Protein Alignment HCN1 and Hcn1

DIOPT Version :10

• Sequence 1: NP_066550.2
• Gene: HCN1 / 348980
• HGNCID: 4845
• Length: 890
• Species: Homo sapiens
• Sequence 2: NP_445827.2
• Gene: Hcn1 / 84390
• RGDID: 620688
• Length: 902
• Species: Rattus norvegicus
• Alignment Length: 914
• Identity: 849/914 - (92%)
• Similarity: 859/914 - (93%)
• Gaps: 36/914 - (3%)

Human     1 MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGG 65
            |||||||||:||||||||||:|:||.||  |||||:||||||||||.|| ||||||||||||
  Rat     1 MEGGGKPNSASNSRDDGNSVYPSKAPAT--GPAAADKRLGTPPGGGAAG-KEHGNSVCFKVD--- 59

Human    66 GGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTA 130
                 |||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    60 -----GGGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTA 119

Human   131 GFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFR 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   120 GFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFR 184

Human   196 TGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFT 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   185 TGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFT 249

Human   261 KILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDF 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   250 KILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDF 314

Human   326 PPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFV 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   315 PPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFV 379

Human   391 GHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELND 455
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
  Rat   380 GHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELND 444

Human   456 PLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVA 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   445 PLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVA 509

Human   521 GVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFET 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   510 GVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFET 574

Human   586 VAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNST 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||.||.|
  Rat   575 VAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIPPINYPQMTALNCT 639

Human   651 SSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAAR 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||.|
  Rat   640 SSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPIQSPLATR 704

Human   716 TFHYASPTASQLSLMQQ-QP---QQQVQQSQP-PQTQPQQP-------------------SPQPQ 756
            ||||||||||||||||| ||   |.||||:|| ||.|||||                   ..|||
  Rat   705 TFHYASPTASQLSLMQQPQPQLQQSQVQQTQPQPQPQPQQPQQQQQQQQQQQQQQQQQQQQQQPQ 769

Human   757 TPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTA 821
            |||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||:..
  Rat   770 TPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTMISRPHPTVGESLASIPQPMAT 834

Human   822 VPGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRF 886
            |..||||||.|||||||||||||||||||||||||||||||| ||:.|||.||||.|||||||||
  Rat   835 VHSTGLQAGSRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPP-AAVQRESPSVLNKDPDAEKPRF 898

Human   887 ASNL 890
            ||||
  Rat   899 ASNL 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HCN1	NP_066550.2	Disordered. /evidence=ECO:0000305|PubMed:28086084	1..93		73/91 (80%)
		Ion_trans_N	98..140	CDD:400630	41/41 (100%)
		PLN03192	133..>620	CDD:215625	485/486 (100%)
		Selectivity filter. /evidence=ECO:0000305|PubMed:28086084	358..362		3/3 (100%)
		CAP_ED	475..583	CDD:237999	107/107 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	644..692		45/47 (96%)
		PRK10263	<662..>842	CDD:236669	165/203 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	725..796		65/94 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..890		39/44 (89%)
Hcn1	NP_445827.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		66/84 (79%)
		Ion_trans_N	87..129	CDD:400630	41/41 (100%)
		PLN03192	122..>609	CDD:215625	485/486 (100%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:O60741	347..351		3/3 (100%)
		CAP_ED	464..572	CDD:237999	107/107 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	634..681		44/46 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	713..824		80/110 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	858..902		39/44 (89%)