DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment esg and Snai1

DIOPT Version :9

Sequence 1:	NP_476600.1	Gene:	esg / 34903	FlyBaseID:	FBgn0001981	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_446257.1	Gene:	Snai1 / 116490	RGDID:	620758	Length:	264	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	127/340 - (37%)
Similarity:	164/340 - (48%)	Gaps:	85/340 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 SVVVPTPTYPKYPWNNFHMSPYTAEFYRTINQQGHQILPLRGDLIAPSSPSDSLGSLSPPPHHYL 181
            |.:|..|:.|:...|...:.....||  |..|              |...:..|.::.||
  Rat     4 SFLVRKPSDPRRKPNYSELQDACVEF--TFQQ--------------PYDQAHLLAAIPPP----- 47

  Fly   182 HGRASSVSPPMRSEIIHRPIGVRQHRFLPYPQMPGYPSLGGYTHTHHHHAPI--SPAYSENSYYS 244
                 .|..|..|    .|..:.....:|..|...:.:|           |:  ||..:|
  Rat    48 -----EVLNPAAS----LPTLIWDSLLVPQVQPVAWATL-----------PLRESPRAAE----- 87

  Fly   245 MRSMTPESSCSSSLPEDLSLKHKNLNLNLNTSQPGEQAAAKTGDMSPETMPNASAKKDKNQPPRY 309
            :.|::.|.|..||.|.             :...|...:.:.|...|.|.
  Rat    88 LTSLSDEDSGKSSQPP-------------SPPSPAPSSFSSTSASSLEA---------------- 123

  Fly   310 QCPDCQKSYSTFSGLTK--HQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGALKMHIRTHTLPCKC 372
                  :::..|.||.:  .|......|:..|.:|:|:||.|:|.|:||||||||||:|||||.|
  Rat   124 ------EAFIAFPGLGQLPKQLARLSVAKDPQSRKAFNCKYCNKEYLSLGALKMHIRSHTLPCVC 182

  Fly   373 NLCGKAFSRPWLLQGHIRTHTGEKPFSCQHCHRAFADRSNLRAHLQTHSDIKKYSCTSCSKTFSR 437
            ..||||||||||||||:|||||||||||.||:||||||||||||||||||:|:|.|.:|::||||
  Rat   183 TTCGKAFSRPWLLQGHVRTHTGEKPFSCSHCNRAFADRSNLRAHLQTHSDVKRYQCQACARTFSR 247

  Fly   438 MSLLTKHSEGGCPGG 452
            ||||.||.|.||.||
  Rat   248 MSLLHKHQESGCSGG 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
esg	NP_476600.1	zf-C2H2	309..331	CDD:278523	4/23 (17%)
		C2H2 Zn finger	311..331	CDD:275370	4/21 (19%)
		zf-C2H2	344..366	CDD:278523	16/21 (76%)
		C2H2 Zn finger	346..366	CDD:275368	15/19 (79%)
		zf-C2H2	370..392	CDD:278523	17/21 (81%)
		C2H2 Zn finger	372..392	CDD:275368	16/19 (84%)
		zf-H2C2_2	385..408	CDD:290200	19/22 (86%)
		zf-C2H2	398..420	CDD:278523	19/21 (90%)
		C2H2 Zn finger	400..420	CDD:275368	17/19 (89%)
		C2H2 Zn finger	428..444	CDD:275368	10/15 (67%)
Snai1	NP_446257.1	C2H2 Zn finger	156..176	CDD:275368	15/19 (79%)
		COG5048	<177..>253	CDD:227381	62/75 (83%)
		zf-C2H2	180..202	CDD:278523	17/21 (81%)
		C2H2 Zn finger	182..202	CDD:275368	16/19 (84%)
		zf-H2C2_2	195..218	CDD:290200	19/22 (86%)
		zf-C2H2	208..230	CDD:278523	19/21 (90%)
		C2H2 Zn finger	210..230	CDD:275368	17/19 (89%)
		C2H2 Zn finger	238..255	CDD:275368	11/16 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X955
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.770