DRSC/TRiP Functional Genomics Resources

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Protein Alignment HCN1 and NAS6

DIOPT Version :10

Sequence 1:NP_066550.2 Gene:HCN1 / 348980 HGNCID:4845 Length:890 Species:Homo sapiens
Sequence 2:NP_011748.3 Gene:NAS6 / 853147 SGDID:S000003464 Length:228 Species:Saccharomyces cerevisiae


Alignment Length:269 Identity:50/269 - (18%)
Similarity:87/269 - (32%) Gaps:96/269 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   310 HWDGCLQ------FLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVS 368
            ||....|      ||:..:::      |:|::..:||....:         |:.|.....:...|
Yeast    41 HWSVSFQAHEITSFLLSKMEN------VNLDDYPDDSGWTPF---------HIACSVGNLEVVKS 90

Human   369 MSDLWITM-LSMIV--GATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQK 430
            :.|..:.. |:.|.  |.||..:.||                 :|:.:|.|::..:.....::.|
Yeast    91 LYDRPLKPDLNKITNQGVTCLHLAVG-----------------KKWFEVSQFLIENGASVRIKDK 138

Human   431 IHDYYEHRYQ--GKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRF 493
            .:....||..  |.:     .|.||...|.:..||:..::  ...|||                 
Yeast   139 FNQIPLHRAASVGSL-----KLIELLCGLGKSAVNWQDKQ--GWTPLF----------------- 179

Human   494 EVFQPGDYIIREGAVGKKMYFIQHGVAGV--ITKSSKEMKLTDGSYFGEICLLTKGRRTASVRAD 556
                   :.:.||          ||.|.|  :.|...|..|.|          .||.:...|..:
Yeast   180 -------HALAEG----------HGDAAVLLVEKYGAEYDLVD----------NKGAKAEDVALN 217

Human   557 TYCRLYSLS 565
            ...:.:.|:
Yeast   218 EQVKKFFLN 226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HCN1NP_066550.2 Disordered. /evidence=ECO:0000305|PubMed:28086084 1..93
Ion_trans_N 98..140 CDD:400630
PLN03192 133..>620 CDD:215625 50/269 (19%)
Selectivity filter. /evidence=ECO:0000305|PubMed:28086084 358..362 1/3 (33%)
CAP_ED 475..583 CDD:237999 16/93 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 644..692
PRK10263 <662..>842 CDD:236669
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 725..796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 845..890
NAS6NP_011748.3 ANK repeat 1..33 CDD:293786
ANKYR 3..226 CDD:440430 49/267 (18%)
ANK repeat 35..69 CDD:293786 7/33 (21%)
ANK repeat 71..104 CDD:293786 6/41 (15%)
ANK repeat 107..137 CDD:293786 8/46 (17%)
ANK repeat 139..171 CDD:293786 9/36 (25%)
ANK repeat 173..205 CDD:293786 12/67 (18%)
Blue background indicates that the domain is not in the aligned region.

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