.|||...|:.|
Worm   476 CSQCSRAFSRSDHLSLH 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	zf-C2H2	309..331	CDD:278523	4/21 (19%)
		C2H2 Zn finger	311..331	CDD:275370	3/19 (16%)
		zf-C2H2	344..366	CDD:278523	3/27 (11%)
		C2H2 Zn finger	346..366	CDD:275368	3/25 (12%)
		zf-C2H2	370..392	CDD:278523	6/21 (29%)
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		zf-H2C2_2	385..408	CDD:290200	12/24 (50%)
		zf-C2H2	398..420	CDD:278523	6/23 (26%)
		C2H2 Zn finger	400..420	CDD:275368	6/21 (29%)
		C2H2 Zn finger	428..444	CDD:275368	7/15 (47%)
klf-1	NP_497632.1	COG5048	398..>481	CDD:227381	26/88 (30%)
		C2H2 Zn finger	419..438	CDD:275368	6/24 (25%)
		zf-H2C2_2	430..457	CDD:290200	13/26 (50%)
		C2H2 Zn finger	446..468	CDD:275368	6/21 (29%)
		zf-H2C2_2	460..485	CDD:290200	7/24 (29%)
		C2H2 Zn finger	476..496	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000