Protein Alignment HCN1 and Hcn1

DIOPT Version :10

• Sequence 1: NP_066550.2
• Gene: HCN1 / 348980
• HGNCID: 4845
• Length: 890
• Species: Homo sapiens
• Sequence 2: NP_034538.2
• Gene: Hcn1 / 15165
• MGIID: 1096392
• Length: 910
• Species: Mus musculus
• Alignment Length: 922
• Identity: 847/922 - (91%)
• Similarity: 854/922 - (92%)
• Gaps: 44/922 - (4%)

Human     1 MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGG 65
            |||||||||:||||||||||||:||.||  ||.||:||||||||||.|| ||||||||||||
Mouse     1 MEGGGKPNSASNSRDDGNSVFPSKAPAT--GPVAADKRLGTPPGGGAAG-KEHGNSVCFKVD--- 59

Human    66 GGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTA 130
                 |||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    60 -----GGGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTA 119

Human   131 GFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFR 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   120 GFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFR 184

Human   196 TGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFT 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   185 TGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFT 249

Human   261 KILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDF 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   250 KILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDF 314

Human   326 PPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFV 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   315 PPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFV 379

Human   391 GHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELND 455
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
Mouse   380 GHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELND 444

Human   456 PLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVA 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   445 PLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVA 509

Human   521 GVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFET 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   510 GVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFET 574

Human   586 VAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNST 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||.||.|
Mouse   575 VAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIPPINYPQMTALNCT 639

Human   651 SSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAAR 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||.|
Mouse   640 SSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPIQSPLATR 704

Human   716 TFHYASPTASQLSLM--------------------------------QQQPQQQVQQSQPPQTQP 748
            |||||||||||||||                                |||.|||.||.|..|.|.
Mouse   705 TFHYASPTASQLSLMQQPQQQLPQSQVQQTQTQTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 769

Human   749 QQPSPQPQTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRPHPTVGESLA 813
            ||...|||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||
Mouse   770 QQQQQQPQTPGSSTPKNEVHKSTQALHNTNLTKEVRPLSASQPSLPHEVSTLISRPHPTVGESLA 834

Human   814 SIPQPVTAVPGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTD 878
            ||||||.||..||||||.|||||||||||||||||||||||||||||||| ||:.|||.||||||
Mouse   835 SIPQPVAAVHSTGLQAGSRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPP-AAVQRESPSVLNTD 898

Human   879 PDAEKPRFASNL 890
            ||||||||||||
Mouse   899 PDAEKPRFASNL 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HCN1	NP_066550.2	Disordered. /evidence=ECO:0000305|PubMed:28086084	1..93		73/91 (80%)
		Ion_trans_N	98..140	CDD:400630	41/41 (100%)
		PLN03192	133..>620	CDD:215625	485/486 (100%)
		Selectivity filter. /evidence=ECO:0000305|PubMed:28086084	358..362		3/3 (100%)
		CAP_ED	475..583	CDD:237999	107/107 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	644..692		45/47 (96%)
		PRK10263	<662..>842	CDD:236669	162/211 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	725..796		59/102 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	845..890		40/44 (91%)
Hcn1	NP_034538.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		66/84 (79%)
		Ion_trans_N	87..129	CDD:400630	41/41 (100%)
		PLN03192	122..>609	CDD:215625	485/486 (100%)
		Selectivity filter. /evidence=ECO:0000305|PubMed:12089064	347..351		3/3 (100%)
		CAP_ED	464..572	CDD:237999	107/107 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	634..681		44/46 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	771..791		16/19 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..910		41/45 (91%)